Short neonatal treatment of female mice pups with tamoxifen induces severe adenomyosis in adult mice

Vervier, Julie, Squatrito, Marlyne, Nisolle, Michelle, Munaut, Carine
2023 · W7052780132
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A short neonatal treatment of female mouse pups with tamoxifen resulted in the development of severe adenomyosis in the adult mice.

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This study investigates the developmental origins of adenomyosis by administering a short course of tamoxifen to female mouse pups during the neonatal period. The researchers observed that this early-life exposure led to the development of severe adenomyosis in the adult mice, characterized by the presence of endometrial glands and stroma within the myometrium. The findings suggest that transient hormonal disruptions during critical developmental windows can permanently alter uterine architecture and predispose individuals to this condition later in life. This paper is centrally about adenomyosis — specifically, it presents an experimental mouse model demonstrating that neonatal tamoxifen exposure induces severe adenomyosis in adulthood.

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Poster (Scientific congresses and symposiums) Short neonatal treatment of female mice pups with tamoxifen induces severe adenomyosis in adult mice ; ; et al. 2023 • ESGE 32nd Annual Congress Permalink https://hdl.handle.net/2268/318577 https://hdl.handle.net/2268/318577 ESGE_Official_Abstract_Publication_2023.pdf Publisher postprint (14.18 MB) All documents in ORBi are protected by a user license. copy to clipboard copied Disciplines : Reproductive medicine (gynecology, andrology, obstetrics) Vervier, Julie ; Centre Hospitalier Universitaire de Liège - CHU > > Service de gynécologie-obstétrique (CHR) Squatrito, Marlyne ; Université de Liège - ULiège > GIGA > GIGA Cancer - Tumours and development biology Nisolle, Michelle ; Centre Hospitalier Universitaire de Liège - CHU > > Service de gynécologie-obstétrique (CHR) Munaut, Carine ; Université de Liège - ULiège > GIGA > GIGA Cancer - Tumours and development biology Language : English Title : Short neonatal treatment of female mice pups with tamoxifen induces severe adenomyosis in adult mice Publication date : September 2023 Event name : ESGE 32nd Annual Congress Event date : 01/10/2023 - 04/10/2023 Audience : International Available on ORBi : since 24 May 2024

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