Observation on the clinical efficacy of levonorgestrel-intrauterine releasing system

Objective:To explore the clinical efficacy of levonorgestrel-intrauterine releasing system(LNG-IUS) for contraception,adenomyosis,hysteromyoma and dysfunctional uterine bleeding.Methods:LNG-IUS was placed in 94 patients with induced abortion,adenomyosis,hysteromyoma and dysfunctional uterine bleeding in the hospital from December 2003 to March 2007.The factors such as contraceptive effectiveness,menstruation,hemoglobin and blood CA125 levels were observed at 1,3,6 and 12 months after placement of LNG-IUS.Results:Among 30 cases with induced abortion,LNG-IUS of one case dropped after 20 days and she got pregnancy at five months;among the other 29 cases,20.00% of the cases had abdominal pain,then the pain was relieved after 3 months;70.00% of the cases were found with irregular vaginal bleeding,then they recovered after 6 months.Among 64 cases with adenomyosis,hysteromyoma and dysfunctional uterine bleeding,LNG-IUS of one case moved down after 1 month.Dysmenorrhea of all the cases relieved after 3 months.At 12 months,the amount of menstruation reduced by 89.26%,the menstruation shortened by 3.58 days,the menstrual cycle prolonged by 6.51 days,the incidence of amenorrhea was 57.81%,the level of hemoglobin increased by 2.91 g/L,and the level of CA125 decreased by 40.10%,the volumes of uteri and fibroids decreased significantly.No uterine cavity infection and pregnancy with IUD occurred.Conclusion:LNG-IUS has good contraceptive effect,and it is also effective for adenomyosis,hysteromyoma and dysfunctional uterine bleeding.