Neurogynaecology and Women’s Reproductive Health: A PRISMA Based Systematic Review of Neuroendocrine Regulation, Autonomic Dysfunction, Psychosomatic Stress, and Integrative Therapeutic Outcomes

Harshu Sharma, Lovlish Gupta
In: Research Square · 2026 · doi:10.21203/rs.3.rs-9181695/v1 · W7140219620
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This systematic review identified four neuro-gynaecological pathogenic domains—HPA–HPO axis dysregulation, autonomic nervous system imbalance, psychosomatic stress, and neuro-immune crosstalk—driving women's reproductive disorders.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This PRISMA-guided systematic review examined neuro-gynaecological mechanisms linking the nervous system to female reproductive health, drawing on peer-reviewed clinical, observational, experimental, neuroimaging, and psychosomatic studies (primarily 2000–2026) across multiple gynaecological conditions such as PCOS, dysmenorrhea, chronic pelvic pain, and endometriosis. Across 89 included studies, the authors identify four pathogenic domains: HPA–HPO axis dysregulation related to stress-induced reproductive suppression, autonomic imbalance characterized by sympathetic hyperactivity and reduced vagal tone measured by heart rate variability, psychosomatic stress promoting central sensitisation and disproportionate pain perception, and neuro-immune crosstalk sustaining neurogenic inflammation in chronic pelvic conditions. A stated caveat is that the review is broad in scope across differing study types and focuses on consolidating evidence rather than establishing causal efficacy of specific interventions. This paper is centrally about endometriosis — it frames endometriosis within a biopsychoneuroimmune, neuroendocrine/autonomic/psychosomatic and neuro-immune crosstalk model alongside other chronic pelvic pain conditions.

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