Zn(II) Complexes of a Novel Twisted Carbon-Centred Scorpionate Derived from Bis(thiadiazole)alkanes (CH2(S-tdzMe)2): Synthesis, Structural Characterization and Protein Interaction Studies

Zn(II) Complexes of a Novel Twisted Carbon-Centred Scorpionate Derived from Bis(thiadiazole)alkanes (CH2(S-tdzMe)2): Synthesis, Structural Characterization and Protein Interaction Studies | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Zn(II) Complexes of a Novel Twisted Carbon-Centred Scorpionate Derived from Bis(thiadiazole)alkanes (CH 2 (S-tdz Me ) 2 ): Synthesis, Structural Characterization and Protein Interaction Studies Saravana Kumar Moorthy, Ashok Kumar Saravana Loganthan, Sarathi Natarajan, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6473616/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 08 Sep, 2025 Read the published version in Transition Metal Chemistry → Version 1 posted 16 You are reading this latest preprint version Abstract A series of novel zinc(II) halide complexes with the versatile twisted scorpionate ligand, bis((5-methyl-1,3,4-thiadiazol-2-yl)thio)methane (CH 2 (S-tdz Me ) 2 ) (1), have been synthesized and characterized. The ligand (1) reacts with ZnX 2 (X = Br, Cl, I) in a 1:1 molar ratio to afford the complexes [Zn(CH 2 (S-tdz Me ) 2 )X 2 ] (X = I (2), Br (3), Cl (4)). These complexes, along with the ligand, were characterized by elemental analysis, FT-IR, HRESI-MS, UV-Vis, and multinuclear NMR spectroscopy. Single crystal X-ray diffraction studies of the ligand (1) and complex (4) revealed a tetrahedral geometry around the zinc(II) ion with the ligand coordinating in a κ2N-fashion. Preliminary interaction studies with bovine serum albumin (BSA) using fluorescence spectroscopy suggest potential protein-binding capability. Twisted scorpionate Zinc(II) Complex Eight membered chelate ring Single Crystal XRD Protein Interaction Full Text Additional Declarations No competing interests reported. Supplementary Files CrystalDataStructures1and4.zip Cite Share Download PDF Status: Published Journal Publication published 08 Sep, 2025 Read the published version in Transition Metal Chemistry → Version 1 posted Editorial decision: Revision requested 15 May, 2025 Reviews received at journal 15 May, 2025 Reviews received at journal 11 May, 2025 Reviews received at journal 09 May, 2025 Reviews received at journal 06 May, 2025 Reviews received at journal 06 May, 2025 Reviewers agreed at journal 28 Apr, 2025 Reviewers agreed at journal 26 Apr, 2025 Reviews received at journal 26 Apr, 2025 Reviewers agreed at journal 26 Apr, 2025 Reviewers agreed at journal 25 Apr, 2025 Reviewers agreed at journal 24 Apr, 2025 Reviewers agreed at journal 24 Apr, 2025 Reviewers invited by journal 24 Apr, 2025 Submission checks completed at journal 24 Apr, 2025 First submitted to journal 22 Apr, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6473616","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":448434929,"identity":"bace48a2-6e91-4f36-9b2d-926addaf742e","order_by":0,"name":"Saravana Kumar Moorthy","email":"","orcid":"","institution":"Saraswathi Narayanan College","correspondingAuthor":false,"prefix":"","firstName":"Saravana","middleName":"Kumar","lastName":"Moorthy","suffix":""},{"id":448434930,"identity":"70c74f95-5315-4e22-87c0-9db89e405e98","order_by":1,"name":"Ashok Kumar Saravana Loganthan","email":"","orcid":"","institution":"GRT Institute of Engineering 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