Comparison of clinical efficacy of mifepristone and gestrinone in consolidation therapy after operation of endometriosis in 68 cases

Objective:To observe the clinical efficacy of mifepristone and gestrinone in consolidation therapy after operation of pelvic endometriosis.Methods:68 cases undergoing conservative surgery and diagnosed as pelvic endometriosis by pathological examination from June 2008 to June 2009 were divided into 2 groups randomly: 34 cases in mifepristone group took mifepristone,2.5 mg per day;34 cases in gestrinone group took gestrinone,12.5 mg each time,twice a week.The treatment started after one week and continued for 6 months,follow-up was carried out regularly.Results:The rates of dysmenorrhea and other painful symptoms in the two groups after treatment were significantly lower than those before treatment(P0.05),follow-up results showed that complete remission rates in mifepristone group and gestrinone group were 85.2% and 88.2%,respectively,the relapse rates in mifepristone group and gestrinone group were 5.9% and 2.9%,respectively,there was no significant difference(P 0.05).The incidence of adverse reactions in mifepristone group was significantly lower than that in gestrinone group.Conclusion:Application of mifepristone and gestrinone in consolidation therapy after operation of pelvic endometriosis is safe and effective,without severe adverse reactions.