ANTIBODIESTOBENZO [A] PYREN, ESTRADIOL AND PROGESTERON IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS

Виталий Олегович Червов, Н. В. Артымук, Лариса Николаевна Данилова, Е. Г. Поленок
In: Mother and Baby in Kuzbass; № 4 (2018): декабрь; 31-36 · 2018 · W4404666817
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Women with endometriosis exhibited higher IgA and IgG antibody levels to estradiol, progesterone, and benzo[a]pyrene compared to controls, potentially linked to increased exposure from smoking.

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This retrospective case-control study enrolled 200 women to compare immune responses to hormone-like xenobiotics and sex steroids, measuring serum IgA and IgG antibodies to benzo[a]pyrene, estradiol, and progesterone using a non-competitive enzyme immunoassay. The study included 100 women with externally genital endometriosis and 100 women with tubal-origin infertility, and it identified antibody threshold values associated with increased risk. Women with endometriosis had higher exposure to endocrine-disrupting chemicals linked to smoking and showed significantly higher IgA and IgG antibody levels to steroid hormones and benzo[a]pyrene than controls. The paper’s limitation is that the antibody findings and exposures are assessed retrospectively and comparatively rather than demonstrating a direct causal mechanism; This paper is centrally about endometriosis — it evaluates serum antibody immune responses to benzo[a]pyrene and sex steroids in women with external genital endometriosis.

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Abstract

Objective – to study the social and household characteristics and specific immune responses to hormone-like xenobiotics and sex steroids in women with endometriosis. Materials and methods. A retrospective case-control study was conducted. The study included 200 women. Group I – women with a verified diagnosis of IEG (n = 100), Group II – women with tubal genesis infertility (n = 100). Using non-competitive enzyme immunoassay, all women in the studied groups studied serum antibodies (AT) of the IgA and IgG class specific for benzo[a]pyrene (BP), estradiol (ES) and progesterone (PG). The threshold values of antibodies associated with an increased risk of endometriosis were identified. The results. Women with endometriosis are more often subject to increased exposure to EDS, due to active and passive smoking. In patients with endometriosis, the levels of IgA and IgG antibodies to steroid hormones and benzo[a]pyrene are statistically significantly higher. Conclusion. The effects of EDS can be considered a risk factor for endometriosis.
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Abstract

Objective – to study the social and household characteristics and specific immune responses to hormone-like xenobiotics and sex steroids in women with endometriosis.

Materials

and methods. A retrospective case-control study was conducted. The study included 200 women. Group I – women with a verified diagnosis of IEG (n = 100), Group II – women with tubal genesis infertility (n = 100). Using non-competitive enzyme immunoassay, all women in the studied groups studied serum antibodies (AT) of the IgA and IgG class specific for benzo[a]pyrene (BP), estradiol (ES) and progesterone (PG). The threshold values of antibodies associated with an increased risk of endometriosis were identified. The results. Women with endometriosis are more often subject to increased exposure to EDS, due to active and passive smoking. In patients with endometriosis, the levels of IgA and IgG antibodies to steroid hormones and benzo[a]pyrene are statistically significantly higher. Conclusion. The effects of EDS can be considered a risk factor for endometriosis.

Keywords

Article Details Information about financing and conflict of interests The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article. This work is licensed under a Creative Commons Attribution 4.0 License. How to Cite

References

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