Postovulatory endometrial development in women with I.U.D

H H Nicolaisen, Hans Henrik Nicolaisen, Henning Pedersen, H Pedersen, E Guttorm, Eigil Guttorm, Heinrich Rebbe, H Rebbe
Acta obstetricia et gynecologica Scandinavica · 1973 · vol. 52(3) , pp. 253–258 · doi:10.3109/00016347309158323 · PMID:4126520 · W2095015485
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Histological dating of endometrial biopsies revealed that intrauterine device users exhibited a statistically significant two-day retardation in postovulatory endometrial development compared to controls, suggesting this delay contributes to the contraceptive effect.

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Abstract

Abstract. Histological “dating” of endometrial biopsy specimens within the postovulatory period was performed in a group of normal women having an I.U.D. and another group of normal women without an I.U.D. In both groups the time of ovulation was determined by basal temperature measurement. By comparing the “histological” date with the actual point of time in the cycle, given in days after the ovulation, the group of women with an I.U.D. showed an average retardation of 2 days. In the control group the average retardation was zero days. The difference between the two groups was statistically significant. The group with an I.U.D. presented focal stromal changes, which should be investigated further with a view to a possible endocrine secretion. The results of the present investigation of a fairly small series show that the contraceptive effect of an I.U.D. may be due to delayed endometrial development.

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MeSH descriptors

Endometrium Intrauterine Devices Ovulation Biopsy Body Temperature Cytoplasmic Granules Endometrium Endometrium Epithelial Cells Female Glycosaminoglycans Glycosaminoglycans Humans Pregnanediol Pregnanediol Staining and Labeling

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