Modern options of outpatient treatment of chronic inflammatory diseases in fertile aged women caused
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This study evaluated the outpatient treatment efficacy of a ciprofloxacin and ornidazole combination for chronic pelvic inflammatory diseases in 100 fertile-aged women with mixed infections. The results indicated that sexually transmitted pathogens, particularly Chlamydia trachomatis and Ureaplasma urealyticum, were the primary drivers of vaginal dysbiosis and inflammation in this cohort. Treatment with the specified antibiotic regimen significantly reduced pathogenic microflora and demonstrated a 95% effectiveness rate in resolving the lower genital tract infections. Relevance to endometriosis: listed as one comorbidity diagnosed in 11% of the examined patients, though the paper's main focus is infectious pelvic inflammatory disease.
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Abstract
The objective: to evaluate the outpatient treatment of chronic pelvic inflammatory diseases of fertile aged women caused by mixed infection, including Chlamydia. Patients and methods. We examined 100 women chronic pelvic inflammatory diseases determining vaginal microbiota condition before and after treatment. Provided research of efficiency in the treatment of drug containing ciprofloxacin – and ornidazole 500 mg – 500 mg (Ortsypol) in women with chronic pelvic inflammatory diseases in lower levels of genital tract. Analysis of the vaginal bacterial spectrum and records of the results was performed according to the order number 234 of the Ministry of Health of Ukraine 2005 Results. Our results have shown that most women suffered from chronic pelvic inflammatory diseases in lower level of genital tract during one year (30%), slightly less women had disease duration of 3 years (27%) and 5 years (25%). Among other gynecological diseases in examined women often diagnosed cervical erosion (14%) and the polycystic ovarian syndrome (18%). Often diagnosed ovarian cysts (10%), endometriosis (11%) and endometrial hyperplasia (9%). Examination of vaginal mikrobiome in fertile aged women with chronic pelvic inflammatory diseases showed increased number of resident microflora and STIs, mainly: Chlamidya trahomatis (25%), Ureaplasma urealiticum (23%). We observed significant reduction of the number of pathogenic and conditionally pathogenic microflora in fertile aged women with chronic pelvic inflammatory diseases after treatment rizke. Conclusion. 1. The most common cause of vaginal dysbiosis in women that were attending outpatient clinic, were sexually transmitted infections, among which most commonly we diagnosed Chlamidya trahomatis. 2. In the development of inflammatory reactions in reproductive organs and chronic pelvic inflammatory diseases main role plays microbial and viral and microbial associations in which Chlamidya trahomatis and Ureaplasma urealiticum are present. 3. Use of a complex chronic pelvic inflammatory diseases treatment of lower genital tract using Ortsypol shown to be highly effective (95%). Key words: chronic inflammatory diseases, fertile aged women, infections, sexually transmitted infections, outpatient treatment, Ortsypol.
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- Modern options of outpatient treatment of chronic inflammatory diseases in fertile aged women caused
Modern options of outpatient treatment of chronic inflammatory diseases in fertile aged women caused
HEALTH OF WOMAN. 2017.5(121):132–136; doi 10.15574/HW.2017.121.132
Podolskyi Vl. V., Podolskyi V. V.
SI «Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine», Kiev
The objective: to evaluate the outpatient treatment of chronic pelvic inflammatory diseases of fertile aged women caused by mixed infection, including Chlamydia.
Patients and methods. We examined 100 women chronic pelvic inflammatory diseases determining vaginal microbiota condition before and after treatment. Provided research of efficiency in the treatment of drug containing ciprofloxacin – and ornidazole 500 mg – 500 mg (Ortsypol) in women with chronic pelvic inflammatory diseases in lower levels of genital tract.
Analysis of the vaginal bacterial spectrum and records of the results was performed according to the order number 234 of the Ministry of Health of Ukraine 2005
Results. Our results have shown that most women suffered from chronic pelvic inflammatory diseases in lower level of genital tract during one year (30%), slightly less women had disease duration of 3 years (27%) and 5 years (25%).
Among other gynecological diseases in examined women often diagnosed cervical erosion (14%) and the polycystic ovarian syndrome (18%). Often diagnosed ovarian cysts (10%), endometriosis (11%) and endometrial hyperplasia (9%).
Examination of vaginal mikrobiome in fertile aged women with chronic pelvic inflammatory diseases showed increased number of resident microflora and STIs, mainly: Chlamidya trahomatis (25%), Ureaplasma urealiticum (23%).
We observed significant reduction of the number of pathogenic and conditionally pathogenic microflora in fertile aged women with chronic pelvic inflammatory diseases after treatment rizke.
Conclusion. 1. The most common cause of vaginal dysbiosis in women that were attending outpatient clinic, were sexually transmitted infections, among which most commonly we diagnosed Chlamidya trahomatis.
2. In the development of inflammatory reactions in reproductive organs and chronic pelvic inflammatory diseases main role plays microbial and viral and microbial associations in which Chlamidya trahomatis and Ureaplasma urealiticum are present.
3. Use of a complex chronic pelvic inflammatory diseases treatment of lower genital tract using Ortsypol shown to be highly effective (95%).
Key words: chronic inflammatory diseases, fertile aged women, infections, sexually transmitted infections, outpatient treatment, Ortsypol.
References
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10. Savaris RF, Fuhrich DG, Duarte RV, Franik S, Ross J. 2017, Apr 24. Antibiotic therapy for pelvic inflammatory disease. Cochrane Database Syst Rev. 4:CD010285. doi: 10.1002/ 14651858. CD010285.pub2.
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12. O’Connell CM, Ferone ME. 2016, Sep 5. Chlamydia trachomatis Genital Infections. Microb Cell. 3(9):390-403. doi: 10.15698/ mic2016.09.525.
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