Expression and significance of HGF,c-Met,MVD in ectopic and eutopic endometrium with adenomyosis

Objective:To investigate the expression of HGF and c-Met in ectopic,eutopic endometrium with adenomyosis and normal endometrium and the function of HGF,c-Met in the angiogenesis of adenomyosis,and discuss the relationship of HGF/c-Met and adenomyosis for the possible mechanism.Methods: Immunohistochemical(streptavidin-peroxidase) staining was employed to detect the expression of HGF,c-Met and MVD in 30 cases with adenomyosis(20 in proliferative phase and 10 in secretory phase) proved histologically of ectopic and eutopic tissues and 20 cases(10 in proliferative and secretory phase)of normal endometrial tissues.Results: HGF and c-Met were positive in ectopic,eutopic and control groups.The positive expression rate and expression intensity of HGF and c-Met were both higher in ectopic and eutopic groups compared with control group(P0.05),but expression in secretory phase was higher than that in proliferative phase in all groups.MVD showed the highest expression in ectopic group but moderately higher in eutopic group than control group.Expression of MVD increased with the rise of expression intensity of HGF and c-Met.HGF,c-Met and MVD in ectopic and eutopic groups were correlated.In control group,expression of HGF and c-Met,HGF and MVD were correlated(P0.05),but no correlation was found in the expression of c-Met and MVD.Conclusion: HGF and c-Met function may be involved in the development of adenomyosis by hastening angiogenesis.