Obtention of crosslinked hybrid films from xanthan gum and 3-(trimethoxysilyl)propyl methacrylate for controlled drug delivery

Obtention of crosslinked hybrid films from xanthan gum and 3-(trimethoxysilyl)propyl methacrylate for controlled drug delivery | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Obtention of crosslinked hybrid films from xanthan gum and 3-(trimethoxysilyl)propyl methacrylate for controlled drug delivery Alejandra Ortega, Eduardo Toral, Guillermina Burillo, Lorena García-Uriostegui This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4139040/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Modification of natural polymers with inorganic molecules is a good alternative to develop new hybrid materials by biomedical applications, taking advantage of its inherent properties such as biodegradability, biocompatibility, non-toxicity and low cost. In this work, films of xanthan gum (XG) and 3-(trimethoxysilyl)propyl methacrylate (TMPS) were crosslinked by gamma radiation in solid state, and their potential application as drug delivery system loading narrow- and broad-spectrum antibiotics (vancomycin and ciprofloxacin) were studied. The parameters evaluated in the crosslinking process were dose and TMPS concentration, obtaining the highest crosslinking percentage at 15 kGy and 200% TMPS. The incorporation of silane compound was confirmed by infrared spectroscopy (FTIR) and thermal analysis (TGA), indicating that reticulation process was successful carried out and TMPS was incorporated of material. Also, swelling behaviour, contact angle and scanning electronic microscopy (SEM) of crosslinked films were evaluated, showing materials with good porosity and hydrophilicity. The studies of drug delivery displayed excellent results for vancomycin, loading 110 mg g -1 approximately and releasing more of 95%, while ciprofloxacin was able to load until 4 mg g -1 and released 80%. Gamma radiation Xanthan gum Hybrid material Hydrogels Drug delivery systems TMPS Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4139040","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":282567606,"identity":"282dd03d-4c5a-4d39-a51e-b512dc337b5c","order_by":0,"name":"Alejandra Ortega","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABT0lEQVRIie2RMUvDQBTHXwmcy5VbI8H2EwgvBAIlaL9KSsAuQgsuBWMNBDKpXc9voQjF8cpBsgRcA3Ho1E0ICIKDxUsXkxbsKpg/3OPdO373f3cPoFGjv6gDAATQfgqsDMvfEK2KCLUOAxXcPQjUEBR7EBZqYvz57IxYoMXvxeSqa+U3ZuFOTkeMCWKM/Tkc89oNuiSueZsOe1wQj4s0MeevqaW7qde75y4xeJyDnYqajaSI7UgiCGrBIopb8+zchkGkIWZADEoUkgRVoitZYX4ppLtB1nH/iZfI+hr7L6oxulaIrJmgpGCVLrhBAn/woJdIoCqgGmtHOy6mJGgdRUNUiQdpLDyenV3obpygng1Cp32X0623dJJwZb5FDqpEwsSfnsy491gU/iWymVzk9CPv2Nn2nxOsjKbWdmvTEN0djbasbKa7540aNWr07/UNmkp5/Yf3QFoAAAAASUVORK5CYII=","orcid":"","institution":"Universidad Nacional Autónoma de México","correspondingAuthor":true,"prefix":"","firstName":"Alejandra","middleName":"","lastName":"Ortega","suffix":""},{"id":282567608,"identity":"4ca4d93a-128a-4bf0-89c0-2dc50dca5850","order_by":1,"name":"Eduardo Toral","email":"","orcid":"","institution":"Universidad Nacional Autónoma de México","correspondingAuthor":false,"prefix":"","firstName":"Eduardo","middleName":"","lastName":"Toral","suffix":""},{"id":282567610,"identity":"a4f7fbfc-8ad2-4b5c-b93f-ebde6d4b492e","order_by":2,"name":"Guillermina Burillo","email":"","orcid":"","institution":"Universidad Nacional Autónoma de México","correspondingAuthor":false,"prefix":"","firstName":"Guillermina","middleName":"","lastName":"Burillo","suffix":""},{"id":282567612,"identity":"0d7b7878-3d57-4a0f-85f0-d33303cd1f21","order_by":3,"name":"Lorena García-Uriostegui","email":"","orcid":"","institution":"Universidad de Guadalajara","correspondingAuthor":false,"prefix":"","firstName":"Lorena","middleName":"","lastName":"García-Uriostegui","suffix":""}],"badges":[],"createdAt":"2024-03-20 18:30:55","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4139040/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4139040/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":60732260,"identity":"d2cbbc6b-bc3e-435c-999f-742fdc1b0403","added_by":"auto","created_at":"2024-07-20 09:02:57","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":777553,"visible":true,"origin":"","legend":"","description":"","filename":"ManuscriptTMPSPolymerBulletinFinal1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4139040/v1_covered_3664ba91-2615-4517-ab9c-2fe8bd75bb74.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Obtention of crosslinked hybrid films from xanthan gum and 3-(trimethoxysilyl)propyl methacrylate for controlled drug delivery","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Gamma radiation, Xanthan gum, Hybrid material, Hydrogels, Drug delivery systems, TMPS","lastPublishedDoi":"10.21203/rs.3.rs-4139040/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4139040/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eModification of natural polymers with inorganic molecules is a good alternative to develop new hybrid materials by biomedical applications, taking advantage of its inherent properties such as biodegradability, biocompatibility, non-toxicity and low cost. In this work, films of xanthan gum (XG) and 3-(trimethoxysilyl)propyl methacrylate (TMPS) were crosslinked by gamma radiation in solid state, and their potential application as drug delivery system loading narrow- and broad-spectrum antibiotics (vancomycin and ciprofloxacin) were studied. The parameters evaluated in the crosslinking process were dose and TMPS concentration, obtaining the highest crosslinking percentage at 15 kGy and 200% TMPS. The incorporation of silane compound was confirmed by infrared spectroscopy (FTIR) and thermal analysis (TGA), indicating that reticulation process was successful carried out and TMPS was incorporated of material. Also, swelling behaviour, contact angle and scanning electronic microscopy (SEM) of crosslinked films were evaluated, showing materials with good porosity and hydrophilicity. 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