The relationship between infertility and macrophages in the peritoneal fluid of patients with endometriosis

Macrophage is the main nucleated cell in the peritoneal fluid,and it is the first and main cell that reacts to the inflammation.In the endometriosis patients,the amount of peritoneal fluid and the concentration of macrophages are increased.Thus the cytokines secreted by macrophages in peritoneal(fluid) and serum are increased remarkably.The macrophage's ability of phagocytizing sperm may also be(increased.) Macrophages can inhibit the motility and function of sperm,change the anatomical structure of the pelvic by mediating the inflammation,affect the function of the oviduct,and induce infertility.Some cytokines secreted by macrophages could injury embryo, but others could improve the development of blastocyst.In this review,the relationship among macrophages,endometriosis and infertility was expatiated mainly with macrophages and the cytokines secreted by them.