Predictive value of preoperative central sensitization phenotype on postoperative pain recurrence etiology and neuromodulation treatment response in endometriosis patients

This prospective observational cohort study mainly focuses on the clinical significance of preoperative central sensitization status assessed by the Central Sensitization Inventory (CSI) in endometriosis patients. The core purpose is to explore whether different preoperative CSI levels can distinguish the etiology of postoperative pain recurrence. Higher preoperative CSI is hypothesized to indicate that postoperative recurrent pain is mainly derived from central sensitization rather than peripheral organic lesions. This study also aims to verify the predictive effect of preoperative CSI on postoperative pain recurrence and further explore its moderating effect on patients’ response to neuromodulation therapy. CSI will be measured before surgery and re-tested during postoperative follow-up to observe dynamic changes of central sensitization.