Extreme elevation of serum CA-125 in two women with severe endometriosis: case report

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This case report describes two women with severe endometriosis who presented with extremely elevated serum CA-125, demonstrating that high CA-125 levels do not always indicate ovarian malignancy.

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Abstract

Two women with elevated preoperative serum CA-125 levels were found to have extensive endometriosis - one, the highest level related to endometriosis ever reported in the English literature. Endometriosis was found to be etiologic as seen by the prompt reduction in serum CA-125 levels following surgical treatment limited to endometriosis. Thus, a very high CA-125 level does not necessarily forebode ovarian malignancy.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Endometriosis Acute Disease Adult Antigens, Tumor-Associated, Carbohydrate Endometriosis Female Humans Middle Aged

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Source provenance

europepmc
last seen: 2026-07-01T06:12:12.862213+00:00
pubmed
last seen: 2026-05-13T22:11:54.876058+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine