An Umbrella Systematic Literature Review to aid the development of a Combined Physical and Psychological Programme for the management of Chronic Traumatic Encephalopathy

An Umbrella Systematic Literature Review to aid the development of a Combined Physical and Psychological Programme for the management of Chronic Traumatic Encephalopathy | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Systematic Review An Umbrella Systematic Literature Review to aid the development of a Combined Physical and Psychological Programme for the management of Chronic Traumatic Encephalopathy Benjamin Ashworth, Joanne Godley, Dr. Anne Daykin This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8056734/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Objective To systematically review related tauopathies to aid the development of a combined physical and psychological programme for managing chronic traumatic encephalopathy symptoms. Design: Umbrella Systematic Literature Review. Data Sources: CINAHL, MEDLINE, SPORTDiscus, APA PsycInfo, Psychology and Behavioral Sciences Collection, and APA PsycArticles. Eligibility Criteria: Studies included had to (1) be a related tauopathy (Alzheimer’s disease; Parkinson’s disease; Lewy Body dementia; Frontotemporal degeneration; Corticobasal degeneration; Supranuclear Palsy); (2) utilise either active rehabilitation or psychological rehabilitation as their selected intervention in a non-pharmacological capacity; (3) measure symptoms associated with chronic traumatic encephalopathy. Included studies were assessed using the Assessing the Methodological Quality of Systematic Reviews for methodological assessment; Risk of Bias in Systematic Reviews for risk of bias assessment; Cochrane GRADE tool for evidence quality assessment. Results Twenty-three systematic literature reviews met the inclusion criteria. Six articles were excluded for poor methodological and/or evidence quality. Risk of bias was low. Mood and cognitive symptoms improved when using active and psychological interventions respectively. Motor symptoms improved only with use of active rehabilitation. Mind-body exercises and cognitive behavioural therapy were found to be especially effective. Conclusion Active, and psychological rehabilitation techniques were found to be viable interventions for managing related tauopathies. This could then theoretically apply to the management of chronic traumatic encephalopathy symptoms as a combined intervention. However, more research is required to assess the efficacy of combined interventions. Sports Medicine and Kinesiology Chronic Traumatic Encephalopathy Active Rehabilitation Psychological Rehabilitation Combined Physical and Psychological Programme Mind-Body Exercises Cognitive Behavioural Therapy. Figures Figure 1 Figure 2 Full Text Additional Declarations The authors declare no competing interests. Supplementary Files SLRCharacteristics.docx SLR Characteristics Appendix1.AMSTAR2.xlsx Appendix 1. AMSTAR 2 Appendix2.12.23ROBIS.xlsx Appeendix 2.1; 2.2; 3 ROBIS Appendix4.GRADE.xlsx Appendix 4. GRADE Appendix5.CitationMatrix.xlsx Appendix 5. Citation Matrix Appendix6.OutcomeMeasureFrequency.xlsx Appendix 6. Outcome Measure Frequency Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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AMSTAR 2\u003c/p\u003e","description":"","filename":"Appendix1.AMSTAR2.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-8056734/v2/a9593c25bb40a9eaa2d5f116.xlsx"},{"id":97368792,"identity":"a7856b17-19e2-4a23-b7c8-011a2e448444","added_by":"auto","created_at":"2025-12-03 16:22:56","extension":"xlsx","order_by":3,"title":"","display":"","copyAsset":false,"role":"supplement","size":1039499,"visible":true,"origin":"","legend":"\u003cp\u003eAppeendix 2.1; 2.2; 3 ROBIS\u003c/p\u003e","description":"","filename":"Appendix2.12.23ROBIS.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-8056734/v2/b0315bfbf4784421de7f3ad3.xlsx"},{"id":97368451,"identity":"dc0e44c5-de7b-4ebb-887d-664482cd5247","added_by":"auto","created_at":"2025-12-03 16:22:17","extension":"xlsx","order_by":4,"title":"","display":"","copyAsset":false,"role":"supplement","size":169205,"visible":true,"origin":"","legend":"\u003cp\u003eAppendix 4. GRADE\u003c/p\u003e","description":"","filename":"Appendix4.GRADE.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-8056734/v2/8c445e2c2da421bace1b6e91.xlsx"},{"id":97368915,"identity":"2bfb8a81-8519-40ef-8892-4f1a78e84c81","added_by":"auto","created_at":"2025-12-03 16:23:13","extension":"xlsx","order_by":5,"title":"","display":"","copyAsset":false,"role":"supplement","size":56936,"visible":true,"origin":"","legend":"\u003cp\u003eAppendix 5. Citation Matrix\u003c/p\u003e","description":"","filename":"Appendix5.CitationMatrix.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-8056734/v2/90d49b83a31ec4fdbc03882c.xlsx"},{"id":97368234,"identity":"488b5538-ad40-49c5-aa44-3b41ab548edc","added_by":"auto","created_at":"2025-12-03 16:21:51","extension":"xlsx","order_by":6,"title":"","display":"","copyAsset":false,"role":"supplement","size":65069,"visible":true,"origin":"","legend":"\u003cp\u003eAppendix 6. 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Included studies were assessed using the Assessing the Methodological Quality of Systematic Reviews for methodological assessment; Risk of Bias in Systematic Reviews for risk of bias assessment; Cochrane GRADE tool for evidence quality assessment.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e\u003cp\u003eTwenty-three systematic literature reviews met the inclusion criteria. Six articles were excluded for poor methodological and/or evidence quality. Risk of bias was low. Mood and cognitive symptoms improved when using active and psychological interventions respectively. Motor symptoms improved only with use of active rehabilitation. Mind-body exercises and cognitive behavioural therapy were found to be especially effective.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e\u003cp\u003eActive, and psychological rehabilitation techniques were found to be viable interventions for managing related tauopathies. This could then theoretically apply to the management of chronic traumatic encephalopathy symptoms as a combined intervention. However, more research is required to assess the efficacy of combined interventions.\u003c/p\u003e","manuscriptTitle":"An Umbrella Systematic Literature Review to aid the development of a Combined Physical and Psychological Programme for the management of Chronic Traumatic Encephalopathy","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2025-12-02 19:16:17","doi":"10.21203/rs.3.rs-8056734/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2025-11-10 13:49:24","doi":"10.21203/rs.3.rs-8056734/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"add22cfa-7d15-4dac-ba95-abcabdb51879","owner":[],"postedDate":"December 2nd, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":57734790,"name":"Sports Medicine and Kinesiology"}],"tags":[],"updatedAt":"2025-11-10T13:49:24+00:00","versionOfRecord":[],"versionCreatedAt":"2025-12-02 19:16:17","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-8056734","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8056734","identity":"rs-8056734","version":["v2"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}