From breakdown to repair: A human organoid model of menstruation
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This paper describes the development of a human organoid model to study the breakdown and repair processes of the uterine lining during menstruation.
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Abstract
Menstruation entails repeated cycles of cyclical shedding and scarless regeneration of the endometrium, yet the precise cellular states underlying this process have remained poorly defined. In this issue, Nikolakopoulou et al. establish an in vitro menstrual cycle (IVMC) protocol using human endometrial organoids, revealing WNT7A as a central regulator of epithelial regeneration.
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Too few in-corpus citations on either side for a chart; here are the lists.
Cites (4)
- Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium 2017
- Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability 2017
- Mechanisms of Regeneration and Fibrosis in the Endometrium 2023
- Dynamic Regulation of Wnt7a Expression in the Primate Endometrium: Implications for Postmenstrual Regeneration and Secretory Transformation 2012
References (9)
- Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability via openalex
- Dynamic Regulation of Wnt7a Expression in the Primate Endometrium: Implications for Postmenstrual Regeneration and Secretory Transformation via openalex
- Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium via openalex
- Mechanisms of Regeneration and Fibrosis in the Endometrium via openalex
- W2111608265 via openalex
- W2982312837 via openalex
- W4385760537 via openalex
- W2958037602 via openalex
- W2065643273 via openalex
SciLite annotations
organisms 2
human
human
Source provenance
- openalex
- last seen: 2026-07-31T06:01:29.331002+00:00
- scilite
- last seen: 2026-07-12T09:48:33.364277+00:00
License: CC0
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