The importance of vitamin D in the diagnosis and treatment of adenomyosis

There is still no unified theory of the occurrence of adenomyosis. The theories of retrograde menstruation, metaplasia, activation of Mullerian residues, lymphatic and vascular dissemination, iatrogenic dissemination, immunological changes, genetic predisposition, etc. are discussed. The theory of retrograde menstruation is the most relevant among all these theories. The aim is to study the content of folic acid, vitamins B1, D, E, ferritin in the blood, zinc, copper, calcium in the blood and removed uterine tissues, to assess the hormonal status in women with combined uterine pathology leiomyoma and adenomyosis. 150 women underwent a health examination, residents of the cities of Pavlodar and Nur-Sultan, aged 18 to 49 years with benign dishormonal diseases of reproductive organs (the main group). The control group consisted of 40 women without gynaecological pathology. The study of the somatic status, objective general somatic, clinical and laboratory, gynaecological examination was carried out by routine methods. Ultrasound examination was performed for mammary glands, thyroid gland, pelvic organs in a real-time mode according to standard methods. Similar content being viewed by others Data availability Enquiries about data availability should be directed to the authors. Change history 13 April 2024 This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1007/s11010-024-05007-y

Zhigalenko AR, Karakhalis LY, Papova NS (2017) Clinical and diagnostic parallels in adenomyosis-associated infertility. Kuban Sci Med Bull 24(4):65–73. https://doi.org/10.25207/1608-6228-2017-24-4-65-73 Bergeron C, Amant F, Ferenczy A (2006) Pathology and physiopathology of adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:511–521. https://doi.org/10.1016/j.bpobgyn.2006.01.016 Exacoustos C, Brienza L, Digiovanni A (2011) Adenomyosis three-dimensional sonographic findings of the junctional zone and correlation with histology. Ultras Obstet Gynaecol 37(4):471–479. https://doi.org/10.1002/uog.8900 Graziano A, Lo Monte G, Piva I (2015) Diagnostic findings in adenomyosis a pictorial review on the major concerns. Eur Rev Med Pharm Sci 19(7):1146–1154 Kunz G, Herbertz M, Beil D, Huppert P, Leyendecker G (2007) Adenomyosis as a disorder of the early and late human reproductive period. Reprod BioMed Online 15:681–685. https://doi.org/10.1016/s1472-6483(10)60535-4 Luciano DE, Exacoustos C, Albrecht L (2013) Three-dimensional ultrasound in diagnosis of adenomyosis: histologic correlation with ultrasound targeted biopsies of the uterus. J Minim Invasive Gynecol 20:803–810. https://doi.org/10.1016/j.jmig.2013.05.002 Salim R, Riris S, Saab W (2012) Adenomyosis reduces pregnancy rates in infertile women undergoing IVF. Reprod BioMed Online 25:273–277. https://doi.org/10.1016/j.rbmo.2012.05.003 Saremi A, Bahrami H, Salehian P (2014) Treatment of adenomyomectomy in women with severe uterine adenomyosis using a novel technique. Reprod BioMed Online 28:753–760. https://doi.org/10.1016/j.rbmo.2014.02.008 Yen CF, Basar M, Kizilay G, Lee CL, Kayisli UA, Arici A (2006) Implantation markers are decreased in endometrium of women with adenomyosis during the implantation windows. Fertil Steril 86(1):550. https://doi.org/10.1177/1933719116681515 Pinzauti S, Lazzeri L, Tosti S (2015) Transvaginal sonographic features of diffuse adenomyosis in 18–30-year-old nulligravid women without endometriosis: association with symptoms. Ultras Obstet Gynaecol 46:730–736. https://doi.org/10.1002/uog.14834 Naftalin J, Hoo W, Pateman K, Mavrelos D (2012) How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum Reprod 27:3432–3439. https://doi.org/10.1093/humrep/des332 Chapron C, Tosti C, Marcellin L (2017) Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes. Hum Reprod 32:1393–1401. https://doi.org/10.1093/humrep/dex088 Puente JM, Fabris A, Patel J (2016) Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease. Reprod Biol Endocrinol 14:60–65. https://doi.org/10.1186/s12958-016-0185-6 Kunz C (2005) Adenomyosis in endometriosis-prevalence and impact on fertility: evidence from magnetic resonance imaging. Hum Reprod 20(8):2309–2316. https://doi.org/10.1093/humrep/dei021 Vered H, Eisenberg E (2017) Sonographic signs of adenomyosis are prevalent in women undergoing surgery for endometriosis and may suggest a higher risk of infertility. BioMed Res Intern. https://doi.org/10.1155/2017/8967803 Tremellen K, Thalluri V (2013) Impact of adenomyosis on pregnancy rates in IVF treatment. Reprod BioMed Online 26(3):299–300. https://doi.org/10.1016/j.rbmo.2013.01.013 Bruun MR (2018) Endometriosis and adenomyosis are associated with increased risk of preterm delivery and a small for gestational age child: a systematic review and meta-analysis. Acta Obstet Gynecol Scand 97(9):1073–1090. https://doi.org/10.1111/aogs.13364 Chapron C, Vannuccini S, Santulli P, Abrão MS, Carmona F, Fraser IS, Gordts S, Petraglia F (2020) Diagnosing adenomyosis: an integrated clinical and imaging approach. Hum Reprod Update 26(3):392–411. https://doi.org/10.1093/humupd/dmz049 Taylor HS, Kotlyar AM, Flores VA (2021) Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet 397(10276):839–852. https://doi.org/10.1016/S0140-6736(21)00389-5 Bourdon M, Santulli P, Kateb F, Pocate-Cheriet K, Batteux F, Maignien C, Chouzenoux S, Chapron C (2021) Adenomyosis is associated with specific proton nuclear magnetic resonance (1H-NMR) serum metabolic profiles. Fertil Steril 116(1):243–254. https://doi.org/10.1016/j.fertnstert.2021.02.031 Wang S, Li B, Duan H, Wang Y, Shen X, Dong Q (2021) Abnormal expression of connective tissue growth factor and its correlation with fibrogenesis in adenomyosis. Reprod BioMed Online 42(3):651–660. https://doi.org/10.1016/j.rbmo.2020.11.002 Zhumalina AK, Tusupkaliev BT, Zame YA, Voloshina LV, Darzhanova KB (2020) Clinical and immunological aspects of newborn adaptation born from mothers with intrauterine infection [Aspectos clínicos e imunológicos da adaptação do recém-nascido de mãe com infecção intrauterina]. Period Tche Quim 17(34):656–666 Toichuev RM, Zhilova LV, Paizildaev TR, Khametova MS, Rakhmatillaev A, Sakibaev KS, Madykova ZA, Toichueva AU, Schlumpf M, Weber R, Lichtensteiger W (2018) Organochlorine pesticides in placenta in Kyrgyzstan and the effect on pregnancy, childbirth, and newborn health. Environ Sci Pollut Res 25(32):31885–31894. https://doi.org/10.1007/s11356-017-0962-6 Dobrovanov O, Králinský K (2020) Comparison of effectiveness and sensitivity of prenatal and postnatal sonografic diagnostics of anomalies the uropoetic system in Slovakia [Porovnanie efektivity a senzitivity prenatálnej a postnatálnej sonografickej diagnostiky vrodených vývojových chýb obličiek na slovensku]. Lekarsky Obzor 69(4):130–133 Funding The authors have not disclosed any funding. Author information Authors and Affiliations Corresponding author Ethics declarations Conflict of interest All authors state they have no conflicts of interest. Ethical approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. A study was approved by National Ethics Commission of the Ministry of Health of the Republic of Kazakhstan, No. 5963-1. Consent to participate Agreed to by all participants. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s11010-024-05007-y Rights and permissions Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. About this article Cite this article Moldassarina, R.S., Manabayeva, G.K., Akylzhanova, Z.Y. et al. RETRACTED ARTICLE: The importance of vitamin D in the diagnosis and treatment of adenomyosis. Mol Cell Biochem 478, 571–579 (2023). https://doi.org/10.1007/s11010-022-04533-x Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s11010-022-04533-x