MECHANISMS OF REPRODUCTIVE FUNCTION IMPAIRMENT IN UTERINE MYOMA AND ENDOMETRIOSIS: CLINICAL-DIAGNOSTIC FEATURES AND MODERN APPROACHES

Ulug'ova Muxlisa Normamatovna, Egamova Feruza Zikriyaxon qizi, Axtamova Nilufar Akbarjanovna
2026 · doi:10.5281/zenodo.20390442 · W7162460901
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Uterine myoma and endometriosis, common gynecological pathologies that frequently coexist, impair female fertility through diverse mechanisms including anatomical distortion and microscopic changes in endometrial receptivity and pelvic immunology.

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Abstract

Uterine myoma (leiomyoma) and endometriosis are two of the most prevalent benign gynecological pathologies, frequently coexisting and acting as profound drivers of female infertility. Their mechanisms of reproductive impairment are multifaceted, ranging from gross anatomical distortion to microscopic alterations in endometrial receptivity and local pelvic immunology.
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Published May 26, 2026 | Version v1 Dataset Open MECHANISMS OF REPRODUCTIVE FUNCTION IMPAIRMENT IN UTERINE MYOMA AND ENDOMETRIOSIS: CLINICAL-DIAGNOSTIC FEATURES AND MODERN APPROACHES Authors/Creators - 1. Samarkand State Medical University, Samarkand, Uzbekistan Description Uterine myoma (leiomyoma) and endometriosis are two of the most prevalent benign gynecological pathologies, frequently coexisting and acting as profound drivers of female infertility. Their mechanisms of reproductive impairment are multifaceted, ranging from gross anatomical distortion to microscopic alterations in endometrial receptivity and local pelvic immunology. Files 1947-1953.pdf Files (458.4 kB) | Name | Size | Download all | |---|---|---| | md5:4f7387ab5e77a3b174e07dc4274a6dfd | 458.4 kB | Preview Download | Additional details References - 1.Taylor, H. S., Kotlyar, A. M., & Flores, V. A. (2021). Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. The Lancet, 397(10276), 839-852. - 2.Lessey, B. A., & Young, S. L. (2019). What exactly is endometrial receptivity?. Fertility and Sterility, 111(4), 611-617. - 3.Donnez, J., & Dolmans, M. M. (2020). Uterine fibroid management: From the present to the future. Human Reproduction Update, 26(2), 222-240. - 4.Stewart, E. A., Cookson, C. L., Gandolfo, C. G., & Schulze-Rath, R. (2017). Epidemiology of uterine fibroids: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology, 124(10), 1501-1512. - 5.Zepiridis, L. I., Grimbizis, G. F., & Tarlatzis, B. C. (2016). Infertility and uterine fibroids. Best Practice & Research Clinical Obstetrics & Gynaecology, 34, 66-73.

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