Associations Among miR-33, APOE ε4, and Metabolic Markers in Down Syndrome Youth

Associations Among miR-33, APOE ε4, and Metabolic Markers in Down Syndrome Youth | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Associations Among miR-33, APOE ε4, and Metabolic Markers in Down Syndrome Youth Kenia Esparza Ocampo, Wendy Gastelum Espinoza, Tasuko Sato Acosta, and 8 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8845542/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Down syndrome (DS), caused by trisomy 21, is associated with intellectual disability and early metabolic and neurodegenerative alterations. Cholesterol homeostasis, regulated by microRNAs (miRNAs), miR-33 through ABCA1 and HDL cholesterol (HDL-c) biogenesis, influences cognitive decline linked to the APOE ε 4 isoform. Methods A cross-sectional study was conducted in 50 children and adolescents with Down syndrome (3–18 years) and matched controls, measuring miR-33a/b expression, lipid profiles, thyroid function, and APOE genotypes Statistical analyses included correlation and multivariate regression tests (p < 0.05). Results We found significantly reduced miR-33a/b levels and lower HDL-c in DS participants, alongside frequent thyroid and glycemic abnormalities. The presence of the APOE ε 4 allele correlated with decreased HDL-c in DS, suggesting a genetic-metabolic interaction contributing to neurological vulnerability. Conclusions These findings suggest that dysregulation of miR-33 cknand thyroid hormones, combined with APOE ε4 status, may underlie early metabolic disturbances and increased neurodegenerative risk in DS, highlighting potential targets for personalized preventive and therapeutic strategies. Registration : The study protocol was reviewed and approved by the Ethics Committee of the Faculty of Medicine, Autonomous University of Sinaloa, with registration number CEI-FM-PI-2023-009, in accordance with current ethical standards and regulations. miR-33 APOE ε4 HDL cholesterol thyroid hormones Down syndrome Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Background Down syndrome (DS) is a genetic disorder resulting from an additional copy of chromosome 21, either partial or complete, leading to trisomy, characterized by intellectual disability and distinctive phenotypic features (1). Its global incidence ranges from 1 in 1,000 to 1 in 1,100 live births. In 2021, the worldwide prevalence was estimated at 19.9 per 100,000 inhabitants, corresponding to approximately 1.57 million individuals living with DS (2). Advanced maternal age (>35 years) has been identified as a major risk factor for congenital chromosomal abnormalities, including DS (1). Over the past decades, advances in prevention, diagnosis, and management of comorbidities have markedly improved the life expectancy of individuals with DS, from about 5 years in the 1950s to nearly 60 years today (3-5). The characteristic phenotype of trisomy 21 reflects the consequences of genomic imbalance. Chromosome 21 sequencing and experimental models in humans, mice, and cell cultures have substantially contributed to understanding the molecular repercussions of this additional genetic material (6-8). MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression and are implicated in essential biological processes, including lipid metabolism and the pathophysiology of cardiovascular and neurodegenerative diseases (9). Among them, miR-33, encoded within the introns of SREBF2 and SREBF1 , modulates HDL cholesterol (HDL-c) biogenesis and excretion by regulating ABCA1 expression as well as bile acid synthesis and secretion (9, 10). In animal models, inhibition of miR-33 elevates plasma HDL-c levels and confers protection against atherosclerosis (11). Regulated expressions of miR-33 may therefore exert protective effects against atherosclerosis and other HDL-c related disorders, representing a potential therapeutic target (11). In individuals with DS, no direct association or specific phenotypic role of miR-33 has been reported. However, given its established role in cholesterol metabolism via ABCA1 regulation and HDL biogenesis, mechanisms also implicated in cognitive decline linked to the APOE ε4 isoform, its potential contribution in DS warrants investigation (10, 12). Evidence from animal and human models indicates that miR-33 regulates lipid transport and oxidation pathways by interacting with genes such as ABCA1 and SREBP , thereby modulating HDL biogenesis and cholesterol flux at the tissue level. Moreover, the functional connection between miR-33 and brain lipid-regulatory systems underscores the integration of miRNA signaling with proteins such as APOE and transporters, including ABCA1, in maintaining cerebral lipid homeostasis and neuroprotection. Dysregulation of miR-33 and APOE may therefore jointly impair cholesterol metabolism and β-amyloid processing, offering novel therapeutic and diagnostic perspectives for neurodegenerative diseases associated with HDL-c (13, 14). Plasma HDL-c levels and the function of lipoproteins such as APOE are essential for vascular integrity, cerebral cholesterol balance, and β-amyloid clearance. Variants of the APOE gene, particularly ε4, have been linked to increased risk of cognitive decline and dementia, especially in individuals with DS, where they accelerate the onset of Alzheimer’s disease, like symptoms, and disrupt cerebral lipid homeostasis (15). Functionally, APOE regulates cerebral cholesterol metabolism, including β-amyloid clearance, through interactions with ABCA1 and lipoprotein receptors (16). It is also a well-established genetic determinant of neurodegenerative diseases such as Alzheimer’s, which manifests earlier in individuals with DS (17, 18). The ε4 isoform has been consistently associated with an increased risk and faster progression of cognitive impairment, whereas ε2 appears to confer a protective effect (17, 19). In people with DS, the ε4 allele is associated with more severe, earlier-onset cognitive decline (19). Thyroid dysfunction is also markedly more prevalent among individuals with DS, occurring at significantly higher rates than in the general population, from childhood through adulthood. These disorders tend to appear earlier and have a pronounced impact on neurological development. Combined with genetic factors such as APOE ε4, thyroid dysfunction may potentiate or accelerate cognitive deterioration in this population (20). Given the high prevalence of dyslipidemias characterized by low HDL-c levels, frequent thyroid abnormalities, and the genetic predisposition conferred by APOE variants in DS, along with the regulatory role of miR-33 in lipid metabolism, it is essential to investigate the interactions among these factors. Their combined influence may contribute to early cognitive decline in DS (9, 17, 21). Understanding these mechanisms could help identify specific biomarkers and therapeutic targets to mitigate cognitive deterioration and cardiovascular comorbidities in this population. Methods Study design A cross-sectional study with a descriptive, correlational design was conducted to compare individuals with DS with healthy control participants (CTRL). Written informed consent was obtained from the parents or legal guardians of all participants. All collected data were anonymized to ensure confidentiality. The study protocol was reviewed and approved by the Ethics Committee of the Faculty of Medicine, Autonomous University of Sinaloa, with registration number CEI-FM-PI-2023-009, in accordance with current ethical standards and regulations. Study population Initially, 91 individuals with a confirmed diagnosis of DS were recruited through an open social media call. Eligible participants included individuals with a history of thyroid disorders or prior surgical procedures. Exclusion criteria included a previous diagnosis of leukemia, incomplete clinical information, or insufficient blood sample for analysis. After applying inclusion and exclusion criteria, the final study population comprised 50 participants with cytogenetically confirmed DS, aged 3 to 18 years, of both sexes (Figure 1). Additionally, a control group of 50 healthy participants without DS or other known genetic conditions, matched by age and sex, was also enrolled. Anthropometric evaluation Body weight and body fat percentage were measured using a digital scale (Tanita BF689, Tokyo, JP). Height was measured using a stadiometer (SECA 2013, Birmingham, UK), and waist and hip circumferences were measured using a metallic tape (Lufkin, Apex Tool Group, Sparks, MD, USA). All measurements were taken with participants barefoot and wearing light clothing, following standardized procedures established by the International Society for the Advancement of Kinanthropometry (ISAK) (22). Body mass index (BMI) was calculated as weight (kg) divided by height squared (m 2 ). BMI in the DS group was classified using age-appropriate percentile tables from the National Institute of Pediatrics (INP): 95 th , obesity (23). For the CTRL group, BMI-for-age percentiles were determined according to the Centers for Disease Control and Prevention (CDC): 95 th , obesity (24). Biochemical evaluation Peripheral blood was collected via venipuncture after 10-12 hours of overnight fasting into EDTA and SST tubes, centrifuged at 3500 rpm for 10 min, and stored at –80°C until analysis. Serum concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and HDL-c were determined using an enzymatic colorimetric method (RANDOX Laboratories Ltd., Antrim, UK). Dyslipidemia was defined according to the National Cholesterol Education Program (NCEP) criteria for children and adolescents: TC ≥ 200 mg/dL; TG ≥ 100 mg/dL (0–9 years) or ≥130 mg/dL (≥10 years); HDL-c < 40 mg/dL; and LDL-c ≥ 130 mg/dL (25). Atherogenic risk was estimated using the TC/HDL-c ratio and the logarithmic TG/HDL-c index (26). Glucose and glycated hemoglobin (HbA1c) were measured by enzymatic colorimetry (RANDOX Laboratories Ltd., Antrim, UK) and classified according to the American Diabetes Association (ADA) criteria: glucose ≥126 mg/dL and HbA1c ≥6.5% as thresholds for diabetes risk. MiRNA quantification Plasma miRNAs were extracted using the phenol-based TRIzol reagent (Invitrogen Life Technologies) from 200 µL of plasma per participant. Extracted RNA was diluted in 8 µL of RNase-free water and stored at –80°C. cDNA synthesis was performed with the miRCURY™ LNA™ RT Kit (QIAGEN Cat. No. 339340) in a 10 µL reaction containing 7 µL of purified RNA. Reaction conditions were as follows: reverse transcription at 45°C for 60 min, inactivation at 95°C for 5 min, and storage at 4°C. Quantification of miR-33a-5p (miR-33a) and miR-33b-3p (miR-33b) expression was performed by real-time quantitative PCR (qPCR) using the miRCURY LNA SYBR® Green PCR Kit (QIAGEN, Hilden, Germany), following the manufacturer’s protocol. SNORD48 was used as the endogenous control (12, 27). Reactions were run on a StepOnePlus TM Real-Time PCR System (Applied Biosystems) under the following conditions: 95°C for 2 min; 40 cycles of 95°C for 10 s; and melt curve stage of 95°C for 15 s, 60°C for 1 min, and a gradual temperature increase of 0.3°C per step, and a final denaturation at 95°C for 15 seconds, during which fluorescence data were continuously collected. PCR efficiencies were calculated using LinRegPCR software (28). APOE genotyping Genomic DNA was extracted from blood leukocytes using the DNeasy Blood & Tissue Kit (QIAGEN, Cat. 69504, Hilden, Germany). Allelic discrimination of APOE isoforms was performed by real-time PCR using TaqMan® probes (29) on a StepOnePlus TM Real-Time PCR System (Applied Biosystems). The analyzed variants were rs429358 and rs7412, located in exon 4 of the APOE gene, which together determine the ε2, ε3, and ε4 alleles. Genotype analysis was performed using TaqMan Genotyper Software (30, 31). Statistical analysis Normality of data distribution was assessed using the Kolmogorov–Smirnov test. Continuous variables are presented as mean ± standard deviation (SD). Between-group comparisons were conducted using paired or unpaired Student’s t -tests for parametric data, and Mann–Whitney or Wilcoxon tests for nonparametric data. Categorical variables were analyzed using the chi-square test (χ²). Measures of central tendency and dispersion were calculated for all quantitative variables. Pearson or Spearman correlation coefficients were applied depending on data distribution, and multiple linear regression analyses were performed to assess associations between HDL-c and key anthropometric and biochemical parameters. Statistical analyses were conducted using GraphPad Prism 8.0 and SPSS version 25.0, with p < 0.05 considered significant. Results Study population The study included 50 individuals with DS (DS group) and 50 age- and sex-matched individuals without DS (CTRL group). Sixty-two percent of the participants were male, with ages ranging from 3 to 18 years (mean age of 10.0 ± 3.7 years). In the DS group, karyotype analysis revealed that 96% of participants had full trisomy 21, 2% had a translocation, and another 2% exhibited mosaicism (Table 1). Table 1. General characteristics of the study groups Variable CTRL group n (%) DS group n (%) Age (years) 10.0 ± 3.7 10.0 ± 3.7 Sex Male 31 (62.0) 31 (62.0) Female 19 (38.0) 19 (38.0) Karyotype Full trisomy 21 - 48 (96.0) Translocation - 1 (2.0) Mosaicism - 1 (2.0) Values are presented as mean ± standard deviation (SD). CTRL: control; DS: Down syndrome. Anthropometric characteristics Participants with DS showed significantly lower mean body weight and height compared to controls (34.4 ± 15.6 vs. 41.9 ± 21.9 kg, p = 0.0028; 125.1 ± 17.7 vs. 141.0 ± 20.1 cm, p = 0.0001, respectively). No significant differences were observed in BMI, waist, or hip circumference between groups (Table 2). Table 2. Anthropometric characteristics of the study groups Variable CTRL group Mean ± SD DS group Mean ± SD p value Weight (kg) 41.9 ± 21.9 34.4 ± 15.6 0.0028 Heigh (cm) 141.0 ± 20.1 125.1 ± 17.7 0.0001 BMI (kg/m²) 20.8 ± 5.3 19.7 ± 6.1 0.1053 Waist (cm) 65.8 ± 13.9 65.0 ± 15.3 0.8905 Hip (cm) 77.4 ± 17.1 75.4 ± 14.8 0.2959 %Fat (%) 22.8 ± 9.3 24.8 ± 9.3 0.4446 CTRL: control; DS: Down syndrome; BMI: body mass index; %Fat: body fat percentage. p < 0.05 was considered statistically significant. Although BMI did not differ significantly, a higher proportion of DS participants have overweight or obesity (38%) compared to controls (24%), while the proportion with a healthy weight was greater in the CTRL group (70% vs. 60%). Biochemical characteristics Biochemical analysis revealed that individuals with DS had significantly lower HDL-c concentrations than controls (47.5 ± 13.3 vs. 55.5 ± 13.7 mg/dL, p = 0.0047) and higher TG levels (97.6 ± 38.4 vs. 75.9 ± 36.0 mg/dL, p = 0.0139 ). TC did not differ significantly; however, the TC/HDL-c ratio was higher in the DS group (3.6 ± 2.2 vs. 2.9 ± 0.6, p = 0.0181). The plasma atherogenic index (PAI) was also elevated in DS ( p = 0.0007), suggesting increased cardiovascular risk. Thyroid function parameters (TSH, free and total T4, total T3) showed significant differences between groups (Table 3). Table 3. Biochemical concentrations in the study groups Variable CTRL group Mean ± SD DS group Mean ± SD p value TC (mg/dL) 160.0 ± 32.4 155.8 ± 31.4 0.5369 TG (mg/dL) 75.9 ± 36.0 97.6 ± 38.4 0.0139 HDL-c (mg/dL) 55.5 ± 13.7 47.3 ± 13.3 0.0047 LDL-c (mg/dL) 89.2 ± 21.5 88.8 ± 26.9 0.9391 VLDL-c (mg/dL) 14.6 ± 6.3 19.9 ± 8.6 0.0035 TC/HDL-c 2.9 ± 0.6 3.6 ± 2.2 0.0181 IAP [Log(TG/HDL-c)] 0.1 ± 0.2 0.2 ± 0.2 0.0007 Glucose (mg/dL) 92.1 ± 14.8 92.6 ± 7.7 0.4850 HbA1c (%) 5.1 ± 0.3 5.1 ± 0.4 0.6431 Uric acid (mg/dL) 3.9 ± 1.1 5.2 ± 0.9 0.0001 Urea (mg/dL) 21.1 ± 7.1 27.9 ± 6.7 0.0001 Creatinine (mg/dL) 0.4 ± 0.1 0.5 ± 0.1 0.0068 TSH (mg/dL) 2.4 ± 1.5 3.8 ± 2.3 0.001 Free T4 (mg/dL) 1.1 ± 0.1 1.2 ± 0.2 0.0134 Total T4 (mg/dL) 7.7 ± 1.6 8.7 ± 2.0 0.0043 Free T3 (mg/dL) 4.6 ± 1.0 4.8 ± 0.7 0.3699 Total T3 (mg/dL) 142.8 ± 30.6 122.8 ± 26.5 0.0036 miR-33a 1.5 ± 1.2 0.9 ± 1.9 0.0047 miR-33b 1.6 ± 1.4 133.4 ± 727.0 (0.6 ± 1.6) 0.5043 CTRL: control; DS: Down syndrome; TC: total cholesterol; TG: Triglycerides; HDL-c: HDL cholesterol; LDL-c: LDL cholesterol; VLDL-c: VLDL cholesterol; IAP: plasma atherogenic index; HbA1c: glycated hemoglobin; TSH: thyroid-stimulating hormone; T4: thyroxine; T3: triiodothyronine; IAP: plasma atherogenic index. p < 0.05 was considered statistically significant. The DS group showed a greater frequency of dyslipidemias (hypertriglyceridemia, low HDL-c, and high LDL-c) and thyroid dysfunction compared to controls, although not all reached statistical significance. The atherogenic risk was significantly higher in DS ( p = 0.0001), with 66% classified as high risk versus 30% in the CTRL group (Table 4). Table 4. Categorical classification of variables of interest Variable CTRL (n=50) DS (n=50) p value BMI 0.0156 Underweight (%) 6 2 Normal weight (%) 70 60 Overweight/Obesity (%) 24 38 Dyslipidemias 0.0631 Hypercholesterolemia (%) 12 10 Hypertriglyceridemia (%) 14 28 Low HDL-c (%) 12 24 High LDL-c (%) 2 8 Thyroid disorders (%) 0.0001 Hypothyroidism (%) 0 48 Hyperthyroidism (%) 0 4 Low/High TSH (%) 6 34 Low/High free T4 (%) 2 2 Low/High total T4 (%) 4 4 Low/High free T3 (%) 73 58 Low/High total T3 (%) 16 6 Atherogeneity 0.0001 Low risk (%) 52 22 Medium risk (%) 16 12 High risk (%) 30 66 The values represent percentages (%). CTRL: control, DS: Down syndrome, BMI: Body mass index, HDL-c: HDL cholesterol, LDL-c: LDL cholesterol, TSH: thyroid-stimulating hormone, T4: thyroxine, T3: triiodothyronine. p < 0.05 was considered significant. Expression levels of miR-33a and miR-33b Expression of both miR-33a and miR-33b was significantly lower in the DS group compared with controls ( p < 0.0001 for boths). (Figure 1a). Median relative expression was 0.044 vs. 1.077 for for miR-33a and 0.145 vs. 1.322 for miR-33b (Figure 2a and 2b). Age-stratified analysis (3–11 and 12–18 years) confirmed these trends. In both age groups, miR-33a expression remained lower in DS. For miR-33b, expression was also reduced in younger DS participants (Figure 3a) but showed a relative increase in the 12–18 years subgroup (Figure 3b). APOE genotyping APOE genotyping was performed in 30 DS and 40 CTRL samples. The ε3/ε3 genotype was the most frequent (DS: 73.6%; CTRL: 67.5%). The ε4/ε4 genotype was rare (2.6% in both groups). The ε4 allele frequency was similar (DS: 11.8%, CTRL: 12.5%) (Table 5). Table 5. APOE genotypic and allelic frequencies Genotype frequency Allele frequency CTRL DS CTRL DS Genotype n % n % Allele n % n % ε2/ε2 0 0.0 1 2.6 ε2 4 5.0 5 6.6 ε2/ε3 4 10.0 1 2.6 ε3 66 82.5 62 81.6 ε2/ε4 0 0 2 5.6 ε4 10 12.5 9 11.8 ε3/ε3 27 67.5 28 73.6 Total 80 100 76 100 ε3/ε4 8 20.0 5 13.0 ε4/ε4 1 2.5 1 2.6 Total 40 100 38 100 The values represent the number of individuals with each genotype, the total number of alleles (n), and the percentage (%). CTRL: control, DS: Down syndrome, APOE : apolipoprotein E. In carriers of the ε4/ε4 genotype, HDL-c concentrations were lower in DS (43.0 mg/dL) than in controls (63.5 mg/dL, p = 0.0002) (Figure 4). When grouped by ε4 allele carriage, the mean HDL-c was lower in the at-risk DS subgroup (41.1 mg/dL) compared to the non-risk subgroup (48.4 mg/dL). In contrast, controls carrying ε4 showed higher HDL-c (61.0 mg/dL) than non-carriers (50.7 mg/dL) (Figure 5). miR-33a and miR-33b expression were also influenced by APOE genotype. DS individuals carrying the ε4 risk allele exhibited higher expression of miR-33a (1.567 vs. 0.701) and miR-33b (2.170 vs. 0.585) than non-carriers. These differences were less pronounced in controls (Figure 6b). Correlation of variables of interest In the DS group, free T3 was positively correlated with body fat percentage (r = 0.580, p = 0.002), while total T4 was negatively correlated with HDL-c (r = –0.331, p = 0.021). HbA1c correlated negatively with TC (r = –0.280, p = 0.049) and positively with HDL-c (r = 0.405, p = 0.004) and creatinine (r = 0.479, p < 0.001). miR-33a correlated positively with TSH (r = 0.318, p = 0.036), and negatively with free T3 (r = –0.349, p = 0.040). miR-33b correlated positively with TC (r = 0.298, p = 0.040) and negatively with waist circumference (r = –0.348, p = 0.040) (Table 6). In contrast, in controls, total T3 and free T4 correlated negatively with TC (r = –0.341, p = 0.016; r = –0.318, p = 0.026, respectively). HbA1c showed negative correlations with HDL-c (r = –0.372, p = 0.009) and total T4 (r = –0.382, p = 0.007), and a positive correlation with the atherogenic index (r = 0.341, p = 0.016) (Table 7). Table 6. Correlation analysis between anthropometric and biochemical variables and miR-33 in the DS group. Variable 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 1 Age (years) r 1 p 2 Height (cm) r .928** 1 p 0.000 3 Weight (kg) r .901** .882** 1 p 0.000 0.000 4 %Fat (%) r -0.145 -0.168 0.356 1 p 0.452 0.383 0.058 5 Waist (cm) r .644** .612** .720** 0.315 1 p 0.000 0.000 0.000 0.096 6 Hip (cm) r .839** .815** .969** .502** .743** 1 p 0.000 0.000 0.000 0.006 0.000 7 CT (mg/dL) r -0.154 -0.155 -0.082 0.241 -0.052 -0.106 1 p 0.284 0.284 0.573 0.207 0.723 0.467 8 TG (mg/dL) r 0.155 0.128 0.214 0.316 0.236 0.204 .537** 1 p 0.281 0.376 0.135 0.095 0.102 0.159 0.000 9 HDL-c (mg/dL) r 0.116 0.173 0.105 -0.134 0.034 0.047 0.207 -0.245 1 p 0.421 0.230 0.468 0.487 0.818 0.747 0.150 0.086 10 LDL-c (mg/dL) r -0.259 -.283* -0.193 0.256 -0.124 -0.190 .901** .452** -0.176 1 p 0.070 0.047 0.179 0.180 0.394 0.192 0.000 0.001 0.221 11 TC-HDL-c r -0.038 0.025 0.030 0.072 0.129 0.058 -0.127 0.104 -0.259 -0.048 1 p 0.795 0.864 0.834 0.712 0.378 0.694 0.378 0.471 0.069 0.740 12 Atherogenic risk r -0.096 -0.076 -0.031 0.271 0.141 0.016 0.150 0.213 -0.160 0.191 .760** 1 p 0.509 0.602 0.829 0.155 0.334 0.911 0.300 0.137 0.269 0.183 0.000 13 TSH (mg/dL) r -.300* -0.240 -0.256 -0.039 -0.180 -0.223 0.065 -0.008 0.064 0.018 0.082 0.158 1 p 0.043 0.109 0.086 0.844 0.238 0.141 0.667 0.956 0.675 0.907 0.587 0.296 14 Free T3 (mg/dL) r 0.036 0.148 0.218 .580** 0.017 0.230 0.148 0.002 0.284 0.020 -0.295 -0.061 -0.146 1 p 0.835 0.391 0.201 0.002 0.923 0.183 0.389 0.992 0.094 0.906 0.081 0.724 0.394 15 Total T3 (mg/dL) r -0.329 -0.236 -0.300 0.148 -0.254 -0.271 0.240 -0.172 0.159 0.224 -0.003 0.102 -0.066 .593** 1 p 0.050 0.166 0.076 0.462 0.141 0.115 0.158 0.316 0.353 0.189 0.985 0.555 0.704 0.000 16 Free T4 (mg/dL) r -0.088 -0.174 -0.084 0.080 -0.005 -0.112 0.019 0.128 -0.146 0.072 0.040 -0.020 -0.040 -.341* -0.086 1 p 0.546 0.232 0.566 0.685 0.971 0.450 0.897 0.382 0.318 0.625 0.785 0.892 0.791 0.042 0.619 17 Total T4 (mg/dL) r -0.067 -0.067 -0.064 -0.047 0.022 -0.078 0.093 0.198 -.331* 0.200 -0.021 -0.081 -0.072 -0.076 0.083 .621** 1 p 0.650 0.649 0.666 0.815 0.884 0.601 0.530 0.176 0.021 0.174 0.889 0.583 0.636 0.659 0.631 0.000 18 Creatinine (mg/dL) r .801** .752** .757** -0.194 .456** .722** -0.138 0.148 0.169 -0.278 -0.106 -0.175 -0.248 0.180 -0.207 -0.204 -0.186 1 p 0.000 0.000 0.000 0.312 0.001 0.000 0.340 0.306 0.240 0.050 0.464 0.223 0.097 0.293 0.227 0.159 0.206 19 Urea (mg/dL) r 0.015 0.002 0.005 -0.119 0.150 0.017 -0.004 -0.099 0.156 -0.064 -0.021 -0.141 -0.097 -0.032 0.199 -0.030 0.086 0.028 1 p 0.917 0.992 0.970 0.539 0.303 0.908 0.981 0.496 0.280 0.657 0.883 0.327 0.519 0.855 0.245 0.837 0.563 0.846 20 Uric acid (mg/dL) r .506** .469** .576** 0.016 .391** .511** -0.057 0.224 0.111 -0.183 -0.211 -0.173 -0.256 0.036 -0.264 0.027 -0.027 .591** -0.106 1 p 0.000 0.001 0.000 0.934 0.008 0.000 0.706 0.134 0.462 0.223 0.159 0.250 0.098 0.834 0.120 0.858 0.860 0.000 0.483 21 HbA1c (%) r .521** .505** .515** -0.172 .487** .480** -.280* -0.244 .405** -.454** 0.072 -0.074 -0.136 0.114 -0.171 -0.123 -0.167 .479** .306* .411** 1 p 0.000 0.000 0.000 0.372 0.000 0.000 0.049 0.087 0.004 0.001 0.618 0.609 0.367 0.510 0.319 0.400 0.256 0.000 0.031 0.005 22 miR-33a r -0.172 -0.176 -0.220 -0.267 -0.197 -0.239 -0.098 -0.251 -0.259 -0.069 -0.024 -0.215 .318* -.349* -0.215 -0.175 -0.108 -0.146 -0.139 -0.139 -0.111 1 p 0.243 0.231 0.132 0.170 0.184 0.106 0.506 0.085 0.076 0.641 0.874 0.142 0.036 0.040 0.216 0.238 0.473 0.323 0.345 0.369 0.452 23 miR-33b r -0.139 -0.184 -0.227 -0.349 -.348* -0.265 .298* -0.109 0.060 .346* 0.113 0.210 0.056 -0.097 0.112 0.036 -0.001 -0.050 -0.144 -0.050 -0.078 0.137 p 0.347 0.211 0.120 0.068 0.017 0.071 0.040 0.462 0.684 0.016 0.444 0.152 0.717 0.581 0.523 0.813 0.993 0.734 0.328 0.744 0.598 0.364 The values represent the correlation coefficient (r). %Fat: body fat percentage; TC: total cholesterol; TG: Triglycerides; HDL-c: HDL cholesterol; LDL-c: LDL cholesterol; TC-HDL-c: total cholesterol/HDL cholesterol ratio; TSH: thyroid-stimulating hormone; T4: thyroxine; T3: triiodothyronine; HbA1c: glycated hemoglobin A1c; miR-33a: miRNA-33a; miR-33b: miRNA-33b. * p < 0.05, ** p < 0.01. Table 7. Correlation analysis between anthropometric and biochemical variables and miR-33 in the CTRL group. Variable 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 1 Age (years) r 1 p 2 Height (cm) r .923** 1 p 0.000 3 Weight (kg) r .781** .881** 1 p 0.000 0.000 4 %Fat (%) r 0.100 0.018 .428** 1 p 0.498 0.903 0.002 5 Waist (cm) r .596** .557** .734** .720** 1 p 0.000 0.000 0.000 0.000 6 Hip (cm) r .789** .765** .708** .523** .814** 1 p 0.000 0.000 0.000 0.000 0.000 7 CT (mg/dL) r 0.022 0.038 0.052 0.053 -0.061 -0.031 1 p 0.880 0.801 0.726 0.719 0.679 0.833 8 TG (mg/dL) r 0.188 0.139 0.278 .488** 0.249 0.234 .531** 1 p 0.196 0.351 0.056 0.000 0.088 0.110 0.000 9 HDL-c (mg/dL) r -0.113 -0.044 -0.154 -0.217 -0.215 -0.175 .666** 0.059 1 p 0.438 0.768 0.296 0.139 0.142 0.234 0.000 0.688 10 LDL-c (mg/dL) r 0.057 0.051 0.115 0.097 -0.029 0.002 .905** .428** .346* 1 p 0.696 0.734 0.438 0.511 0.845 0.992 0.000 0.002 0.015 11 TC-HDL-c r 0.218 0.137 .329* .410** .313* .285* 0.262 .531** -.519** .547** 1 p 0.133 0.359 0.022 0.004 0.030 0.050 0.069 0.000 0.000 0.000 12 Atherogenic risk r 0.210 0.136 .316* .485** .358* .296* 0.161 .848** -.394** 0.211 .705** 1 p 0.147 0.364 0.029 0.000 0.012 0.041 0.268 0.000 0.005 0.146 1.551 13 TSH (mg/dL) r -.505** -.522** -.435** 0.013 -0.272 -.435** -0.023 0.024 -0.003 -0.022 -0.052 -0.004 1 p 0.000 0.000 0.002 0.931 0.062 0.002 0.873 0.872 0.982 0.880 0.721 0.978 14 Free T3 (mg/dL) r -.440** -.413** -0.133 0.152 -0.127 -.291* -.341* -0.169 -.282* -0.278 -0.019 0.005 0.137 1 p 0.002 0.004 0.369 0.303 0.389 0.045 0.016 0.247 0.050 0.053 0.898 0.974 0.347 15 Total T3 (mg/dL) r -.576** -.535** -0.176 -0.007 -0.244 -.508** -0.194 -0.064 -0.191 -0.150 0.014 0.039 0.175 .662** 1 p 0.000 0.000 0.231 0.960 0.095 0.000 0.182 0.660 0.190 0.304 0.923 0.789 0.228 0.000 16 Free T4 (mg/dL) r -0.021 -0.059 0.005 -0.075 0.015 0.032 -.318* -0.192 -0.129 -.332* -0.244 -0.145 0.078 0.207 0.139 1 p 0.884 0.694 0.973 0.614 0.918 0.830 0.026 0.187 0.376 0.020 0.092 0.320 0.592 0.153 0.342 17 Total T4 (mg/dL) r -.289* -.295* 0.044 .317* 0.163 0.000 -0.192 -0.193 -0.124 -0.145 -0.126 -0.111 .314* .457** 0.265 .537** 1 p 0.044 0.044 0.766 0.028 0.269 0.998 0.186 0.183 0.398 0.319 0.388 0.447 0.028 0.001 0.065 0.000 18 Creatinine (mg/dL) r .703** .775** .558** -0.066 .398** .572** .371** 0.230 0.193 .360* 0.204 0.146 -0.254 -.405** -.523** -0.069 -0.139 1 p 0.000 0.000 0.000 0.656 0.005 0.000 0.009 0.112 0.184 0.011 0.160 0.316 0.078 0.004 0.000 0.638 0.342 19 Urea (mg/dL) r -0.065 -0.021 -0.150 -0.205 -0.103 -0.128 0.213 -0.001 0.149 0.226 0.031 -0.081 0.166 -0.196 -0.232 -0.082 -0.195 0.246 1 p 0.655 0.888 0.309 0.162 0.486 0.388 0.141 0.997 0.307 0.118 0.832 0.578 0.254 0.176 0.109 0.578 0.179 0.088 20 Uric acid (mg/dL) r .413** .507** .564** 0.231 .571** .485** 0.117 0.187 0.043 0.086 0.152 0.195 -0.148 -0.004 -0.252 -0.136 0.065 .697** 0.191 1 p 0.003 0.000 0.000 0.114 0.000 0.000 0.424 0.198 0.768 0.556 0.297 0.179 0.310 0.979 0.080 0.350 0.656 0.000 0.190 21 HbA1c (%) r -0.036 0.004 0.054 -0.017 -0.072 -0.029 0.227 .300* -0.049 0.273 .372** .341* -0.151 -0.001 0.165 -0.212 -.382** -0.016 -0.115 0.048 1 p 0.805 0.979 0.715 0.908 0.625 0.846 0.116 0.036 0.740 0.057 0.009 0.016 0.299 0.995 0.257 0.143 0.007 0.916 0.432 0.745 22 miR-33a r 0.075 0.199 0.217 0.014 0.040 0.047 0.007 -0.024 -0.125 0.126 0.053 0.079 0.168 0.061 -0.041 -0.038 0.087 -0.002 -0.202 0.062 -0.185 1 p 0.694 0.309 0.259 0.941 0.836 0.807 0.971 0.898 0.510 0.507 0.780 0.680 0.376 0.747 0.831 0.842 0.648 0.990 0.285 0.745 0.328 23 miR-33b r -0.001 0.130 0.252 0.029 0.172 0.120 0.062 0.038 -0.151 0.122 0.208 0.106 0.234 0.014 0.292 -0.048 -0.038 0.275 0.063 0.236 0.167 -0.221 p 0.994 0.511 0.187 0.883 0.372 0.535 0.746 0.842 0.425 0.522 0.271 0.576 0.214 0.940 0.117 0.800 0.843 0.141 0.741 0.210 0.369 0.349 The values represent the correlation coefficient (r). %Fat: body fat percentage; TC: total cholesterol; TG: Triglycerides; HDL-c: HDL cholesterol; LDL-c: LDL cholesterol; TC-HDL-c: total cholesterol/HDL cholesterol ratio; TSH: thyroid-stimulating hormone; T4: thyroxine; T3: triiodothyronine; HbA1c: glycated hemoglobin A1c; miR-33a: miRNA-33a; miR33-b: miRNA-33b. * p < 0.05, ** p < 0.01. Multiple linear regression In the DS group, multiple regression analysis identified HbA1c as a positive predictor of HDL-c (β = 13.25; 95% CI: 2.53 to 23.9; p = 0.017), whereas total T4 was negatively associated with HDL-c (β = –2.47; 95% CI: –4.92 to –0.02; p = 0.048). No other variables showed significant associations. In the CTRL group, none of the analyzed variables were significantly associated with HDL-c (Table 8). Table 8. Results of multiple linear regression between HDL-c and metabolic variables HDL-c (CTRL) HDL-c (DS) β (IC 95%) p value β (IC 95%) p value HbA1c (%) -2.39 (-16.57 to 11.77) 0.735 13.25 (2.53 to 23.9) 0.017 TSH (mg/dL) 0.217 (-2.60 to 3.04) 0.877 1.81 (-0.25 to 3.88) 0.084 Free T4 (mg/dL) -10.69 (-48.29 to 26.90) 0.569 8.28 (-12.06 to 28.64) 0.412 Total T4 (mg/dL) 0.22 (-3.25 to 3.71) 0.896 -2.47 (-4.92 to -0.02) 0.048 Free T3 (mg/dL) -3.96 (-10.02 to 2.10) 0.194 3.49 (-4.15 to 11.14) 0.358 Total T3 (mg/dL) 0.01 (-0.19 to 0.19) 0.967 0.09 (-0.11 to 0.29) 0.366 Dependent variable: HDL-c. Values represent the regression coefficient (β), 95% confidence intervals (95% CI), and P-values. HDL-c: high-density lipoprotein cholesterol, HbA1c: glycated hemoglobin, TSH: thyroid-stimulating hormone, T4: thyroxine, T3: triiodothyronine. Discussion In this study, we quantified miR-33a and miR-33b expression, HDL-c concentrations, and the frequency of the APOE ε4 genotype in children and adolescents with DS compared with control subjects. The results showed significantly lower expression of both miRNAs in the DS group, accompanied by an unfavorable lipid profile. Individuals with DS had markedly lower mean body weight and height compared with controls (34.4 ± 15.6 kg and 125.1 ± 17.7 cm vs. 40.9 ± 21.9 kg and 141.0 ± 20.1 cm, respectively). This pattern is attributed to hypothalamic–pituitary axis dysfunctions and reduced growth hormone levels (32-35). A higher prevalence of overweight and obesity was observed in DS (38%) compared with controls (25%), consistent with previous reports describing frequent excess weight and its association with metabolic alterations in this population (36, 37). This relationship has been partially explained by the interplay of genetic, hormonal, and behavioral factors that predispose individuals with DS to increased adiposity and dyslipidemia (38). Nevertheless, prevalence estimates vary widely among studies. For instance, one study reported only 15% of participants with DS had overweight or obesity, yet identified a significant association between BMI and triglyceride concentrations (39). This supports the notion that even moderate increases in adiposity contribute substantially to dyslipidemia in DS. Regarding thyroid function and metabolic alterations, our findings align with recent evidence showing higher rates of thyroid dysfunction and metabolic abnormalities in pediatric DS populations (40). DS participants in our study exhibited significantly higher TSH, total and free T4, and total T3 concentrations than controls, suggesting both central and peripheral dysregulation of thyroid function (20). These alterations may contribute to increased susceptibility to metabolic syndrome and disruptions in glucose and lipid metabolism (41). An adverse lipid profile was observed in DS, characterized by lower HDL-c levels and higher TG concentrations, findings consistent with previous studies in DS, including comparisons with unaffected siblings (33, 42, 43). The elevated atherogenic index observed here underscores a higher cardiovascular risk in this group. Altered lipid metabolism may be modulated by dysregulation of miR-33a and miR-33b, known regulators of cholesterol efflux and HDL formation (11). Interestingly, the decreased expression of miR-33 observed in our DS cohort contrasts with studies reporting miR-33 overexpression in dyslipidemic models (11, 14). This discrepancy may stem from methodological differences, particularly the biological matrix analyzed (plasma vs. tissues), as miRNA expression can vary markedly across sample types (44). Subject age and specific genetic and metabolic features of pediatric DS populations, including obesity, may also influence miR-33 expression (45). Unlike previous work examining other miRNAs such as miR-155 and let-7c Pérez-Villarreal, Aviña-Padilla (34), we did not identify significant correlations between miR-33 levels and other measured parameters in controls. The younger age of our participants (3–18 years) may partially explain this difference, suggesting that miR-33 expression could increase with age (34). Overall, these findings indicate that miR-33 regulation is dynamic during development, warranting further investigation to elucidate its role in DS pathophysiology. The presence of the APOE ε4 allele, an established risk factor for Alzheimer’s disease, was associated with lower HDL-c levels in DS, despite similar allele frequencies between groups. This suggests that the impact of ε4 on lipid metabolism may be modulated by the DS genetic background (46). Specifically, DS individuals carrying the ε4/ε4 genotype exhibited markedly lower HDL-c levels than controls with the same genotype (41.1 vs. 61.0 mg/dL, p = 0.0002). This reinforces the hypothesis that gene-environment interactions in DS amplify metabolic and neurological vulnerability (46, 47). Thyroid hormones may modulate the relationship between lipid metabolism and neurodegenerative processes in DS. The positive correlation between free T3 and body fat percentage, and the inverse correlation between total T4 and HDL-c, suggest altered enzymatic regulation within the T3/T4 axis (48). These changes could impair HDL-mediated cholesterol transport, including eflux from brain tissue, potentially compromising neuronal lipid homeostasis. Given that individuals with DS are prone to autoimmune thyroid dysfunction and early neurodegeneration, thyroid dysregulation may intensify chronic inflammation and disrupt central cholesterol balance. Reduced HDL-c concentrations could impair APOE -mediated lipid transport and clearance, thereby heightening neurodegenerative risk (49). Collectively, these mechanisms highlight a complex interplay between thyroid dysfunction, lipid imbalance, and neuronal vulnerability in DS. Understanding these interactions could guide preventive interventions targeting metabolic pathways before irreversible neurodegenerative changes occur. Regression analysis revealed interactions between glycemic and thyroid axes: HbA1c was positively associated with HDL-c (β = 13.25; p = 0.017), while total T4 was negatively associated (β = -2.47; p = 0.048). These results suggest that better glycemic control may enhance HDL-c concentrations and offer neuroprotective benefits, whereas thyroid alterations characteristic of DS could contribute to HDL-c depletion and increased Alzheimer’s risk. Interestingly, HbA1c correlated negatively with TC but positively with HDL-c in DS, in contrast with the atherogenic pattern typically observed in the general population (50). This atypical metabolic phenotype may reflect DS-specific compensatory mechanisms, altered insulin signaling, or distinctive regulation of reverse cholesterol transport. Recent studies support this interpretation, showing that stable HbA1c levels are associated with reduced dementia risk, whereas hyperthyroidism increases susceptibility to Alzheimer’s disease (51, 52). Although similar HbA1c-lipid relationships have been reported in DS (41), our findings provide stronger statistical evidence for this association. The positive correlation between miR-33a and TSH, and its negative correlation with free T3, suggest potential thyroid regulation activity of miR-33a in DS. Although several miRNAs are expressed in thyroid tissue (53), no prior studies have reported such association for miR-33. These findings raise the possibility that miR-33a modulates thyroid-axis-mediated metabolic responses, potentially by regulating genes involved in lipid metabolism (54). The positive correlation between miR-33a and TC, together with its negative correlation with waist circumference, further supports a potential role in adipose redistribution and lipid regulation. Experimental studies in murine DS model have demonstrated tissue-dependent miR-33 expression, with elevated levels in muscle, adipose, and hepatic tissues compared to controls, where expression predominates in adipose tissue (14). Collectively, these findings support the hypothesis that miR-33a may serve as a molecular mediator linking thyroid function, lipid regulation, and body composition in DS. While associations between thyroid hormones and lipids observed in controls reflect typical physiological regulation, in DS these relationships extend to anthropometric and miRNA variables, underscoring a more complex metabolic network. A recent study reported differences in thyroid hormone sensitivity and its associations with metabolic parameters in euthyroid DS children and adolescents compared with controls (40). To our knowledge, this is the first study to simultaneously evaluate miR-33 expression and APOE genotyping in relation to HDL-c and thyroid hormones in a pediatric DS population. By integrating molecular, biochemical, and genetic markers, we reveal novel interactions among miR-33, APOE ε4, and thyroid hormones, providing insight into mechanisms linking metabolic dysfunction to neurological vulnerability. These findings suggest the potential value of early metabolic monitoring and genetic screening strategies in DS, with potential implications for anticipating and preventing neurodegenerative outcomes. These findings suggest the potential value of early metabolic monitoring and genetic screening strategies in DS, with potential implications for anticipating and preventing neurodegenerative outcomes. LIMITATIONS This study has several limitations that should be acknowledged when interpreting the results. The moderate sample size and cross-sectional design limit the ability to establish causal relationships or assess the temporal progression of the observed metabolic and molecular alterations. Moreover, the exclusive assessment of plasma miR-33 expression restricts a comprehensive understanding of its biological behavior, as its levels may vary across tissues and cellular compartments. This underscores the importance of incorporating tissue-based analyses or cellular models in future research to clarify its specific functional role in DS. Another relevant limitation is the low frequency of the APOE ε4 allele in the study cohort, which constrains the statistical power to draw robust conclusions about its genetic impact in this pediatric population. Additionally, age-related variations may influence miR-33 expression. Despite these limitations, the present findings provide a valuable foundation for longitudinal investigations of the metabolic and genetic axes in DS. Future studies should explore the temporal evolution of miR-33 and APOE ε4 in relation to lipid homeostasis, thyroid function, and neurodegenerative risk. Expanding the cohort size will strengthen the generalizability of these results and help define the integrative role of these biomarkers in the metabolic and cognitive health of individuals with DS. Conclusions The findings of this study demonstrate that children and adolescents with Ds exhibit a distinctive metabolic profile characterized by lower expression of miR-33a and miR-33b, reduced HDL-c concentrations, and concomitant thyroid and glycemic alterations. Collectively, these features are associated with metabolic and neurodegenerative risk. The positive correlation between HbA1c and HDL-c, together with the negative association between total T4 and HDL-c, suggests a complex interplay among glucose, lipid, and thyroid regulatory pathways in this population, distinct from the pattern observed in individuals without DS. The association between the APOE ε4 allele and lower HDL-c levels in the DS group further supports a functional interaction between cholesterol transport and neurodegenerative mechanisms linked to Alzheimer’s disease. This reinforces the concept that early metabolic disturbances are associated with neurological vulnerability in individuals with DS. Overall, these results support the hypothesis of altered regulation of cholesterol homeostasis mediated by miR-33 dysregulation and thyroid dysfunction in the context of trisomy 21. They also highlight the importance of further investigating the interaction between miRNAs, genetic risk factors such as APOE ε4, and metabolic pathways connecting lipid metabolism with neurodegeneration. These findings raise the possibility that the identified molecular and metabolic alterations could serve as early biomarkers, which may informe future research on personalized preventive and therapeutic strategies to reduce neurodegenerative risk and improve quality of life in the DS population. Abbreviations The following abbreviations are used in this manuscript: DS: Down syndrome CTRL: Control miRNAs: MicroRNAs miR-33a: miR-33a-5p miR-33b: miR-33b-3p APOE: Apoliporproteín E HDL-c: High-density lipoprotein cholesterol TC: Total cholesterol TG: Triglycerides LDL-c: Low-density lipoprotein cholesterol VLDL-c: Very low-density lipoprotein cholesterol Glu: Glucose HbA1c: Glycated hemoglobin AIP: Atherogenic index of plasma TSH: Thyroid function parameters T4: Thyroxine T3: Triiodothyronine Declarations Ethics approval and consent to participate: The study received approval from the Research Ethics Committee of the Faculty of Medicine, Autonomous University of Sinaloa (registration number CONBIOÉTICA-25-CEI-003-20181012), and was conducted in accordance with the ethical principles established in the Declaration of Helsinki. A written informed consent was obtained from the parent or legal guardian of each participant. Consent for publication: All data were anonymized to protect participant confidentiality. Availability of data and materials: The datasets supporting the findings of this study can be obtained from the principal author ( [email protected] ), upon reasonable request. However, the data is not publicly accessible as it includes information that may compromise the confidentiality of the research participants. Competing interests: The authors declare no competing interests. Funding: This research was funded by the Programa de Fomento y Apoyo a Proyectos de Investi-gación (PROFAPI 2022) under the project entitled “Effect of a Health Education Program for In-dividuals with Down Syndrome on Their Dietary Quality and Blood Metabolic Profile” (Project Code PRO_A3_020). Authors' contributions: Conceptualization: K.E.O., J.M.G. and C.A.R.; Methodology, K.E.O., W.G.E, T.S.A., L.C.Z., A.G.L and C.A.R.; Formal analysis, K.E.O., W.G.E., S.B.O., M.P.V., and R.Z.L.; Investigation, K.E.O., W.G.E., S.A.V. and M.P.V.; Data curation, K.E.O., W.G.E. and T.S.A.; Laboratory analyses: S.B.O., R.Z.L. and T.S.A; Supervision: J.M.G; Writing-original draft preparation: K.E.O. and J.M.G; Writing-review and editing: all authors. Acknowledgements: The author gratefully acknowledges the support of the National Council for Humanities, Science, and Technology (CONAHCYT) through the postgraduate scholarship, which was instrumental in the completion of the master’s degree. Sincere appreciation is also extended to Dr. Carla Angulo Rojo for her invaluable mentorship and generosity throughout this work. References de Graaf G, Buckley F, Skotko BG. Estimation of the number of people with Down syndrome in the United States. Genet Med. 2017;19(4):439-47. Network GBoDC. 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Alzheimers Dement. 2024;20(11):7805-18. Ortega R, Liu B, Persaud SJ. Effects of miR-33 Deficiency on Metabolic and Cardiovascular Diseases: Implications for Therapeutic Intervention. Int J Mol Sci. 2023;24(13). Zhang XZ, Hongbo; Sheng, Qingkai; Liu, Xiaomu; You, Wei; Lin, Haichao; Liu, Guifen. Regulation of microRNA-33, SREBP and ABCA1 genes in a mouse model of high cholesterol. Achieves Animal Breeding. 2021;64. Gorijala P, Aslam MM, Dang LT, Xicota L, Fernandez MV, Sung YJ, et al. Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome. Alzheimers Dement. 2024;20(2):1038-49. Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol. 2013;9(2):106-18. Williams T, Borchelt DR, Chakrabarty P. Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease. Mol Neurodegener. 2020;15(1):8. Zigman WB, Schupf N, Jenkins EC, Urv TK, Tycko B, Silverman W. Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome. Neurosci Lett. 2007;416(3):279-84. Kok E, Haikonen S, Luoto T, Huhtala H, Goebeler S, Haapasalo H, et al. Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age. Ann Neurol. 2009;65(6):650-7. Szybiak-Skora W, Cyna W, Lacka K. Autoimmune Thyroid Disease in Patients with Down Syndrome-Review. Int J Mol Sci. 2024;26(1). Kłosowska AĆ, Agnieszka; Jankowski, Maciej; Wierzba, Jolanta. DOWN SYNDROME, INCREASED RISK OF DEMENTIA AND LIPID DISTURBANCES. Developmental Period Medicine. 2017:1-5. Marfell-Jones M, Olds T, Carter S, Carter L. Estandares Internacionales para Mediciones Antropométricas. Sociedad Internacional para el Avance de la Cineantropometría. 2006. Flores Arizmendi KA, Garcia De La Puente S, Gonzalez Navarro M, Bonillo Suarez L, De Leon Becerra AG, Valderrama Hernandez A, et al. Growth charts for Mexican children with Down syndrome. Am J Med Genet A. 2022;188(4):1170-83. CDC. Percentiles niños y niñas de 2 a 20 años. Centro-Nacional-de-Estadísticas-de-Salud Centro Nacional para la Prevención de Enfermedades Crónicas y Promoción de Salud. 2000. Expert Panel on Integrated Guidelines For Cardiovascular Health and Risk Reduction in Children and Adolescents. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pedriatrics. 2022;128:S213. Vrablík M, Dobiášová M, Zlatohlávek L, Urbanová Z, Češka R. Biomarkers of cardiometabolic risk in obese/overweight children: effect of lifestyle intervention. Physiol Res. 2014;63(6):743-52. Kalla R, Adams AT, Ventham NT, Kennedy NA, White R, Clarke C, et al. Whole Blood Profiling of T-cell-Derived microRNA Allows the Development of Prognostic models in Inflammatory Bowel Disease. Journal of Crohn's and Colitis. 2020;14(12):1724-33. Seveno D, Vaillant A, Rioboo R, Adão H, Conti J, De Coninck J. Dynamics of wetting revisited. Langmuir. 2009;25(22):13034-44. QIAGEN. QIAGEN® OneStep RT-PCR Kit Handbook. QIAGEN Sample & Assay Technologies. 2012. Applied Biosystems. StepOne™ and StepOnePlus™ Real-Time PCR Systems: User Guide (v2.3). Thermo Fisher Scientific. 2019. Belbin O, Dunn JL, Ling Y, Morgan L, Chappell S, Beaumont H, et al. Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene and the rate of cognitive decline in Alzheimer's disease. Hum Mol Genet. 2007;16(18):2199-208. Adelekan T, Magge S, Shults J, Stallings V, Stettler N. Lipid profiles of children with Down syndrome compared with their sibilings. Pediatrics. 2012;129:1382-7. Krzesińska A, Kłosowska A, Sałaga-Zaleska K, Ćwiklińska A, Mickiewicz A, Chyła G, et al. Lipid Profile, Lp(a) Levels, and HDL Quality in Adolescents with Down Syndrome. J Clin Med. 2022;11(15). Pérez-Villarreal JM, Aviña-Padilla K, Beltrán-López E, Guadrón-Llanos AM, López-Bayghen E, Magaña-Gómez J, et al. Profiling of circulating chromosome 21-encoded microRNAs, miR-155, and let-7c, in down syndrome. Mol Genet Genomic Med. 2022;10(6):e1938. Shaki D, Hershkovitz E, Tamam S, Bollotin A, David O, Yalovitsky G, et al. GH treatment in pediatric Down syndrome: a systematic review and mini meta-analysis. Front Endocrinol (Lausanne). 2023;14:1135768. Cresp-Barría MC-N, Felipe; Ojeda-Nahuelcura, Rodrigo; Machuca-Barría, Claudia; Carrasco-Jiménez, Ángela. Correlación de variables antropométrica como predictor de salud, en una población de niños y adolescentes con síndrome de Down de Temuco, Chile. Rev Fac Med. 2014;62:193-8. Oreskovic NM, Baumer NT, Di Camillo C, Cornachia M, Franklin C, Hart SJ, et al. Cardiometabolic profiles in children and adults with overweight and obesity and down syndrome. Am J Med Genet A. 2023;191(3):813-22. Blanco-Montaño A, Ramos-Arenas M, Yerena-Echevarría BA, Miranda-Santizo LD, Ríos-Celis AL, Dorantes-Gómez AT, et al. [Risk factors in the origin of Down syndrome]. Rev Med Inst Mex Seguro Soc. 2023;61(5):638-44. Garcia-de la Puente S, Flores-Arizmendi KA, Delgado-Montemayor MJ, Vargas-Robledo TT. Lipid profile of Mexican children with Down syndrome. BMC Pediatr. 2021;21(1):77. Calcaterra V, Gazzarri A, De Silvestri A, Madia C, Baldassarre P, Rossi V, et al. Thyroid function, sensitivity to thyroid hormones, and metabolic syndrome in euthyroid children and adolescents with Down syndrome. J Endocrinol Invest. 2023;46(11):2319-25. Luchsinger JA, Pang D, Krinsky-McHale SJ, Schupf N, Lee JH, Silverman W, et al. Obesity, diabetes and their metabolic correlates in middle-aged adults with Down syndrome. J Intellect Disabil Res. 2024;68(3):212-22. Manfredo J, Capone G, Yanek L, McCarter R, Zemel B, Kelly A, et al. Cardiometabolic risk in young adults with Down syndrome. Am J Med Genet A. 2023;191(7):1758-68. Adelekan T, Magge S, Shults J, Stallings V, Stettler N. Lipid profiles of children with Down syndrome compared with their siblings. Pediatrics. 2012;129(6):e1382-7. Pu Q, Huang Y, Lu Y, Peng Y, Zhang J, Feng G, et al. Tissue-specific and plasma microRNA profiles could be promising biomarkers of histological classification and TNM stage in non-small cell lung cancer. Thorac Cancer. 2016;7(3):348-54. Cabiati M, Guiducci L, Randazzo E, Casieri V, Federico G, Del Ry S. Circulating and Exosomal microRNA-33 in Childhood Obesity. Biomedicines. 2023;11(8). Lemere CA, Head E, Holtzman DM. APOE epsilon4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All. JAMA Neurol. 2021;78(8):913-5. Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu C-C, et al. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids. 2019. Sinha RA, Bruinstroop E, Yen PM. Actions of thyroid hormones and thyromimetics on the liver. Nat Rev Gastroenterol Hepatol. 2025;22(1):9-22. Aversa T, Crisafulli G, Zirilli G, De Luca F, Gallizzi R, Valenzise M. Epidemiological and clinical aspects of autoimmune thyroid diseases in children with Down's syndrome. Ital J Pediatr. 2018;44(1):39. Gastelum Guerrero C, Cháidez Fernández YL, Magaña Ordorica D, Berger H, Vazquez Landrove M, Guadrón Llanos A, et al. A systematic review and meta-analysis of serum lipid concentrations in people with Down syndrome. J Intellect Disabil Res. 2024;68(6):553-63. Underwood PC, Zhang L, Mohr DC, Prentice JC, Nelson RE, Budson AE, et al. Glycated Hemoglobin A1c Time in Range and Dementia in Older Adults With Diabetes. JAMA Netw Open. 2024;7(8):e2425354. Ye J, Huang Z, Liang C, Yun Z, Huang L, Liu Y, et al. Thyroid dysfunction and risk of different types of dementia: A systematic review and meta-analysis. Medicine (Baltimore). 2024;103(34):e39394. Martínez-Hernández RM, Mónica;. MicroRNAs en enfermedades tiroideas autoinmunes y su papel como biomarcadores. Mejores prácticas e investigación endocrinología clínica y metabolismo. 2023;37. Rayner KJ, Suárez Y, Dávalos A, Parathath S, Fitzgerald ML, Tamehiro N, et al. MiR-33 contributes to the regulation of cholesterol homeostasis. 2010. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8845542","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":595545201,"identity":"e9af0167-a9f5-43f0-a55a-4d1a656c529c","order_by":0,"name":"Kenia Esparza Ocampo","email":"","orcid":"","institution":"Posgrado en Ciencias Biomédicas, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa","correspondingAuthor":false,"prefix":"","firstName":"Kenia","middleName":"Esparza","lastName":"Ocampo","suffix":""},{"id":595545202,"identity":"ebfbb20d-9c4b-48cf-93e0-3864e8b86b59","order_by":1,"name":"Wendy Gastelum 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Sinaloa","correspondingAuthor":true,"prefix":"","firstName":"Javier","middleName":"Magaña","lastName":"Gómez","suffix":""}],"badges":[],"createdAt":"2026-02-10 22:38:04","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-8845542/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8845542/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":103438934,"identity":"5e6c454e-ede9-45d8-9dc2-13ff809c9597","added_by":"auto","created_at":"2026-02-25 16:56:28","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":41907,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003ePopulation of the study\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-8845542/v1/53e9ef73e7a6603e75f124dd.png"},{"id":103438671,"identity":"5dac8f76-aa20-4ab9-904a-97f3ce9cd4f2","added_by":"auto","created_at":"2026-02-25 16:55:56","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":49633,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eExpression levels of a) miR-33a and b) miR-33b in the study groups.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003emiR-33a: miRNA-33a, miR-33b: miRNA-33b, SNORD48: small nucleolar RNA 48, CTRL: control, DS: Down syndrome.\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-8845542/v1/f86a2b27e69843edd50c0ae1.png"},{"id":103438734,"identity":"35fd24cc-4a0a-4afd-beda-eecb418836d0","added_by":"auto","created_at":"2026-02-25 16:56:06","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":48819,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eExpression of a) miR-33a and b) miR-33b by age groups in the study cohorts.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eCTRL: control, DS: Down syndrome.\u003c/p\u003e","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-8845542/v1/94b6623481fa17afe6842909.png"},{"id":103438732,"identity":"b07fea9f-c3f3-43e8-98c5-2f3ecca2913e","added_by":"auto","created_at":"2026-02-25 16:56:06","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":34288,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eGenotype and HDL-c concentration in the study groups.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eValues represent the mean concentration of the study groups. HDL-c: HDL cholesterol; CTRL: control; DS: Down syndrome; ε: apolipoprotein E epsilon.\u003c/p\u003e","description":"","filename":"4.png","url":"https://assets-eu.researchsquare.com/files/rs-8845542/v1/d128bab786fb67047eabd04a.png"},{"id":103438827,"identity":"5659d9f1-b49f-4e3b-bcd5-66d86b29dae0","added_by":"auto","created_at":"2026-02-25 16:56:15","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":45226,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eRisk allele and HDL-c in the study groups.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eData points represent HDL-c concentrations in the study groups, stratified by the presence of the \u003cem\u003eAPOE\u003c/em\u003e risk allele ε4. HDL-c: HDL cholesterol; CTRL: control; DS: Down syndrome; Risk: presence of the apolipoprotein E ε4 allele, **\u003cem\u003ep \u003c/em\u003e\u0026lt; 0.01.\u003c/p\u003e","description":"","filename":"5.png","url":"https://assets-eu.researchsquare.com/files/rs-8845542/v1/a28a3e5c7dff704e5b8f2290.png"},{"id":103438710,"identity":"d419d5e7-a556-4d11-bc68-0072bf2ffeee","added_by":"auto","created_at":"2026-02-25 16:56:05","extension":"png","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":52551,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eRisk allele and expression of miR-33a and miR-33b in the study groups.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDots represent the expression levels of miR-33a and miR-33b in the study groups, stratified by the presence of the \u003cem\u003eAPOE\u003c/em\u003e risk allele. miR-33a: miRNA-33a, miR33-b: miRNA-33b, SNORD48: small nucleolar RNA 48, CTRL: control, DS: Down syndrome, Risk: presence of the \u003cem\u003eAPOE\u003c/em\u003e risk allele ε4.\u003c/p\u003e","description":"","filename":"6.png","url":"https://assets-eu.researchsquare.com/files/rs-8845542/v1/0ee7eadf8f6d49b86b53bc6b.png"},{"id":103438983,"identity":"82122dc5-939c-41ae-adbf-f70843ff8035","added_by":"auto","created_at":"2026-02-25 16:56:41","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2560635,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8845542/v1/e29ad06a-9568-47ce-9245-b3f2409cc7a2.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Associations Among miR-33, APOE ε4, and Metabolic Markers in Down Syndrome Youth","fulltext":[{"header":"Background","content":"\u003cp\u003eDown syndrome (DS) is a genetic disorder resulting from an additional copy of chromosome 21, either partial or complete, leading to trisomy, characterized by intellectual disability and distinctive phenotypic features\u0026nbsp;(1). Its global incidence ranges from 1 in 1,000 to 1 in 1,100 live births. In 2021, the worldwide prevalence was estimated at 19.9 per 100,000 inhabitants, corresponding to approximately 1.57 million individuals living with DS (2). Advanced maternal age (\u0026gt;35 years) has been identified as a major risk factor for congenital chromosomal abnormalities, including DS (1). Over the past decades, advances in prevention, diagnosis, and management of comorbidities have markedly improved the life expectancy of individuals with DS, from about 5 years in the 1950s to nearly 60 years today (3-5).\u003c/p\u003e\n\u003cp\u003eThe characteristic phenotype of trisomy 21 reflects the consequences of genomic imbalance. Chromosome 21 sequencing and experimental models in humans, mice, and cell cultures have substantially contributed to understanding the molecular repercussions of this additional genetic material (6-8).\u003c/p\u003e\n\u003cp\u003eMicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression and are implicated in essential biological processes, including lipid metabolism and the pathophysiology of cardiovascular and neurodegenerative diseases (9). Among them, miR-33, encoded within the introns of \u003cem\u003eSREBF2\u003c/em\u003e and \u003cem\u003eSREBF1\u003c/em\u003e, modulates HDL cholesterol (HDL-c) biogenesis and excretion by regulating \u003cem\u003eABCA1\u003c/em\u003e expression as well as bile acid synthesis and secretion (9, 10). In animal models, inhibition of miR-33 elevates plasma HDL-c levels and confers protection against atherosclerosis (11).\u003c/p\u003e\n\u003cp\u003eRegulated expressions of miR-33 may therefore exert protective effects against atherosclerosis and other HDL-c related disorders, representing a potential therapeutic target (11). In individuals with DS, no direct association or specific phenotypic role of miR-33 has been reported. However, given its established role in cholesterol metabolism via \u003cem\u003eABCA1\u003c/em\u003e regulation and HDL biogenesis, mechanisms also implicated in cognitive decline linked to the \u003cem\u003eAPOE\u003c/em\u003e \u0026epsilon;4 isoform, its potential contribution in DS warrants investigation (10, 12).\u003c/p\u003e\n\u003cp\u003eEvidence from animal and human models indicates that miR-33 regulates lipid transport and oxidation pathways by interacting with genes such as \u003cem\u003eABCA1\u003c/em\u003e and \u003cem\u003eSREBP\u003c/em\u003e, thereby modulating HDL biogenesis and cholesterol flux at the tissue level. Moreover, the functional connection between miR-33 and brain lipid-regulatory systems underscores the integration of miRNA signaling with proteins such as\u003cem\u003e\u0026nbsp;APOE\u003c/em\u003e and transporters, including ABCA1, in maintaining cerebral lipid homeostasis and neuroprotection. Dysregulation of miR-33 and APOE may therefore jointly impair cholesterol metabolism and \u0026beta;-amyloid processing, offering novel therapeutic and diagnostic perspectives for neurodegenerative diseases associated with HDL-c (13, 14).\u003c/p\u003e\n\u003cp\u003ePlasma HDL-c levels and the function of lipoproteins such as \u003cem\u003eAPOE\u003c/em\u003e are essential for vascular integrity, cerebral cholesterol balance, and \u0026beta;-amyloid clearance. Variants of the APOE gene, particularly \u0026epsilon;4, have been linked to increased risk of cognitive decline and dementia, especially in individuals with DS, where they accelerate the onset of Alzheimer\u0026rsquo;s disease, like symptoms, and disrupt cerebral lipid homeostasis (15).\u003c/p\u003e\n\u003cp\u003eFunctionally, \u003cem\u003eAPOE\u003c/em\u003e regulates cerebral cholesterol metabolism, including \u0026beta;-amyloid clearance, through interactions with ABCA1 and lipoprotein receptors (16). It is also a well-established genetic determinant of neurodegenerative diseases such as Alzheimer\u0026rsquo;s, which manifests earlier in individuals with DS (17, 18). The \u0026epsilon;4 isoform has been consistently associated with an increased risk and faster progression of cognitive impairment, whereas \u0026epsilon;2 appears to confer a protective effect (17, 19). In people with DS, the \u0026epsilon;4 allele is associated with more severe, earlier-onset cognitive decline (19).\u003c/p\u003e\n\u003cp\u003eThyroid dysfunction is also markedly more prevalent among individuals with DS, occurring at significantly higher rates than in the general population, from childhood through adulthood. These disorders tend to appear earlier and have a pronounced impact on neurological development. Combined with genetic factors such as \u003cem\u003eAPOE\u0026nbsp;\u003c/em\u003e\u0026epsilon;4, thyroid dysfunction may potentiate or accelerate cognitive deterioration in this population (20).\u003c/p\u003e\n\u003cp\u003eGiven the high prevalence of dyslipidemias characterized by low HDL-c levels, frequent thyroid abnormalities, and the genetic predisposition conferred by APOE variants in DS, along with the regulatory role of miR-33 in lipid metabolism, it is essential to investigate the interactions among these factors. Their combined influence may contribute to early cognitive decline in DS (9, 17, 21). Understanding these mechanisms could help identify specific biomarkers and therapeutic targets to mitigate cognitive deterioration and cardiovascular comorbidities in this population.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eStudy design\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA cross-sectional study with a descriptive, correlational design was conducted to compare individuals with DS with healthy control participants (CTRL). Written informed consent was obtained from the parents or legal guardians of all participants. All collected data were anonymized to ensure confidentiality. The study protocol was reviewed and approved by the Ethics Committee of the Faculty of Medicine, Autonomous University of Sinaloa, with registration number CEI-FM-PI-2023-009, in accordance with current ethical standards and regulations.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStudy population\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eInitially, 91 individuals with a confirmed diagnosis of DS were recruited through an open social media call. Eligible participants included individuals with a history of thyroid disorders or prior surgical procedures. Exclusion criteria included a previous diagnosis of leukemia, incomplete clinical information, or insufficient blood sample for analysis. After applying inclusion and exclusion criteria, the final study population comprised 50 participants with cytogenetically confirmed DS, aged 3 to 18 years, of both sexes (Figure 1). Additionally, a control group of 50 healthy participants without DS or other known genetic conditions, matched by age and sex, was also enrolled.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnthropometric evaluation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBody weight and body fat percentage were measured using a digital scale (Tanita BF689, Tokyo, JP). Height was measured using a stadiometer (SECA 2013, Birmingham, UK), and waist and hip circumferences were measured using a metallic tape (Lufkin, Apex Tool Group, Sparks, MD, USA). All measurements were taken with participants barefoot and wearing light clothing, following standardized procedures established by the International Society for the Advancement of Kinanthropometry (ISAK) (22). Body mass index (BMI) was calculated as weight (kg) divided by height squared (m\u003csup\u003e2\u003c/sup\u003e). BMI in the DS group was classified using age-appropriate percentile tables from the National Institute of Pediatrics (INP): \u0026lt;5\u003csup\u003eth\u003c/sup\u003e percentile, underweight; 5\u003csup\u003eth\u003c/sup\u003e\u0026ndash;90\u003csup\u003eth\u003c/sup\u003e, healthy weight; 90\u003csup\u003eth\u003c/sup\u003e\u0026ndash;95\u003csup\u003eth\u003c/sup\u003e, overweight, and \u0026gt;95\u003csup\u003eth\u003c/sup\u003e, obesity (23). For the CTRL group, BMI-for-age percentiles were determined according to the Centers for Disease Control and Prevention (CDC): \u0026lt;5\u003csup\u003eth\u003c/sup\u003e percentile, underweight; 5\u003csup\u003eth\u003c/sup\u003e\u0026ndash;85\u003csup\u003eth\u003c/sup\u003e, healthy weight; 85\u003csup\u003eth\u003c/sup\u003e\u0026ndash;95\u003csup\u003eth\u003c/sup\u003e, overweight; and \u0026gt;95\u003csup\u003eth\u003c/sup\u003e, obesity (24).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eBiochemical evaluation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePeripheral blood was collected via venipuncture after 10-12 hours of overnight fasting into EDTA and SST tubes, centrifuged at 3500 rpm for 10 min, and stored at \u0026ndash;80\u0026deg;C until analysis. Serum concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and HDL-c were determined using an enzymatic colorimetric method (RANDOX Laboratories Ltd., Antrim, UK). Dyslipidemia was defined according to the National Cholesterol Education Program (NCEP) criteria for children and adolescents: TC \u0026ge; 200 mg/dL; TG \u0026ge; 100 mg/dL (0\u0026ndash;9 years) or \u0026ge;130 mg/dL (\u0026ge;10 years); HDL-c \u0026lt; 40 mg/dL; and LDL-c \u0026ge; 130 mg/dL (25). Atherogenic risk was estimated using the TC/HDL-c ratio and the logarithmic TG/HDL-c index (26). Glucose and glycated hemoglobin (HbA1c) were measured by enzymatic colorimetry (RANDOX Laboratories Ltd., Antrim, UK) and classified according to the American Diabetes Association (ADA) criteria: glucose \u0026ge;126 mg/dL and HbA1c \u0026ge;6.5% as thresholds for diabetes risk.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMiRNA quantification\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePlasma miRNAs were extracted using the phenol-based TRIzol reagent (Invitrogen Life Technologies) from 200 \u0026micro;L of plasma per participant. Extracted RNA was diluted in 8 \u0026micro;L of RNase-free water and stored at \u0026ndash;80\u0026deg;C. cDNA synthesis was performed with the miRCURY\u0026trade; LNA\u0026trade; RT Kit (QIAGEN Cat. No. 339340) in a 10 \u0026micro;L reaction containing 7 \u0026micro;L of purified RNA. Reaction conditions were as follows: reverse transcription at 45\u0026deg;C for 60 min, inactivation at 95\u0026deg;C for 5 min, and storage at 4\u0026deg;C. Quantification of miR-33a-5p (miR-33a) and miR-33b-3p (miR-33b) expression was performed by real-time quantitative PCR (qPCR) using the miRCURY LNA SYBR\u0026reg; Green PCR Kit (QIAGEN, Hilden, Germany), following the manufacturer\u0026rsquo;s protocol. \u003cem\u003eSNORD48\u003c/em\u003e was used as the endogenous control (12, 27). Reactions were run on a StepOnePlus\u003csup\u003eTM\u003c/sup\u003e Real-Time PCR System (Applied Biosystems) under the following conditions: 95\u0026deg;C for 2 min; 40 cycles of 95\u0026deg;C for 10 s; and melt curve stage of 95\u0026deg;C for 15 s, 60\u0026deg;C for 1 min, and a gradual temperature increase of 0.3\u0026deg;C per step, and a final denaturation at 95\u0026deg;C for 15 seconds, during which fluorescence data were continuously collected. PCR efficiencies were calculated using LinRegPCR software (28).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAPOE genotyping\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eGenomic DNA was extracted from blood leukocytes using the DNeasy Blood \u0026amp; Tissue Kit (QIAGEN, Cat. 69504, Hilden, Germany). Allelic discrimination of \u003cem\u003eAPOE\u003c/em\u003e isoforms was performed by real-time PCR using TaqMan\u0026reg; probes (29) on a StepOnePlus\u003csup\u003eTM\u003c/sup\u003e Real-Time PCR System (Applied Biosystems). The analyzed variants were rs429358 and rs7412, located in exon 4 of the APOE gene, which together determine the \u0026epsilon;2, \u0026epsilon;3, and \u0026epsilon;4 alleles. Genotype analysis was performed using TaqMan Genotyper Software (30, 31).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNormality of data distribution was assessed using the Kolmogorov\u0026ndash;Smirnov test. Continuous variables are presented as mean \u0026plusmn; standard deviation (SD). Between-group comparisons were conducted using paired or unpaired Student\u0026rsquo;s \u003cem\u003et\u003c/em\u003e-tests for parametric data, and Mann\u0026ndash;Whitney or Wilcoxon tests for nonparametric data. Categorical variables were analyzed using the chi-square test (\u0026chi;\u0026sup2;). Measures of central tendency and dispersion were calculated for all quantitative variables. Pearson or Spearman correlation coefficients were applied depending on data distribution, and multiple linear regression analyses were performed to assess associations between HDL-c and key anthropometric and biochemical parameters. Statistical analyses were conducted using GraphPad Prism 8.0 and SPSS version 25.0, with \u003cem\u003ep\u003c/em\u003e \u0026lt; 0.05 considered significant.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eStudy population\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study included 50 individuals with DS (DS group) and 50 age- and sex-matched individuals without DS (CTRL group). Sixty-two percent of the participants were male, with ages ranging from 3 to 18 years (mean age of 10.0 \u0026plusmn; 3.7 years). In the DS group, karyotype analysis revealed that 96% of participants had full trisomy 21, 2% had a translocation, and another 2% exhibited mosaicism (Table 1).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1. \u003c/strong\u003eGeneral characteristics of the study groups\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"438\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 208px;\"\u003e\n \u003cp\u003eVariable\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118px;\"\u003e\n \u003cp\u003eCTRL group\u003c/p\u003e\n \u003cp\u003en (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112px;\"\u003e\n \u003cp\u003eDS group\u003c/p\u003e\n \u003cp\u003en (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 208px;\"\u003e\n \u003cp\u003eAge (years)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118px;\"\u003e\n \u003cp\u003e10.0 \u0026plusmn; 3.7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112px;\"\u003e\n \u003cp\u003e10.0 \u0026plusmn; 3.7\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 208px;\"\u003e\n \u003cp\u003eSex\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118px;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 112px;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 208px;\"\u003e\n \u003cp\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; Male\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118px;\"\u003e\n \u003cp\u003e31 (62.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112px;\"\u003e\n \u003cp\u003e31 (62.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 208px;\"\u003e\n \u003cp\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; Female\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118px;\"\u003e\n \u003cp\u003e19 (38.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112px;\"\u003e\n \u003cp\u003e19 (38.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 208px;\"\u003e\n \u003cp\u003eKaryotype\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118px;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 112px;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 208px;\"\u003e\n \u003cp\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; Full trisomy 21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118px;\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112px;\"\u003e\n \u003cp\u003e48 (96.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 208px;\"\u003e\n \u003cp\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Translocation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118px;\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112px;\"\u003e\n \u003cp\u003e1 (2.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 208px;\"\u003e\n \u003cp\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Mosaicism\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118px;\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112px;\"\u003e\n \u003cp\u003e1 (2.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eValues are presented as mean \u0026plusmn; standard deviation (SD). CTRL: control; DS: Down syndrome.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnthropometric characteristics\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eParticipants with DS showed significantly lower mean body weight and height compared to controls (34.4 \u0026plusmn; 15.6 vs. 41.9 \u0026plusmn; 21.9 kg, \u003cem\u003ep\u003c/em\u003e = 0.0028; 125.1 \u0026plusmn; 17.7 vs. 141.0 \u0026plusmn; 20.1 cm, \u003cem\u003ep\u003c/em\u003e = 0.0001, respectively). No significant differences were observed in BMI, waist, or hip circumference between groups (Table 2).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2. Anthropometric characteristics of the study groups\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 217px;\"\u003e\u003cstrong\u003eVariable\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e\u003cstrong\u003eCTRL group\u003c/strong\u003e\u003cbr\u003eMean \u0026plusmn; SD\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e\u003cstrong\u003eDS group\u003c/strong\u003e\u003cbr\u003eMean \u0026plusmn; SD\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 104px;\"\u003e\u003cstrong\u003e\u003cem\u003ep value\u003c/em\u003e\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 217px;\"\u003e\u003cstrong\u003eWeight (kg)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e41.9 \u0026plusmn; 21.9\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e34.4 \u0026plusmn; 15.6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 104px;\"\u003e\u003cstrong\u003e0.0028\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 217px;\"\u003e\u003cstrong\u003eHeigh (cm)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e141.0 \u0026plusmn; 20.1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e125.1 \u0026plusmn; 17.7\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 104px;\"\u003e\u003cstrong\u003e0.0001\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 217px;\"\u003e\u003cstrong\u003eBMI (kg/m\u0026sup2;)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e20.8 \u0026plusmn; 5.3\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e19.7 \u0026plusmn; 6.1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 104px;\"\u003e0.1053\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 217px;\"\u003e\u003cstrong\u003eWaist (cm)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e65.8 \u0026plusmn; 13.9\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e65.0 \u0026plusmn; 15.3\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 104px;\"\u003e0.8905\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 217px;\"\u003e\u003cstrong\u003eHip (cm)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e77.4 \u0026plusmn; 17.1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e75.4 \u0026plusmn; 14.8\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 104px;\"\u003e0.2959\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 217px;\"\u003e\u003cstrong\u003e%Fat (%)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e22.8 \u0026plusmn; 9.3\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 132px;\"\u003e24.8 \u0026plusmn; 9.3\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 104px;\"\u003e0.4446\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eCTRL: control; DS: Down syndrome; BMI: body mass index; %Fat: body fat percentage. \u003cem\u003ep\u003c/em\u003e \u0026lt; 0.05 was considered statistically significant.\u003c/p\u003e\n\u003cp\u003eAlthough BMI did not differ significantly, a higher proportion of DS participants have overweight or obesity (38%) compared to controls (24%), while the proportion with a healthy weight was greater in the CTRL group (70% vs. 60%).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eBiochemical characteristics\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBiochemical analysis revealed that individuals with DS had significantly lower HDL-c concentrations than controls (47.5 \u0026plusmn; 13.3 vs. 55.5 \u0026plusmn; 13.7 mg/dL, \u003cem\u003ep\u0026nbsp;\u003c/em\u003e= 0.0047) and higher TG levels (97.6 \u0026plusmn; 38.4 vs. 75.9 \u0026plusmn; 36.0 mg/dL, \u003cem\u003ep = 0.0139\u003c/em\u003e). TC did not differ significantly; however, the TC/HDL-c ratio was higher in the DS group (3.6 \u0026plusmn; 2.2 vs. 2.9 \u0026plusmn; 0.6, \u003cem\u003ep\u003c/em\u003e = 0.0181).\u003c/p\u003e\n\u003cp\u003eThe plasma atherogenic index (PAI) was also elevated in DS (\u003cem\u003ep\u003c/em\u003e = 0.0007), suggesting increased cardiovascular risk. Thyroid function parameters (TSH, free and total T4, total T3) showed significant differences between groups (Table 3).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 3. Biochemical concentrations in the study groups\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eVariable\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e\u003cstrong\u003eCTRL group\u003c/strong\u003e\u003cbr\u003eMean \u0026plusmn; SD\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e\u003cstrong\u003eDS group\u003c/strong\u003e\u003cbr\u003eMean \u0026plusmn; SD\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e\u003cem\u003ep value\u003c/em\u003e\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eTC (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e160.0 \u0026plusmn; 32.4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e155.8 \u0026plusmn; 31.4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e0.5369\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eTG (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e75.9 \u0026plusmn; 36.0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e97.6 \u0026plusmn; 38.4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0139\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eHDL-c (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e55.5 \u0026plusmn; 13.7\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e47.3 \u0026plusmn; 13.3\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0047\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eLDL-c (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e89.2 \u0026plusmn; 21.5\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e88.8 \u0026plusmn; 26.9\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e0.9391\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eVLDL-c (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e14.6 \u0026plusmn; 6.3\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e19.9 \u0026plusmn; 8.6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0035\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eTC/HDL-c\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e2.9 \u0026plusmn; 0.6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e3.6 \u0026plusmn; 2.2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0181\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eIAP [Log(TG/HDL-c)]\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e0.1 \u0026plusmn; 0.2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e0.2 \u0026plusmn; 0.2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0007\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eGlucose (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e92.1 \u0026plusmn; 14.8\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e92.6 \u0026plusmn; 7.7\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e0.4850\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eHbA1c (%)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e5.1 \u0026plusmn; 0.3\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e5.1 \u0026plusmn; 0.4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e0.6431\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eUric acid (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e3.9 \u0026plusmn; 1.1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e5.2 \u0026plusmn; 0.9\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0001\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eUrea (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e21.1 \u0026plusmn; 7.1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e27.9 \u0026plusmn; 6.7\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0001\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eCreatinine (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e0.4 \u0026plusmn; 0.1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e0.5 \u0026plusmn; 0.1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0068\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eTSH (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e2.4 \u0026plusmn; 1.5\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e3.8 \u0026plusmn; 2.3\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.001\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eFree T4 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e1.1 \u0026plusmn; 0.1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e1.2 \u0026plusmn; 0.2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0134\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eTotal T4 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e7.7 \u0026plusmn; 1.6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e8.7 \u0026plusmn; 2.0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0043\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eFree T3 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e4.6 \u0026plusmn; 1.0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e4.8 \u0026plusmn; 0.7\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e0.3699\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003eTotal T3 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e142.8 \u0026plusmn; 30.6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e122.8 \u0026plusmn; 26.5\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0036\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003emiR-33a\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e1.5 \u0026plusmn; 1.2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e0.9 \u0026plusmn; 1.9\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e\u003cstrong\u003e0.0047\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 203px;\"\u003e\u003cstrong\u003emiR-33b\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 147px;\"\u003e1.6 \u0026plusmn; 1.4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 183px;\"\u003e133.4 \u0026plusmn; 727.0 (0.6 \u0026plusmn; 1.6)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 83px;\"\u003e0.5043\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eCTRL: control; DS: Down syndrome; TC: total cholesterol; TG: Triglycerides; HDL-c: HDL cholesterol; LDL-c: LDL cholesterol; VLDL-c: VLDL cholesterol; IAP: plasma atherogenic index; HbA1c: glycated hemoglobin; TSH: thyroid-stimulating hormone; T4: thyroxine; T3: triiodothyronine; IAP: plasma atherogenic index. \u003cem\u003ep\u003c/em\u003e \u0026lt; 0.05 was considered statistically significant.\u003c/p\u003e\n\u003cp\u003eThe DS group showed a greater frequency of dyslipidemias (hypertriglyceridemia, low HDL-c, and high LDL-c) and thyroid dysfunction compared to controls, although not all reached statistical significance. The atherogenic risk was significantly higher in DS (\u003cem\u003ep\u003c/em\u003e = 0.0001), with 66% classified as high risk versus 30% in the CTRL group (Table 4).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 4. Categorical classification of variables of interest\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"614\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u003cstrong\u003eVariable\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e\u003cstrong\u003eCTRL (n=50)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e\u003cstrong\u003eDS (n=50)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e\u003cem\u003ep value\u003c/em\u003e\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" valign=\"top\" style=\"width: 538px;\"\u003e\u003cstrong\u003eBMI\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e0.0156\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Underweight (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Normal weight (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e70\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e60\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Overweight/Obesity (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e24\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e38\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" valign=\"top\" style=\"width: 538px;\"\u003e\u003cstrong\u003eDyslipidemias\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e0.0631\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Hypercholesterolemia (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e12\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e10\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Hypertriglyceridemia (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e14\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e28\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Low HDL-c (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e12\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e24\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;High LDL-c (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e8\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" valign=\"top\" style=\"width: 538px;\"\u003e\u003cstrong\u003eThyroid disorders (%)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e0.0001\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Hypothyroidism (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e48\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Hyperthyroidism (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Low/High TSH (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e34\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Low/High free T4 (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Low/High total T4 (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Low/High free T3 (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e73\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e58\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Low/High total T3 (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e16\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" valign=\"top\" style=\"width: 538px;\"\u003e\u003cstrong\u003eAtherogeneity\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e0.0001\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Low risk (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e52\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e22\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Medium risk (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e16\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e12\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 245px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;High risk (%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e30\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 142px;\"\u003e66\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eThe values represent percentages (%). CTRL: control, DS: Down syndrome, BMI: Body mass index, HDL-c: HDL cholesterol, LDL-c: LDL cholesterol, TSH: thyroid-stimulating hormone, T4: thyroxine, T3: triiodothyronine. \u003cem\u003ep\u003c/em\u003e \u0026lt; 0.05 was considered significant.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eExpression levels of miR-33a and miR-33b\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eExpression of both miR-33a and miR-33b was significantly lower in the DS group compared with controls (\u003cem\u003ep\u003c/em\u003e \u0026lt; 0.0001 for boths). (Figure 1a). Median relative expression was 0.044 vs. 1.077 for for miR-33a and 0.145 vs. 1.322 for miR-33b (Figure 2a and 2b).\u003c/p\u003e\n\u003cp\u003eAge-stratified analysis (3\u0026ndash;11 and 12\u0026ndash;18 years) confirmed these trends. In both age groups, miR-33a expression remained lower in DS. For miR-33b, expression was also reduced in younger DS participants (Figure 3a) but showed a relative increase in the 12\u0026ndash;18 years subgroup (Figure 3b).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAPOE genotyping\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAPOE genotyping was performed in 30 DS and 40 CTRL samples. The \u0026epsilon;3/\u0026epsilon;3 genotype was the most frequent (DS: 73.6%; CTRL: 67.5%). The \u0026epsilon;4/\u0026epsilon;4 genotype was rare (2.6% in both groups). The \u0026epsilon;4 allele frequency was similar (DS: 11.8%, CTRL: 12.5%) (Table 5).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 5. APOE genotypic and allelic frequencies\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"601\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" valign=\"top\" style=\"width: 312px;\"\u003e\u003cstrong\u003eGenotype frequency\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"5\" valign=\"top\" style=\"width: 290px;\"\u003e\u003cstrong\u003eAllele frequency\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 94px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"top\" style=\"width: 104px;\"\u003e\u003cstrong\u003eCTRL\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"top\" style=\"width: 113px;\"\u003e\u003cstrong\u003eDS\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 63px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"top\" style=\"width: 113px;\"\u003e\u003cstrong\u003eCTRL\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"top\" style=\"width: 113px;\"\u003e\u003cstrong\u003eDS\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 94px;\"\u003e\u003cstrong\u003eGenotype\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e\u003cstrong\u003en\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u003cstrong\u003en\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 63px;\"\u003e\u003cstrong\u003eAllele\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u003cstrong\u003en\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u003cstrong\u003en\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 94px;\"\u003e\u0026epsilon;2/\u0026epsilon;2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e0.0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e2.6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 63px;\"\u003e\u0026epsilon;2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e5.0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e5\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e6.6\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 94px;\"\u003e\u0026epsilon;2/\u0026epsilon;3\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e10.0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e2.6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 63px;\"\u003e\u0026epsilon;3\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e66\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e82.5\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e62\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e81.6\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 94px;\"\u003e\u0026epsilon;2/\u0026epsilon;4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e2\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e5.6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 63px;\"\u003e\u0026epsilon;4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e10\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e12.5\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e9\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e11.8\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 94px;\"\u003e\u0026epsilon;3/\u0026epsilon;3\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e27\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e67.5\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e28\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e73.6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 63px;\"\u003e\u003cstrong\u003eTotal\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e80\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e100\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e76\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e100\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 94px;\"\u003e\u0026epsilon;3/\u0026epsilon;4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e8\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e20.0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e5\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e13.0\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 63px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 94px;\"\u003e\u0026epsilon;4/\u0026epsilon;4\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e2.5\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e2.6\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 63px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 94px;\"\u003e\u003cstrong\u003eTotal\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 47px;\"\u003e40\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e100\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e38\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e100\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 63px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 57px;\"\u003e\u0026nbsp;\u003cbr\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eThe values represent the number of individuals with each genotype, the total number of alleles (n), and the percentage (%). CTRL: control, DS: Down syndrome, \u003cem\u003eAPOE\u003c/em\u003e: apolipoprotein E.\u003c/p\u003e\n\u003cp\u003eIn carriers of the \u0026epsilon;4/\u0026epsilon;4 genotype, HDL-c concentrations were lower in DS (43.0 mg/dL) than in controls (63.5 mg/dL, \u003cem\u003ep\u003c/em\u003e = 0.0002) (Figure 4). When grouped by \u0026epsilon;4 allele carriage, the mean HDL-c was lower in the at-risk DS subgroup (41.1 mg/dL) compared to the non-risk subgroup (48.4 mg/dL). In contrast, controls carrying \u0026epsilon;4 showed higher HDL-c (61.0 mg/dL) than non-carriers (50.7 mg/dL) (Figure 5).\u003c/p\u003e\n\u003cp\u003emiR-33a and miR-33b expression were also influenced by \u003cem\u003eAPOE\u003c/em\u003e genotype. DS individuals carrying the \u0026epsilon;4 risk allele exhibited higher expression of miR-33a (1.567 vs. 0.701) and miR-33b (2.170 vs. 0.585) than non-carriers. These differences were less pronounced in controls (Figure 6b).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCorrelation of variables of interest\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn the DS group, free T3 was positively correlated with body fat percentage (r = 0.580, \u003cem\u003ep\u003c/em\u003e = 0.002), while total T4 was negatively correlated with HDL-c (r = \u0026ndash;0.331, \u003cem\u003ep\u003c/em\u003e = 0.021). HbA1c correlated negatively with TC (r = \u0026ndash;0.280, \u003cem\u003ep\u003c/em\u003e = 0.049) and positively with HDL-c (r = 0.405, \u003cem\u003ep\u003c/em\u003e = 0.004) and creatinine (r = 0.479, \u003cem\u003ep\u003c/em\u003e \u0026lt; 0.001). miR-33a correlated positively with TSH (r = 0.318, \u003cem\u003ep\u003c/em\u003e = 0.036), and negatively with free T3 (r = \u0026ndash;0.349, \u003cem\u003ep\u003c/em\u003e = 0.040). miR-33b correlated positively with TC (r = 0.298, \u003cem\u003ep\u003c/em\u003e = 0.040) and negatively with waist circumference (r = \u0026ndash;0.348, \u003cem\u003ep\u003c/em\u003e = 0.040) (Table 6).\u003c/p\u003e\n\u003cp\u003eIn contrast, in controls, total T3 and free T4 correlated negatively with TC (r = \u0026ndash;0.341, \u003cem\u003ep\u003c/em\u003e = 0.016; r = \u0026ndash;0.318, \u003cem\u003ep\u003c/em\u003e = 0.026, respectively). HbA1c showed negative correlations with HDL-c (r = \u0026ndash;0.372, \u003cem\u003ep\u003c/em\u003e = 0.009) and total T4 (r = \u0026ndash;0.382, \u003cem\u003ep\u003c/em\u003e = 0.007), and a positive correlation with the atherogenic index (r = 0.341, \u003cem\u003ep\u003c/em\u003e = 0.016) (Table 7).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 6. Correlation analysis between anthropometric and biochemical variables and miR-33 in the DS group.\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"100%\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 11px;\"\u003e\u003cstrong\u003eVariable\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e3\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e4\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e5\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e9\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e11\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e12\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e13\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e14\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e15\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e16\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e17\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e18\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e19\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e20\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e21\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cstrong\u003e22\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eAge (years)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eHeight (cm)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.928**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e3\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eWeight (kg)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.901**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.882**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e4\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003e%Fat (%)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.145\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.168\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.356\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.452\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.383\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.058\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e5\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eWaist (cm)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.644**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.612**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.720**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.315\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.096\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eHip (cm)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.839**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.815**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.969**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.502**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.743**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.006\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eCT (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.154\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.155\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.082\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.241\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.052\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.106\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.284\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.284\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.573\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.207\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.723\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.467\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eTG (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.155\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.128\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.214\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.316\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.236\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.204\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.537**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.281\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.376\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.135\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.095\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.102\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.159\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n 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style=\"width: 3px;\"\u003e0.047\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.207\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.245\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.421\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.230\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.468\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.487\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.818\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.747\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.150\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.086\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n 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style=\"width: 3px;\"\u003e.901**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.452**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.176\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n 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3px;\"\u003e0.221\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n 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3px;\"\u003e0.104\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.259\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.048\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.795\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.864\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.834\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.712\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.378\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.694\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.378\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.471\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.069\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.740\u003cbr\u003e\u003c/td\u003e\n 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rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e12\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eAtherogenic risk\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.096\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.076\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.031\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.271\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.141\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.016\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.150\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.213\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.160\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.191\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.760**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.509\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.602\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.829\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.155\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.334\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.911\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.300\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.137\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.269\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.183\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e13\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eTSH (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-.300*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.240\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.256\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.039\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.180\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.223\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.065\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.008\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.064\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.018\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.082\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.158\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.043\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.109\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.086\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.844\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.238\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.141\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.667\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.956\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.675\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.907\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.587\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.296\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e14\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eFree T3 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.036\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.148\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.218\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.580**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.017\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.230\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.148\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.002\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.284\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.020\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.295\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.061\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.146\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.835\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.391\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.201\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.002\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.923\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.183\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.389\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.992\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.094\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.906\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.081\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.724\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.394\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e15\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eTotal T3 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.329\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.236\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.300\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.148\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.254\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.271\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.240\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.172\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.159\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.224\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.003\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.102\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.066\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.593**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.050\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.166\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.076\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.462\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.141\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.115\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.158\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.316\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.353\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.189\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.985\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.555\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.704\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e16\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eFree T4 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.088\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.174\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.084\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.080\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.005\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.112\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.019\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.128\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.146\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.072\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.040\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.020\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.040\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-.341*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.086\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.546\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.232\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.566\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.685\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.971\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.450\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.897\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.382\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.318\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.625\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.785\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.892\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.791\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.042\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.619\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e17\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eTotal T4 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.067\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.067\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.064\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.047\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.022\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.078\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.093\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.198\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-.331*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.200\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.021\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.081\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.072\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.076\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.083\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.621**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.650\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.649\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.666\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.815\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.884\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.601\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.530\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.176\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.021\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.174\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.889\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.583\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.636\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.659\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.631\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e18\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eCreatinine (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.801**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.752**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.757**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.194\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.456**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.722**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.138\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.148\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.169\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.278\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.106\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.175\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.248\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.180\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.207\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.204\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.186\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.312\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.001\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.340\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.306\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.240\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.050\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.464\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.223\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.097\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.293\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.227\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.159\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.206\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e19\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eUrea (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.015\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.002\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.005\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.119\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.150\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.017\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.004\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.099\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.156\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.064\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.021\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.141\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.097\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.032\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.199\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.030\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.086\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.028\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.917\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.992\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.970\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.539\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.303\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.908\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.981\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.496\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.280\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.657\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.883\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.327\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.519\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.855\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.245\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.837\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.563\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.846\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e20\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eUric acid (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.506**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.469**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.576**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.016\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.391**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.511**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.057\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.224\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.111\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.183\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.211\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.173\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.256\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.036\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.264\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.027\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.027\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.591**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.106\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.001\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.934\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.008\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.706\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.134\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.462\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.223\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.159\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.250\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.098\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.834\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.120\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.858\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.860\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.483\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e21\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003eHbA1c (%)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.521**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.505**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.515**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.172\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.487**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.480**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-.280*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.244\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.405**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.454**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.072\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.074\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.136\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.114\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.171\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.123\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.167\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.479**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.306*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.411**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.372\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.049\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.087\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.004\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.001\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.618\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.609\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.367\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.510\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.319\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.400\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.256\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.031\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.005\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e22\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003emiR-33a\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.172\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.176\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.220\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.267\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.197\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.239\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.098\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.251\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.259\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.069\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.024\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.215\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.318*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-.349*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.215\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.175\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.108\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.146\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.139\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.139\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.111\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.243\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.231\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.132\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.170\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.184\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.106\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.506\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.085\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.076\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.641\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.874\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.142\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.036\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.040\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.216\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.238\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.473\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.323\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.345\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.369\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.452\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e23\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 9px;\"\u003e\u003cstrong\u003emiR-33b\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.139\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.184\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.227\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.349\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-.348*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.265\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e.298*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.109\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.060\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.346*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.113\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.210\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.056\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.097\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.112\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.036\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.001\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.050\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.144\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.050\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e-0.078\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.137\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.347\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.211\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.120\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.068\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.017\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.071\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.040\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.462\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.684\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.016\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.444\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.152\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.717\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.581\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.523\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.813\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.993\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.734\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.328\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.744\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.598\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e0.364\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eThe values represent the correlation coefficient (r). %Fat: body fat percentage; TC: total cholesterol; TG: Triglycerides; HDL-c: HDL cholesterol; LDL-c: LDL cholesterol; TC-HDL-c: total cholesterol/HDL cholesterol ratio; TSH: thyroid-stimulating hormone; T4: thyroxine; T3: triiodothyronine; HbA1c: glycated hemoglobin A1c; miR-33a: miRNA-33a; miR-33b: miRNA-33b. *\u003cem\u003ep\u003c/em\u003e \u0026lt; 0.05, **\u003cem\u003ep\u003c/em\u003e \u0026lt; 0.01.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 7. Correlation analysis between anthropometric and biochemical variables and miR-33 in the CTRL group.\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"100%\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 7px;\"\u003e\u003cstrong\u003eVariable\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e3\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e4\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e5\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e9\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e11\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e12\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e13\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e14\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e15\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e16\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e17\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e18\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e19\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e20\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e21\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u003cstrong\u003e22\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eAge (years)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eHeight (cm)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.923**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e3\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eWeight (kg)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.781**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.881**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e4\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003e%Fat (%)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.100\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.018\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.428**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.498\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.903\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.002\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e5\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eWaist (cm)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.596**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.557**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.734**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.720**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eHip (cm)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.789**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.765**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.708**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.523**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.814**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eCT (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.022\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.038\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.052\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.053\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.061\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.031\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.880\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.801\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.726\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.719\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.679\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.833\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eTG (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.188\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.139\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.278\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.488**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.249\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.234\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.531**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.196\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.351\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.056\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.088\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.110\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n 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style=\"width: 4px;\"\u003e-0.175\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.666**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.059\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.438\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.768\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.296\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.139\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.142\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.234\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.688\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n 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style=\"width: 4px;\"\u003e.905**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.428**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.346*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.696\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.734\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.438\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.511\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.845\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.992\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.002\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.015\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n 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4px;\"\u003e.531**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.519**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.547**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.133\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.359\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.022\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.004\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.030\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.050\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.069\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n 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4px;\"\u003e-.394**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.211\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.705**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.147\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.364\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.029\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.012\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.041\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.268\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.005\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.146\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1.551\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e13\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eTSH (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.505**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.522**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.435**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.013\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.272\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.435**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.023\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.024\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.003\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.022\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.052\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.004\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n 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4px;\"\u003e0.978\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e14\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eFree T3 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.440**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.413**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.133\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.152\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.127\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.291*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.341*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.169\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.282*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.278\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.019\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.005\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.137\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.002\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.004\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.369\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.303\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.389\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.045\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.016\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.247\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.050\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.053\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.898\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.974\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.347\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e15\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eTotal T3 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.576**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.535**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.176\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.007\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.244\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.508**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.194\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.064\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.191\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.150\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.014\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.039\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.175\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.662**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.231\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.960\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.095\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.182\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.660\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.190\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.304\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.923\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.789\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.228\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e16\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eFree T4 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.021\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.059\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.005\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.075\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.015\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.032\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.318*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.192\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.129\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.332*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.244\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.145\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.078\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.207\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.139\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.884\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.694\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.973\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.614\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.918\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.830\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.026\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.187\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.376\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.020\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.092\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.320\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.592\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.153\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.342\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e17\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eTotal T4 (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.289*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.295*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.044\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.317*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.163\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.192\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.193\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.124\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.145\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.126\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.111\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.314*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.457**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.265\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.537**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.044\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.044\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.766\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.028\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.269\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.998\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.186\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.183\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.398\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.319\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.388\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.447\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.028\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.001\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.065\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n 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4px;\"\u003e.775**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.558**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.066\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.398**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.572**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.371**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.230\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.193\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.360*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.204\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.146\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.254\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.405**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.523**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.069\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.139\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.656\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.005\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.009\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.112\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.184\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.011\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.160\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.316\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.078\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.004\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.638\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.342\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e19\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eUrea (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.065\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.021\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.150\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.205\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.103\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.128\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.213\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.001\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.149\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.226\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.031\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.081\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.166\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.196\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.232\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.082\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.195\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.246\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.655\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.888\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.309\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.162\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.486\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.388\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.141\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.997\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.307\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.118\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.832\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.578\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.254\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.176\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.109\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.578\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.179\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.088\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e20\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eUric acid (mg/dL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.413**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.507**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.564**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.231\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.571**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.485**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.117\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.187\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.043\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.086\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.152\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.195\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.148\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.004\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.252\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.136\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.065\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.697**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.191\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.003\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.114\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.000\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.424\u003cbr\u003e\u003c/td\u003e\n 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4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e21\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003eHbA1c (%)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.036\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.004\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.054\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.017\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.072\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.029\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.227\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.300*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.049\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.273\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.372**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e.341*\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.151\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.001\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.165\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.212\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-.382**\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.016\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.115\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.048\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e1\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.805\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.979\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.715\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.908\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.625\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.846\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.116\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.036\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.740\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.057\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.009\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.016\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.299\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.995\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.257\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.143\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.007\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.916\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.432\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.745\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e22\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003emiR-33a\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.075\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.199\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.217\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.014\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.040\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.047\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.007\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.024\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.125\u003cbr\u003e\u003c/td\u003e\n 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style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.694\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.309\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.259\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.941\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.836\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.807\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.971\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.898\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.510\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.507\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.780\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.680\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.376\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.747\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.831\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.842\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.648\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.990\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.285\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.745\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.328\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 2px;\"\u003e\u003cstrong\u003e23\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 5px;\"\u003e\u003cstrong\u003emiR-33b\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003er\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.001\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.130\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.252\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.029\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.172\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.120\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.062\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.038\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.151\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.122\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.208\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.106\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.234\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.014\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.292\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.048\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.038\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.275\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.063\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.236\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.167\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e-0.221\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 3px;\"\u003e\u003cem\u003ep\u003c/em\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.994\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.511\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.187\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.883\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.372\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.535\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.746\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.842\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.425\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.522\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.271\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.576\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.214\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.940\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.117\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.800\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.843\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.141\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.741\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.210\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.369\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 4px;\"\u003e0.349\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eThe values represent the correlation coefficient (r). %Fat: body fat percentage; TC: total cholesterol; TG: Triglycerides; HDL-c: HDL cholesterol; LDL-c: LDL cholesterol; TC-HDL-c: total cholesterol/HDL cholesterol ratio; TSH: thyroid-stimulating hormone; T4: thyroxine; T3: triiodothyronine; HbA1c: glycated hemoglobin A1c; miR-33a: miRNA-33a; miR33-b: miRNA-33b. *\u003cem\u003ep\u0026nbsp;\u003c/em\u003e\u0026lt; 0.05, **\u003cem\u003ep\u003c/em\u003e \u0026lt; 0.01.\u003cem\u003e\u003cbr\u003e\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMultiple linear regression\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn the DS group, multiple regression analysis identified HbA1c as a positive predictor of HDL-c (\u0026beta; = 13.25; 95% CI: 2.53 to 23.9; \u003cem\u003ep\u003c/em\u003e = 0.017), whereas total T4 was negatively associated with HDL-c (\u0026beta; = \u0026ndash;2.47; 95% CI: \u0026ndash;4.92 to \u0026ndash;0.02;\u003cem\u003e\u0026nbsp;p\u003c/em\u003e = 0.048). No other variables showed significant associations. In the CTRL group, none of the analyzed variables were significantly associated with HDL-c (Table 8).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 8. Results of multiple linear regression between HDL-c and metabolic variables\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"589\" class=\"fr-table-selection-hover\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 123px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"top\" style=\"width: 227px;\"\u003e\u003cstrong\u003eHDL-c (CTRL)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"top\" style=\"width: 239px;\"\u003e\u003cstrong\u003eHDL-c (DS)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 123px;\"\u003e\u0026nbsp;\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e\u003cstrong\u003e\u0026beta; (IC 95%)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\u003cstrong\u003e\u003cem\u003ep value\u003c/em\u003e\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e\u003cstrong\u003e\u0026beta; (IC 95%)\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 88px;\"\u003e\u003cstrong\u003e\u003cem\u003ep value\u003c/em\u003e\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 123px;\"\u003e\u003cstrong\u003eHbA1c\u0026nbsp;\u003c/strong\u003e(%)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e-2.39 (-16.57 to 11.77)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e0.735\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e13.25 (2.53 to 23.9)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 88px;\"\u003e\u003cstrong\u003e0.017\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 123px;\"\u003e\u003cstrong\u003eTSH\u0026nbsp;\u003c/strong\u003e(mg/dL)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e0.217 (-2.60 to 3.04)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e0.877\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e1.81 (-0.25 to 3.88)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 88px;\"\u003e0.084\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 123px;\"\u003e\u003cstrong\u003eFree T4\u0026nbsp;\u003c/strong\u003e(mg/dL)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e-10.69 (-48.29 to 26.90)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e0.569\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e8.28 (-12.06 to 28.64)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 88px;\"\u003e0.412\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 123px;\"\u003e\u003cstrong\u003eTotal T4\u0026nbsp;\u003c/strong\u003e(mg/dL)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e0.22 (-3.25 to 3.71)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e0.896\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e-2.47 (-4.92 to -0.02)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 88px;\"\u003e\u003cstrong\u003e0.048\u003c/strong\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 123px;\"\u003e\u003cstrong\u003eFree T3\u003c/strong\u003e (mg/dL)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e-3.96 (-10.02 to 2.10)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e0.194\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e3.49 (-4.15 to 11.14)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 88px;\"\u003e0.358\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 123px;\"\u003e\u003cstrong\u003eTotal T3\u003c/strong\u003e (mg/dL)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e0.01 (-0.19 to 0.19)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e0.967\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 151px;\"\u003e0.09 (-0.11 to 0.29)\u003cbr\u003e\u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 88px;\"\u003e0.366\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eDependent variable: HDL-c. Values represent the regression coefficient (\u0026beta;), 95% confidence intervals (95% CI), and P-values. HDL-c: high-density lipoprotein cholesterol, HbA1c: glycated hemoglobin, TSH: thyroid-stimulating hormone, T4: thyroxine, T3: triiodothyronine.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eIn this study, we quantified miR-33a and miR-33b expression, HDL-c concentrations, and the frequency of the \u003cem\u003eAPOE\u003c/em\u003e ε4 genotype in children and adolescents with DS compared with control subjects. The results showed significantly lower expression of both miRNAs in the DS group, accompanied by an unfavorable lipid profile.\u003c/p\u003e\n\u003cp\u003eIndividuals with DS had markedly lower mean body weight and height compared with controls (34.4 ± 15.6 kg and 125.1 ± 17.7 cm vs. 40.9 ± 21.9 kg and 141.0 ± 20.1 cm, respectively). This pattern is attributed to hypothalamic–pituitary axis dysfunctions and reduced growth hormone levels (32-35). A higher prevalence of overweight and obesity was observed in DS (38%) compared with controls (25%), consistent with previous reports describing frequent excess weight and its association with metabolic alterations in this population (36, 37).\u003c/p\u003e\n\u003cp\u003eThis relationship has been partially explained by the interplay of genetic, hormonal, and behavioral factors that predispose individuals with DS to increased adiposity and dyslipidemia (38). Nevertheless, prevalence estimates vary widely among studies. For instance, one study reported only 15% of participants with DS had overweight or obesity, yet identified a significant association between BMI and triglyceride concentrations (39). This supports the notion that even moderate increases in adiposity contribute substantially to dyslipidemia in DS.\u003c/p\u003e\n\u003cp\u003eRegarding thyroid function and metabolic alterations, our findings align with recent evidence showing higher rates of thyroid dysfunction and metabolic abnormalities in pediatric DS populations (40). DS participants in our study exhibited significantly higher TSH, total and free T4, and total T3 concentrations than controls, suggesting both central and peripheral dysregulation of thyroid function (20). These alterations may contribute to increased susceptibility to metabolic syndrome and disruptions in glucose and lipid metabolism (41).\u003c/p\u003e\n\u003cp\u003eAn adverse lipid profile was observed in DS, characterized by lower HDL-c levels and higher TG concentrations, findings consistent with previous studies in DS, including comparisons with unaffected siblings (33, 42, 43). The elevated atherogenic index observed here underscores a higher cardiovascular risk in this group.\u003c/p\u003e\n\u003cp\u003eAltered lipid metabolism may be modulated by dysregulation of miR-33a and miR-33b, known regulators of cholesterol efflux and HDL formation (11). Interestingly, the decreased expression of miR-33 observed in our DS cohort contrasts with studies reporting miR-33 overexpression in dyslipidemic models (11, 14). This discrepancy may stem from methodological differences, particularly the biological matrix analyzed (plasma vs. tissues), as miRNA expression can vary markedly across sample types (44). Subject age and specific genetic and metabolic features of pediatric DS populations, including obesity, may also influence miR-33 expression (45).\u003c/p\u003e\n\u003cp\u003eUnlike previous work examining other miRNAs such as miR-155 and let-7c Pérez-Villarreal, Aviña-Padilla (34), we did not identify significant correlations between miR-33 levels and other measured parameters in controls. The younger age of our participants (3–18 years) may partially explain this difference, suggesting that miR-33 expression could increase with age (34). Overall, these findings indicate that miR-33 regulation is dynamic during development, warranting further investigation to elucidate its role in DS pathophysiology.\u003c/p\u003e\n\u003cp\u003eThe presence of the \u003cem\u003eAPOE\u003c/em\u003e ε4 allele, an established risk factor for Alzheimer’s disease, was associated with lower HDL-c levels in DS, despite similar allele frequencies between groups. This suggests that the impact of ε4 on lipid metabolism may be modulated by the DS genetic background (46). Specifically, DS individuals carrying the ε4/ε4 genotype exhibited markedly lower HDL-c levels than controls with the same genotype (41.1 vs. 61.0 mg/dL, \u003cem\u003ep\u003c/em\u003e = 0.0002). This reinforces the hypothesis that gene-environment interactions in DS amplify metabolic and neurological vulnerability (46, 47).\u003c/p\u003e\n\u003cp\u003eThyroid hormones may modulate the relationship between lipid metabolism and neurodegenerative processes in DS. The positive correlation between free T3 and body fat percentage, and the inverse correlation between total T4 and HDL-c, suggest altered enzymatic regulation within the T3/T4 axis (48). These changes could impair HDL-mediated cholesterol transport, including eflux from brain tissue, potentially compromising neuronal lipid homeostasis.\u003c/p\u003e\n\u003cp\u003eGiven that individuals with DS are prone to autoimmune thyroid dysfunction and early neurodegeneration, thyroid dysregulation may intensify chronic inflammation and disrupt central cholesterol balance. Reduced HDL-c concentrations could impair \u003cem\u003eAPOE\u003c/em\u003e-mediated lipid transport and clearance, thereby heightening neurodegenerative risk (49). Collectively, these mechanisms highlight a complex interplay between thyroid dysfunction, lipid imbalance, and neuronal vulnerability in DS. Understanding these interactions could guide preventive interventions targeting metabolic pathways before irreversible neurodegenerative changes occur.\u003c/p\u003e\n\u003cp\u003eRegression analysis revealed interactions between glycemic and thyroid axes: HbA1c was positively associated with HDL-c (β = 13.25; \u003cem\u003ep\u003c/em\u003e = 0.017), while total T4 was negatively associated (β = -2.47; \u003cem\u003ep\u003c/em\u003e = 0.048). These results suggest that better glycemic control may enhance HDL-c concentrations and offer neuroprotective benefits, whereas thyroid alterations characteristic of DS could contribute to HDL-c depletion and increased Alzheimer’s risk.\u003c/p\u003e\n\u003cp\u003eInterestingly, HbA1c correlated negatively with TC but positively with HDL-c in DS, in contrast with the atherogenic pattern typically observed in the general population (50). This atypical metabolic phenotype may reflect DS-specific compensatory mechanisms, altered insulin signaling, or distinctive regulation of reverse cholesterol transport.\u003c/p\u003e\n\u003cp\u003eRecent studies support this interpretation, showing that stable HbA1c levels are associated with reduced dementia risk, whereas hyperthyroidism increases susceptibility to Alzheimer’s disease (51, 52).\u003c/p\u003e\n\u003cp\u003eAlthough similar HbA1c-lipid relationships have been reported in DS (41), our findings provide stronger statistical evidence for this association.\u003c/p\u003e\n\u003cp\u003eThe positive correlation between miR-33a and TSH, and its negative correlation with free T3, suggest potential thyroid regulation activity of miR-33a in DS. Although several miRNAs are expressed in thyroid tissue (53), no prior studies have reported such association for miR-33. These findings raise the possibility that miR-33a modulates thyroid-axis-mediated metabolic responses, potentially by regulating genes involved in lipid metabolism (54).\u003c/p\u003e\n\u003cp\u003eThe positive correlation between miR-33a and TC, together with its negative correlation with waist circumference, further supports a potential role in adipose redistribution and lipid regulation. Experimental studies in murine DS model have demonstrated tissue-dependent miR-33 expression, with elevated levels in muscle, adipose, and hepatic tissues compared to controls, where expression predominates in adipose tissue (14). Collectively, these findings support the hypothesis that miR-33a may serve as a molecular mediator linking thyroid function, lipid regulation, and body composition in DS.\u003c/p\u003e\n\u003cp\u003eWhile associations between thyroid hormones and lipids observed in controls reflect typical physiological regulation, in DS these relationships extend to anthropometric and miRNA variables, underscoring a more complex metabolic network. A recent study reported differences in thyroid hormone sensitivity and its associations with metabolic parameters in euthyroid DS children and adolescents compared with controls (40).\u003c/p\u003e\n\u003cp\u003eTo our knowledge, this is the first study to simultaneously evaluate miR-33 expression and \u003cem\u003eAPOE\u003c/em\u003e genotyping in relation to HDL-c and thyroid hormones in a pediatric DS population. By integrating molecular, biochemical, and genetic markers, we reveal novel interactions among miR-33, \u003cem\u003eAPOE\u003c/em\u003e ε4, and thyroid hormones, providing insight into mechanisms linking metabolic dysfunction to neurological vulnerability. These findings suggest the potential value of early metabolic monitoring and genetic screening strategies in DS, with potential implications for anticipating and preventing neurodegenerative outcomes.\u003c/p\u003e\n\u003cp\u003eThese findings suggest the potential value of early metabolic monitoring and genetic screening strategies in DS, with potential implications for anticipating and preventing neurodegenerative outcomes.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eLIMITATIONS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study has several limitations that should be acknowledged when interpreting the results. The moderate sample size and cross-sectional design limit the ability to establish causal relationships or assess the temporal progression of the observed metabolic and molecular alterations. Moreover, the exclusive assessment of plasma miR-33 expression restricts a comprehensive understanding of its biological behavior, as its levels may vary across tissues and cellular compartments. This underscores the importance of incorporating tissue-based analyses or cellular models in future research to clarify its specific functional role in DS.\u003c/p\u003e\n\u003cp\u003eAnother relevant limitation is the low frequency of the \u003cem\u003eAPOE\u003c/em\u003e ε4 allele in the study cohort, which constrains the statistical power to draw robust conclusions about its genetic impact in this pediatric population. Additionally, age-related variations may influence miR-33 expression.\u003c/p\u003e\n\u003cp\u003eDespite these limitations, the present findings provide a valuable foundation for longitudinal investigations of the metabolic and genetic axes in DS. Future studies should explore the temporal evolution of miR-33 and \u003cem\u003eAPOE\u003c/em\u003e ε4 in relation to lipid homeostasis, thyroid function, and neurodegenerative risk. Expanding the cohort size will strengthen the generalizability of these results and help define the integrative role of these biomarkers in the metabolic and cognitive health of individuals with DS.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eThe findings of this study demonstrate that children and adolescents with Ds exhibit a distinctive metabolic profile characterized by lower expression of miR-33a and miR-33b, reduced HDL-c concentrations, and concomitant thyroid and glycemic alterations. Collectively, these features are associated with metabolic and neurodegenerative risk. The positive correlation between HbA1c and HDL-c, together with the negative association between total T4 and HDL-c, suggests a complex interplay among glucose, lipid, and thyroid regulatory pathways in this population, distinct from the pattern observed in individuals without DS. The association between the \u003cem\u003eAPOE\u003c/em\u003e \u0026epsilon;4 allele and lower HDL-c levels in the DS group further supports a functional interaction between cholesterol transport and neurodegenerative mechanisms linked to Alzheimer\u0026rsquo;s disease. This reinforces the concept that early metabolic disturbances are associated with neurological vulnerability in individuals with DS.\u003c/p\u003e\n\u003cp\u003eOverall, these results support the hypothesis of altered regulation of cholesterol homeostasis mediated by miR-33 dysregulation and thyroid dysfunction in the context of trisomy 21. They also highlight the importance of further investigating the interaction between miRNAs, genetic risk factors such as \u003cem\u003eAPOE\u003c/em\u003e \u0026epsilon;4, and metabolic pathways connecting lipid metabolism with neurodegeneration. These findings raise the possibility that the identified molecular and metabolic alterations could serve as early biomarkers, which may informe future research on personalized preventive and therapeutic strategies to reduce neurodegenerative risk and improve quality of life in the DS population.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eThe following abbreviations are used in this manuscript:\u003c/p\u003e\n\u003cp\u003eDS: Down syndrome\u003c/p\u003e\n\u003cp\u003eCTRL: Control\u003c/p\u003e\n\u003cp\u003emiRNAs: MicroRNAs\u003c/p\u003e\n\u003cp\u003emiR-33a: miR-33a-5p\u003c/p\u003e\n\u003cp\u003emiR-33b: miR-33b-3p\u003c/p\u003e\n\u003cp\u003eAPOE: Apoliporprote\u0026iacute;n E\u003c/p\u003e\n\u003cp\u003eHDL-c: High-density lipoprotein cholesterol\u003c/p\u003e\n\u003cp\u003eTC: Total cholesterol\u003c/p\u003e\n\u003cp\u003eTG: Triglycerides\u003c/p\u003e\n\u003cp\u003eLDL-c: Low-density lipoprotein cholesterol\u003c/p\u003e\n\u003cp\u003eVLDL-c: Very low-density lipoprotein cholesterol\u003c/p\u003e\n\u003cp\u003eGlu: Glucose\u003c/p\u003e\n\u003cp\u003eHbA1c: Glycated hemoglobin\u003c/p\u003e\n\u003cp\u003eAIP: Atherogenic index of plasma\u003c/p\u003e\n\u003cp\u003eTSH: Thyroid function parameters\u003c/p\u003e\n\u003cp\u003eT4: Thyroxine\u003c/p\u003e\n\u003cp\u003eT3: Triiodothyronine\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eEthics approval and consent to participate: The study received approval from the Research Ethics Committee of the Faculty of Medicine, Autonomous University of Sinaloa (registration number CONBIO\u0026Eacute;TICA-25-CEI-003-20181012), and was conducted in accordance with the ethical principles established in the Declaration of Helsinki. A written informed consent was obtained from the parent or legal guardian of each participant.\u003c/p\u003e\n\u003cp\u003eConsent for publication: All data were anonymized to protect participant confidentiality.\u003c/p\u003e\n\u003cp\u003eAvailability of data and materials: The datasets supporting the findings of this study can be obtained from the principal author ([email protected]), upon reasonable request. However, the data is not publicly accessible as it includes information that may compromise the confidentiality of the research participants.\u003c/p\u003e\n\u003cp\u003eCompeting interests: The authors declare no competing interests.\u003c/p\u003e\n\u003cp\u003eFunding: This research was funded by the Programa de Fomento y Apoyo a Proyectos de Investi-gaci\u0026oacute;n (PROFAPI 2022) under the project entitled \u0026ldquo;Effect of a Health Education Program for In-dividuals with Down Syndrome on Their Dietary Quality and Blood Metabolic Profile\u0026rdquo; (Project Code PRO_A3_020).\u003c/p\u003e\n\u003cp\u003eAuthors\u0026apos; contributions: Conceptualization: K.E.O., J.M.G. and C.A.R.; Methodology, K.E.O., W.G.E, T.S.A., L.C.Z., A.G.L and C.A.R.; Formal analysis, K.E.O., W.G.E., S.B.O., M.P.V., and R.Z.L.; Investigation, K.E.O., W.G.E., S.A.V. and M.P.V.; Data curation, K.E.O., W.G.E. and T.S.A.; Laboratory analyses: S.B.O., R.Z.L. and T.S.A; Supervision: J.M.G; Writing-original draft preparation: K.E.O. and J.M.G; Writing-review and editing: all authors.\u003c/p\u003e\n\u003cp\u003eAcknowledgements: The author gratefully acknowledges the support of the National Council for Humanities, Science, and Technology (CONAHCYT) through the postgraduate scholarship, which was instrumental in the completion of the master\u0026rsquo;s degree. Sincere appreciation is also extended to Dr. Carla Angulo Rojo for her invaluable mentorship and generosity throughout this work.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003ede Graaf G, Buckley F, Skotko BG. Estimation of the number of people with Down syndrome in the United States. Genet Med. 2017;19(4):439-47.\u003c/li\u003e\n\u003cli\u003eNetwork GBoDC. Global Burden Disease Study 2021 (GBD 2021) Results. Institute for Health Metrics and Evaluation. 2022.\u003c/li\u003e\n\u003cli\u003eIulita MF, Garz\u0026oacute;n Chavez D, Klitgaard Christensen M, Valle Tamayo N, Plana-Ripoll O, Rasmussen SA, et al. Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome. JAMA Netw Open. 2022;5(5):e2212910.\u003c/li\u003e\n\u003cli\u003ePenrsose L. Incidencia del mongolismo en la poblaci\u0026oacute;n general. 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MiR-33 contributes to the regulation of cholesterol homeostasis. 2010.\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"miR-33, APOE ε4, HDL cholesterol, thyroid hormones, Down syndrome","lastPublishedDoi":"10.21203/rs.3.rs-8845542/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8845542/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDown syndrome (DS), caused by trisomy 21, is associated with intellectual disability and early metabolic and neurodegenerative alterations. Cholesterol homeostasis, regulated by microRNAs (miRNAs), miR-33 through ABCA1 and HDL cholesterol (HDL-c) biogenesis, influences cognitive decline linked to the \u003cem\u003eAPOE ε\u003c/em\u003e4 isoform.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA cross-sectional study was conducted in 50 children and adolescents with Down syndrome (3–18 years) and matched controls, measuring miR-33a/b expression, lipid profiles, thyroid function, and APOE genotypes Statistical analyses included correlation and multivariate regression tests (p \u0026lt; 0.05).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe found significantly reduced miR-33a/b levels and lower HDL-c in DS participants, alongside frequent thyroid and glycemic abnormalities. The presence of the \u003cem\u003eAPOE ε\u003c/em\u003e4 allele correlated with decreased HDL-c in DS, suggesting a genetic-metabolic interaction contributing to neurological vulnerability.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThese findings suggest that dysregulation of miR-33 cknand thyroid hormones, combined with \u003cem\u003eAPOE\u003c/em\u003e ε4 status, may underlie early metabolic disturbances and increased neurodegenerative risk in DS, highlighting potential targets for personalized preventive and therapeutic strategies.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eRegistration\u003c/strong\u003e: The study protocol was reviewed and approved by the Ethics Committee of the Faculty of Medicine, Autonomous University of Sinaloa, with registration number CEI-FM-PI-2023-009, in accordance with current ethical standards and regulations.\u003c/p\u003e","manuscriptTitle":"Associations Among miR-33, APOE ε4, and Metabolic Markers in Down Syndrome Youth","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-02-25 16:54:44","doi":"10.21203/rs.3.rs-8845542/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"92c54419-3e5d-4391-b301-8ebd50166dc0","owner":[],"postedDate":"February 25th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-02-25T16:54:44+00:00","versionOfRecord":[],"versionCreatedAt":"2026-02-25 16:54:44","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8845542","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8845542","identity":"rs-8845542","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}