Therapeutic Efficacy of Mifepristone and Gestrinone on Adenomyosis

Objective To investigate the effect of mifepristone and gestrinone on adenomyosis.Methods 76 patients with adenomyosis,who volunteered for medicine treatment,were randomly divided into two groups: Group 1(mifepristone group) and Group 2(gestrinone group).Group 1 took mifepristone 10 mg,per day from the first day of menstruation.Group 2 took gestrinone 2.5 mg twice per week,one on the first menstrual day and the other three days later.The administration was the same every week afterwards.The two groups followed the administration respectively for 6 consecutive months.Their dysmenorrheal,amenorrhea,gastrointestinal reactions,liver function,sex hormone level changes,uterine size and recurrence before the treatment and 6 months after the treatment were compared.Results The situation of Group 1 after 6 months of administration showed no remarkable difference compared with that of Group 2 in terms of remission rate,dysmenorrheal rate,amenorrhea rate,serum FSH,LH and E2 levels and recurrence incidence after medication withdrawal(P0.05).But the difference in gastrointestinal reactions,the incidence of abnormal liver function,serum P levels adn changes in uterine size was significant(P0.05).Conclusion Compared with gestrinone,mifepristone is safer,more effective and free from side effects in the treatment of adenomyosis.