Engineering a Bi-functional Nanoplatform containing FH peptide for Preferential Cardiac Delivery to Counteract Doxorubicin-Induced Cardiotoxicity

Engineering a Bi-functional Nanoplatform containing FH peptide for Preferential Cardiac Delivery to Counteract Doxorubicin-Induced Cardiotoxicity | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Engineering a Bi-functional Nanoplatform containing FH peptide for Preferential Cardiac Delivery to Counteract Doxorubicin-Induced Cardiotoxicity Jun Li, Zheng-long Zhong, Jing Tang, Yi Chen, Chang-pei Xiang, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7574052/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 4 You are reading this latest preprint version Abstract Background DOX, an anthracycline antibiotic, is extensively utilized in the treatment of various solid tumors and hematological malignancies but is constrained by its cumulative cardiotoxicity. PDA has emerged as a promising drug delivery platform owing to its superior biocompatibility, pH-responsive drug release capability, and multifunctional surface properties. Methods we conducted a comprehensive evaluation of PDA-Dex/FH, encompassing its physicochemical characteristics, drug release kinetics, in vitro biosafety, and cardiac targeting efficacy. Additionally, we examined its cardioprotective effect against DOX-induced cardiotoxicity and its preservation of antitumor activity in both cellular and murine models. Results Our comprehensive analysis, including spectroscopic Polydopamine nanoparticles FH peptide Biosafety Cardiac targeting efficiency Cardioprotective effect Full Text Cite Share Download PDF Status: Under Review Version 1 posted Reviewers agreed at journal 24 Nov, 2025 Reviewers invited by journal 16 Sep, 2025 Editor assigned by journal 10 Sep, 2025 First submitted to journal 09 Sep, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7574052","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":515697040,"identity":"b3933426-646f-40b2-9b90-1e01e78a6e25","order_by":0,"name":"Jun Li","email":"","orcid":"","institution":"Hospital of Traditional Chinses Medicine and Western Medicine of Panzhihua","correspondingAuthor":false,"prefix":"","firstName":"Jun","middleName":"","lastName":"Li","suffix":""},{"id":515697041,"identity":"eafa6c2a-77ec-43bd-b36f-a6f0fe5f8b15","order_by":1,"name":"Zheng-long Zhong","email":"","orcid":"","institution":"Hospital of Traditional 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PDA has emerged as a promising drug delivery platform owing to its superior biocompatibility, pH-responsive drug release capability, and multifunctional surface properties.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e\u003cp\u003ewe conducted a comprehensive evaluation of PDA-Dex/FH, encompassing its physicochemical characteristics, drug release kinetics, in vitro biosafety, and cardiac targeting efficacy. 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