Human Reproduction vol.8 no.4 pp.547-551. 1993 Does contraception modify the risk of endometriosis?

'To whom correspondence should be addressed Long episodes of regular, prolonged, abundant menstrual flows are generally agreed to increase the risk of endometriosis. Since oral oestrogen-progestogen combina-tions reduce and intra-uterine contraceptive devices increase menstrual flow, an effect on the risk of development of endometriosis in women utilizing these forms of contracep-tion could be expected. Analysis of the most recent epidemiological observations shows no consensus on a possible relationship between use of cyclic oral contraceptives and endometriosis, with an increase, a decrease, and no effect on the risk of developing the disease all being reported. A lower relative risk of endometriosis in previous users of the intra-uterine contraceptive device was only found in two series, most of the other data suggesting a rise in risk or no effect.