Non-Viral Nanovectors Based on Cyclodextrins for siRNA Delivery: An Update to Current Technologies

Gene delivery/administration and, in particular, small interfering RNA (siRNA) delivery represents a therapeutic challenge and very effective carriers have yet to be identified. Cyclodextrins (CDs) are cyclic oligosaccharides with unique host–guest inclusion capabilities, widely recognized in the pharmaceutical field for their ability to enhance drug solubility and bioavailability. Their excellent biocompatibility and chemical ver-satility make them powerful building blocks for the design of supramolecular nano-vectors (NVs). Thanks to their facility of functionalization, CDs are highly versatile and have found numerous applications across various fields. In this contest CD based NVs are currently explored as non-viral agents to transport and release siRNA. Recent studies suggest that self-assembled NVs based on CDs can improve the transfection and safety of siRNA delivery systems. This review provides a comprehensive overview of the most recent advances in the design of NVs based on CDs and their use for delivery of siRNA, discussing the ins and outs of structural differences and chemical functionalization.