Abstract
Background: The neutrophil-percentage-to-albumin ratio (NPAR) is a readily accessible biomarker reflecting systemic inflammation and nutritional status. This study aimed to investigate the association between NPAR and serum α-Klotho(a well-established anti‐aging biomarker) levels among the elderly population. Patients and methods: This cross-sectional investigation was carried out among participants from NHANES cycles spanning 2009 to 2016. The data of NPAR were log-transformed (ln-NPAR) to normalize the skewed distribution. The relationship between ln-NPAR and α‐Klotho was investigated using stratified multivariable linear regression. To explore possible non‐linear connection, we employed a generalized additive model, together with smoothed curve fitting. Additionally, subgroup analysis was conducted to assess the strength of the association across various populations. Results: A total of 3986 participants with an average age of 67.57 ± 0.09 years were included after applying exclusion criteria. After adjusted by all covariates, ln-NPAR was negatively associated with serum α‐Klotho concentration [β(95% CI) = -80.47(-129.20,-31.74)]. Furthermore, a significant V‐shaped association between ln-NPAR and klotho protein level was found in fully-adjusted smoothed curve fitting and two-piecewise linear regression, with its inflection point at 2.965 (corresponding to NPAR = 18.39). Subgroup analysis and interaction test indicated no detectable dependence on stratification factors (all p for interaction > 0.05). Conclusions: The logarithmically transformed NPAR exhibited a V-shaped association with serum α-klotho protein concentration in elderly adults in the U.S. Further studies are warranted to validate upon these findings.
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Hanke Xu, Daoran Xu, Yunrong Zhu, et al.
The Association Between Neutrophil-Percentage-to-Albumin Ratio and Serum α-Klotho among the Elderly Populations: A Cross-Sectional Analysis from NHANES 2009–2016. Authorea. 17 March 2025.
DOI: https://doi.org/10.22541/au.174222726.62411563/v1
DOI: https://doi.org/10.22541/au.174222726.62411563/v1
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