ANTIBODIESTOBENZO [A] PYREN, ESTRADIOL AND PROGESTERON IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS

This retrospective case-control study enrolled 200 women to compare immune responses to hormone-like xenobiotics and sex steroids, measuring serum IgA and IgG antibodies to benzo[a]pyrene, estradiol, and progesterone using a non-competitive enzyme immunoassay. The study included 100 women with externally genital endometriosis and 100 women with tubal-origin infertility, and it identified antibody threshold values associated with increased risk. Women with endometriosis had higher exposure to endocrine-disrupting chemicals linked to smoking and showed significantly higher IgA and IgG antibody levels to steroid hormones and benzo[a]pyrene than controls. The paper’s limitation is that the antibody findings and exposures are assessed retrospectively and comparatively rather than demonstrating a direct causal mechanism; This paper is centrally about endometriosis — it evaluates serum antibody immune responses to benzo[a]pyrene and sex steroids in women with external genital endometriosis.

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