Experimental research of GuiFu capsule in treating endometriosis

Objective: To study the effect of GuiFu capsule on sexual hormone and other relative factors in rats with endometriosis.Methods: Endometriosis was induced in rats by surgery of self-endometrium transplant.Rats with successful models were randomized into GuiFu capsule group and Danazol group.Expressions of ER,PR,VEGF and NK cells were examined by immunohistochemical stainin;the level of E2 and P was detected by radioimmunoassay.Results: GuiFu capsule can reduce the level of E2 and P in the blood of rats(P0.01);lower the content of ER and PR in ectopia endometrium(P0.05);raise the activity of NK cells(P0.05);and restrain the generation of VEGF.The experiment results of Guifu capsule are close to those of Danazol.Conclusion: GuiFu capsule can inhibit the growth of ectopica endometrium by regularing patient's endocrine.At the same time,it increases the activity of NK cells to reinforce their effect of getting rid of the ectopia endometrium.