Investigating the antibacterial, anti-motility and anti-biofilm potential of Syzygium cumini mediated silver nanoparticles against emerging multi-drug resistant nosocomial pathogens

Abstract The current landscape of antibiotic failures promotes researchers to turn their attention to nanotechnology. Therefore, in this study silver nanoparticles (AgNPs) were synthesized by using the leaf extract of Syzygium cumini. The spectrum of biosynthesized silver nanoparticles was noticed at 432 nm displaying a bell-shaped curve under UV-Vis spectroscopy. Transmission electron microscopy (TEM) showed that these nanoparticles have a spherical shape and diameter of 50–60 nm. FT-IR study has revealed the presence of phenolics, aromatic, and alkynes groups in the synthesized nanoparticles. These biosynthesized AgNPs were processed for antibacterial,anti-motility, and anti-biofilm activity. Results showed that AgNPs exhibit good antibacterial activity. A significant reduction in motility patterns has been visualized by the effect of AgNPs against P. aeruginosa and A. baumannii. Substantial and structural reduction in P. aeruginosa and A. baumannii biofilm morphology was also examined by the effect of AgNPs. Hence greener route of AgNPs synthesis may be validated as a feasible substitute in eliminating the infection caused by multi-drug resistant nosocomial pathogens.