Distinct Subpopulations of Elicited Human Macrophages in Peritoneal Dialysis Patients and Women Undergoing Laparoscopy: A Study on Peroxidatic Activity

H.J. Bos, H van Bronswijk, Th.J.M. Helmerhorst, P. L. Oe, E.C.M. Hoefsmit, R.H.J. Beelen
In: Journal of Leukocyte Biology · 1988 · vol. 43(2) , pp. 172–178 · doi:10.1002/jlb.43.2.172 · PMID:3422087 · W2404244749
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This study analyzed peritoneal macrophages from CAPD patients and healthy women, finding distinct peroxidatic activity patterns that suggest chronic sterile inflammation and reveal how short culture periods alter macrophage developmental stages.

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Abstract

The endogenous peroxidatic activity (PA) pattern of peritoneal macrophages from 24 continuous ambulatory peritoneal dialysis (CAPD) patients and from five healthy women undergoing laparoscopy was studied. In general, the macrophages showed two different PA patterns in vivo: exudate and negative macrophages. However, two of 24 CAPD patients showed resident macrophages, the first described in vivo in man. Since, in general, the examined human peritoneal macrophages are exudate and PA-negative, this suggests, in accordance with the animal model system, that a chronic sterile inflammation exists in the peritoneal cavity of CAPD patients and healthy women undergoing laparoscopy. After 2 hr culture, blood monocytes and peritoneal macrophages transformed into cells with the characteristics of exudate-resident and resident macrophages, so isolation procedures that include short periods of culture can change the developmental stage of human monocytes and macrophages.

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