Comparison the effects and side effects of Covid-19 vaccination in patients with inflammatory bowel disease (IBD); A systematic scoping review

Covid-19 disease is a pandemic disease that maybe more severe and mortal in people with immunodeficiency, such as those with inflammatory bowel disease (IBD), who are taking immunosuppressive drugs. On the other hand, no definitive treatment has been identified for it and the best way to control it is wide spread vaccination. The aim of this study was to evaluate the benefits and side effects of different vaccines in patients with IBD. Three Electronic databases [Medline (accessed from PubMed), Scopus, Science Direct, and Cochrane] were searched systematically without time limit, using MESH terms and the related keywords in English language. Considering the titles and abstracts, unrelated studies were excluded. The full texts of the remained studies were evaluated by authors, independently. Then, the studies' findings were assessed and reported. Total of 212 articles were obtained within the first step of searching, and 147 ones remained after removing the duplications. Through the title and abstract screening, 127 were removed. Finally, after reading the full text of the remained articles, 15 ones included in data extraction. All included studied were research study, and most of them (12/15) had prospective design. Totally, 8/15 studies were performed in single-center settings. In 8/15 studies, patients with IBD were compared with a control group. The results were summarized the in two categories: 1) the effect of vaccination, and 2) side effects. The effect of vaccination were assessed in 13/15 studies. Side effects of Covid-19 vaccination in patients with IBD were reported in 7/15 studies. Patients with IBD can be advised that vaccination may have limited minor side effects, but it can protect them from the serious complications of Covid-19 disease and its resulting mortality with a high success rate. They should be also mentioned in booster doses.