Is it the Ideal Time to Start Prescribing Cannabis Derivatives to Treat Endometriosis-associated Pain?

Omero Benedicto Poli‐Neto, Jorge Hallak, Júlio César Rosa e Silva, José Alexandre S. Crippa
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022 · vol. 44(05) , pp. 449–451 · doi:10.1055/s-0042-1749430 · PMID:35697067 · W4282825119
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Abstract

Endometriosis affects ∼5%-10% of women of reproductive age and is often associated with painful symptoms like dysmenorrhea, dyschezia, dyspareunia, and even non cyclical pain.[1] The disease is diagnosed in at least 20% of women with dysmenorrhea and/or non-menstrual pelvic pain, reaching a prevalence of 50% among adolescents.[2] There is an alignment among international societies[3] [4] that the presumed diagnosis of this disease is enough to start clinical treatment. Moreover, there seems to be a consensus that first-line treatment should be hormonal contraceptives since the efficacy is similar to that of surgery but with lower complication rates and costs.[5] However, these drugs are effective in only approximately two-thirds of patients,[6] have limited long-term efficacy,[7] and may occasionally lead to undesirable side effects. Additionally, there are serious limitations in the interpretation of clinical trials.[8] Accordingly, evidence on the best therapeutic regimens has not yet been established.[9] Other clinical options exist, but the cost, side effects, and similarity of results compared with hormonal contraceptives give them limited utility.[10] Thus, due to the persistence of pain, a significant portion of women undergo surgery, which is obviously capable of eliminating visible endometriotic lesions, but not curing the disease.[11] Despite short-term clinical improvement, postoperative recurrence is common, especially if hormone therapy was not initiated.[12]

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Condition tags

mesh:D004715endometriosisdysmenorrheadyspareunia

MeSH descriptors

Cannabis Cannabis Cannabis Cannabis Cannabis Cannabis Cannabis Cannabis Cannabis Cannabis Cannabis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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