Association Between Dietary Diabetes Risk Reduction Score and Chronic Kidney Disease in Adults: Tehran Lipid and Glucose Study

Aims: : To examine the association of dietary diabetes risk reduction score (DDRRS) with chronic kidney disease (CKD) among an Iranian population. Methods: : We followed-up 2076 ≥ 20 years old participants of Tehran Lipid and Glucose Study (2006-2008), who were initially free of CKD for 5.98 years. Dietary diabetes risk reduction score was calculated on the basis of scoring eight components using a valid and reliable 168-item food frequency questionnaire. CKD was defined as estimated glumerular filtration rate (eGFR) <60 mL/min/1.73 m 2 . A Cox proportional hazard regression model was used to assess association between the quartiles of DDRRS and incidence of CKD. Results: : Mean ± SD age of the study population (53% women) was 37.6 ± 12.61 years. A total of 357 incident cases of CKD were reported. The median (25-75 interquartile range) of DDRRS was 20 (18-22). After adjustment for age, sex, smoking status, total energy intake, body mass index, hypertension, diabetes, eGFR, and physical activity, individuals in the highest versus lowest quartile of DDRRS were 33% less likely to have CKD (OR: 0.67; 95% CI: 0.48-0.96, P for trend: 0.043). Conclusion: Our findings suggest an inverse association between DDRRS and risk of incident CKD in the fourth versus first quartile of DDRRS.