Endometriosis and CYP 19 Gene Polymorphisms

Endometriosis(EMs) is one of the common gynecological diseases,the pathology showed benign morphological changes of but with a similar malignant tumors characteristics of planting,erosion and distant metastasis.EMs is an estrogen-dependent diseases,CYP 19 gene expression is closely related to the production of estrogen,and its mutations may alter estrogen exposure,thereby affecting the pathogenesis of endometriosis.Currently on the CYP 19 gene polymorphism and the relationship between EMs are still controversial and need further study to clarify the role of the aromatase gene polymorphism in the occurrence of EMs.