Therapeutic potential of traditional Chinese medicine for vascular endothelial growth factor.

Vascular endothelial growth factor (VEGF) is the main regulator of physiological angiogenesis during embryonic development, bone growth, and reproductive function, and it also participates in a series of pathological changes. Traditional Chinese medicine (TCM), with a history of more than 2000 years, has been widely used in clinical practice, while the exploration of its mechanisms has only begun. This review summarizes the research of recent years on the influence of TCM on VEGF. It is found that many Chinese medicines and recipes have a regulatory effect on VEGF, indicating that Chinese medicine has broad prospects as a complementary and alternative therapy, providing new treatment ideas for clinical applications and the theoretical basis for research on the mechanisms of TCM. 概要 血管内皮生长因子是胚胎发育、骨骼生长、生殖功能等过程中生理性血管生成的共同调节因子, 同时也参与一系列的病理变化。中医有2000多年的历史, 在临床上得到了广泛的应用, 但对中医机制的探索才刚刚开始。本文总结了近年来中医药干预血管内皮生长因子的相关研究, 发现许多中药和方剂对血管内皮生长因子具有调节作用, 说明中医药作为补充和替代疗法具有广阔的前景, 为临床提供新的治疗思路, 并为中医药的机制研究提供理论依据。 Similar content being viewed by others

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Lingkai MENG, Yuting LU, Kuo YANG, and Guangze OUYANG supervised the study. Yanran BAN and Shuang CHEN edited the tables, figure, and formats. All authors have read and approved the final manuscript, and therefore, have full access to all the data in the study and take responsibility for the integrity and security of the data. Compliance with ethics guidelines Yijia MAO, Lingkai MENG, Huayi LIU, Yuting LU, Kuo YANG, Guangze OUYANG, Yanran BAN, and Shuang CHEN declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed by any of the authors. Rights and permissions About this article Cite this article Mao, Y., Meng, L., Liu, H. et al. Therapeutic potential of traditional Chinese medicine for vascular endothelial growth factor. J. Zhejiang Univ. Sci. B 23, 353–364 (2022). https://doi.org/10.1631/jzus.B2101055 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1631/jzus.B2101055