Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

Hywel D. Williams; Yasemin Sahbaz; Leigh Ford; Tri‐Hung Nguyen; Peter J. Scammells; Christopher J. H. Porter

doi:10.1039/c3cc48650h

Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

Hywel D. Williams, Yasemin Sahbaz, Leigh Ford, Tri‐Hung Nguyen, Peter J. Scammells, Christopher J. H. Porter

In: Chem. Commun. · 2013 · vol. 50(14) , pp. 1688–1690 · doi:10.1039/c3cc48650h · PMID:24394756 · W2170641162

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Abstract

Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.

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Cites (1)

Effect of Food and a Monoglyceride Emulsion Formulation on Danazol Bioavailability 1993

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SciLite annotations

chemicals 6

water water danazol itraconazole danazol lipid

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[1] Effect of Food and a Monoglyceride Emulsion Formulation on Danazol Bioavailability 1993