Endometriosis and oxidative stress. Treatment rationale in endometriosis-associated infertility

A.I. Davydov, M.B. Khabarova, R.I. Chilova, V.A. Lebedev, M.N. Shakhlamova
In: Voprosy ginekologii, akušerstva i perinatologii · 2023 · vol. 22(1) , pp. 69–75 · doi:10.20953/1726-1678-2023-1-69-75 · W4360597159
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This review identifies oxidative stress as a key mechanism in endometriosis development and recommends incorporating antioxidant agents, specifically resveratrol and indole-3-carbinol, into comprehensive treatment strategies to address the condition.

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This review examines the role of oxidative stress in the pathogenesis of endometriosis, highlighting how an imbalance between reactive oxygen species and detoxification mechanisms contributes to disease development. The authors identify resveratrol and indole-3-carbinol as potent antioxidants with anti-inflammatory, anti-proliferative, and immunomodulatory properties that may mitigate these toxic effects. Consequently, the paper argues for the integration of these antioxidant agents into comprehensive treatment protocols to address infertility associated with the condition. This paper is centrally about endometriosis — specifically focusing on oxidative stress mechanisms and antioxidant-based treatment rationales for endometriosis-associated infertility.

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Abstract

Oxidative stress, which reflects an imbalance between the manifestations of reactive oxygen species in the body and a biological system’s ability to readily detoxify the reactive intermediates, is of considerable importance among the mechanisms of endometriosis development. Disturbances in the redox state of cells can lead to toxic effects through the production of peroxides and free radicals. The data presented in this review indicate the necessity to include antioxidant agents capable of suppressing several important manifestations of oxidative stress in the complex of treatment measures for endometriosis. The most active antioxidants include resveratrol, which has anti-inflammatory, anti-proliferative, and immunomodulatory effects. In addition to resveratrol, it is recommended to include indole-3-carbinol, a compound with a multifaceted anti-proliferative effect, in the comprehensive treatment of patients with endometriosis. Conclusion. Endometriosis is a disease of multiple etiology. One of the mechanisms of its development is oxidative stress. Therefore, it is essential to include antioxidant agents in the treatment of patients with endometriosis to relieve the negative manifestations of oxidative stress. Key words: endometriosis, oxidative stress, infertility, resveratrol, indole-3-carbinol
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Endometriosis and oxidative stress. Treatment rationale in endometriosis-associated infertility Aleksandr I. Davydov / Marina B. Khabarova / Raisa A. Chilova / Vladimir A. Lebedev / Marina N. Shakhlamova / Oxidative stress, which reflects an imbalance between the manifestations of reactive oxygen species in the body and a biological system’s ability to readily detoxify the reactive intermediates, is of considerable importance among the mechanisms of endometriosis development. Disturbances in the redox state of cells can lead to toxic effects through the production of peroxides and free radicals. The data presented in this review indicate the necessity to include antioxidant agents capable of suppressing several important manifestations of oxidative stress in the complex of treatment measures for endometriosis. The most active antioxidants include resveratrol, which has anti-inflammatory, anti-proliferative, and immunomodulatory effects. In addition to resveratrol, it is recommended to include indole-3-carbinol, a compound with a multifaceted anti-proliferative effect, in the comprehensive treatment of patients with endometriosis. Conclusion. Endometriosis is a disease of multiple etiology. One of the mechanisms of its development is oxidative stress. Therefore, it is essential to include antioxidant agents in the treatment of patients with endometriosis to relieve the negative manifestations of oxidative stress. Key words: endometriosis, oxidative stress, infertility, resveratrol, indole-3-carbinol For citation: Davydov A.I., Khabarova M.B., Chilova R.I., Lebedev V.A., Shakhlamova M.N. Endometriosis and oxidative stress. Treatment rationale in endometriosis-associated infertility. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2023; 22(1): 69–75. (In Russian). DOI: 10.20953/1726-1678-2023-1-69-75

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