In Vitro Evaluation of the Erythrocyte Osmotic Fragility Potentials of Trigonella foenum-graecum and Syzygium aromaticum

In Vitro Evaluation of the Erythrocyte Osmotic Fragility Potentials of Trigonella foenum-graecum and Syzygium aromaticum | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 23 June 2025 V1 Latest version Share on In Vitro Evaluation of the Erythrocyte Osmotic Fragility Potentials of Trigonella foenum-graecum and Syzygium aromaticum Author : Marian Ameoze Adeku 0009-0001-2875-9057 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175070966.61006370/v1 179 views 89 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Erythrocyte membrane integrity plays a critical role in maintaining red blood cell functionality and lifespan. In sickle cell disease (SCD), oxidative damage and dehydration compromise erythrocyte stability. This study investigates the osmotic fragility effects of aqueous extracts of Trigonella foenum-graecum and Syzygium aromaticum, both individually and in combination. Using hypotonic saline solutions ranging from 0.1% to 0.9%, erythrocyte stability was assessed by spectrophotometric measurement of hemolysis. Results showed that all plant extracts conferred protective effects on sickled erythrocytes, particularly T. foenum-graecum decoction and the synergistic combination. These findings support their potential role in membrane stabilization therapy for SCD management. Supplementary Material File (adeku_marian_osmotic_fragility_manuscript.pdf) Download 191.87 KB Information & Authors Information Version history V1 Version 1 23 June 2025 Copyright This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License Keywords erythrocyte stabilization membrane integrity osmotic fragility sickle cell disease syzygium aromaticum trigonella foenumgraecum Authors Affiliations Marian Ameoze Adeku 0009-0001-2875-9057 [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 179 views 89 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Marian Ameoze Adeku. In Vitro Evaluation of the Erythrocyte Osmotic Fragility Potentials of Trigonella foenum-graecum and Syzygium aromaticum. Authorea . 23 June 2025. DOI: https://doi.org/10.22541/au.175070966.61006370/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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