Clinical Efficacy of Aspirin Combined with Rivaroxaban in Patients with Long-Term Implantation of Inferior Vena Cava Filter

Clinical Efficacy of Aspirin Combined with Rivaroxaban in Patients with Long-Term Implantation of Inferior Vena Cava Filter | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Clinical Efficacy of Aspirin Combined with Rivaroxaban in Patients with Long-Term Implantation of Inferior Vena Cava Filter Guoliang Wang, Peng Ji, Huagang Li, Hongzhi Sun, Lei Qi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7370992/v1 This work is licensed under a CC BY 4.0 License Status: Under Revision Version 1 posted 10 You are reading this latest preprint version Abstract Objective We sought to explore the clinical effectiveness of aspirin combined with rivaroxaban in patients with long-term inferior vena cava filters (IVCF). Methods 75 patients who had received long-term implanted IVCF in the Third People’s Hospital of Hefei and the First Hospital Affiliated with Anhui University of Traditional Chinese Medicine from August 2021 to December 2023 were selected and categorized into three groups: Group A (didn’t receive any oral treatment), B (received oral rivaroxaban postoperatively), and C received (aspirin + rivaroxaban, orally) of 25, 25, and 24 patients, respectively as one patient was excluded from group A, due to IVCF retrieval during treatment. All three groups were followed up at 1 month, 3 months, 6 months, and 12 months. Results Compared with group B, the recurrence and progression of DVT, thrombosis of IVCF, and score of Venous Clinical Severity Score (VCSS) at 12 months post-surgery were significantly higher in group A (P 0.05). The incidence of bleeding in Group C was significantly higher than in Group B (P 0.05). Conclusion Compared to the absence of anticoagulant therapy, the administration of rivaroxaban significantly reduces complications and alleviates clinical symptoms in patients with long-term IVCF implantation. However, (aspirin + rivaroxaban) did not demonstrate any additional effect compared to rivaroxaban monotherapy, and it is linked to a higher risk of bleeding. Health sciences/Cardiology Health sciences/Diseases Health sciences/Health care Health sciences/Medical research Inferior Vena Cava Filter Deep Venous Thrombosis Aspirin Rivaroxaban Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Revision Version 1 posted Editorial decision: Revision requested 07 Dec, 2025 Reviews received at journal 06 Dec, 2025 Reviewers agreed at journal 04 Dec, 2025 Reviews received at journal 10 Nov, 2025 Reviewers agreed at journal 07 Nov, 2025 Reviewers invited by journal 07 Oct, 2025 Editor assigned by journal 07 Oct, 2025 Editor invited by journal 01 Sep, 2025 Submission checks completed at journal 28 Aug, 2025 First submitted to journal 28 Aug, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7370992","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":531464981,"identity":"b1a59687-f2c1-40f7-92ae-bec3272f611b","order_by":0,"name":"Guoliang Wang","email":"","orcid":"","institution":"The Third People’s Hospital of Hefei","correspondingAuthor":false,"prefix":"","firstName":"Guoliang","middleName":"","lastName":"Wang","suffix":""},{"id":531464983,"identity":"4bcf6282-116a-485b-9691-1fd5329b0b17","order_by":1,"name":"Peng Ji","email":"","orcid":"","institution":"The Third People’s Hospital of 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Filter","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Inferior Vena Cava Filter, Deep Venous Thrombosis, Aspirin, Rivaroxaban","lastPublishedDoi":"10.21203/rs.3.rs-7370992/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7370992/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eObjective\u003c/h2\u003e\u003cp\u003eWe sought to explore the clinical effectiveness of aspirin combined with rivaroxaban in patients with long-term inferior vena cava filters (IVCF).\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e\u003cp\u003e75 patients who had received long-term implanted IVCF in the Third People\u0026rsquo;s Hospital of Hefei and the First Hospital Affiliated with Anhui University of Traditional Chinese Medicine from August 2021 to December 2023 were selected and categorized into three groups: Group A (didn\u0026rsquo;t receive any oral treatment), B (received oral rivaroxaban postoperatively), and C received (aspirin\u0026thinsp;+\u0026thinsp;rivaroxaban, orally) of 25, 25, and 24 patients, respectively as one patient was excluded from group A, due to IVCF retrieval during treatment. All three groups were followed up at 1 month, 3 months, 6 months, and 12 months.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e\u003cp\u003eCompared with group B, the recurrence and progression of DVT, thrombosis of IVCF, and score of Venous Clinical Severity Score (VCSS) at 12 months post-surgery were significantly higher in group A (P\u0026thinsp;\u0026lt;\u0026thinsp;0.05). Regarding PE, neither cases nor symptoms were reported in all groups (P\u0026thinsp;\u0026gt;\u0026thinsp;0.05). The incidence of bleeding in Group C was significantly higher than in Group B (P\u0026thinsp;\u0026lt;\u0026thinsp;0.05); however, no statistically significant difference in bleeding was observed between Groups A and B (P\u0026thinsp;\u0026gt;\u0026thinsp;0.05).\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e\u003cp\u003eCompared to the absence of anticoagulant therapy, the administration of rivaroxaban significantly reduces complications and alleviates clinical symptoms in patients with long-term IVCF implantation. However, (aspirin\u0026thinsp;+\u0026thinsp;rivaroxaban) did not demonstrate any additional effect compared to rivaroxaban monotherapy, and it is linked to a higher risk of bleeding.\u003c/p\u003e","manuscriptTitle":"Clinical Efficacy of Aspirin Combined with Rivaroxaban in Patients with Long-Term Implantation of Inferior Vena Cava Filter","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-10-20 12:49:28","doi":"10.21203/rs.3.rs-7370992/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-12-08T04:59:11+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-12-06T16:48:14+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"28467572548388913740513983529688880358","date":"2025-12-05T04:02:35+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-11-10T11:16:11+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"111093416396512550868594410736769991350","date":"2025-11-07T07:11:39+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-10-08T03:05:44+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-10-08T03:04:47+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2025-09-02T03:00:51+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-08-28T17:09:31+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scientific Reports","date":"2025-08-28T17:06:53+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"62c1fa64-09b4-4c11-b87f-ea8edceb827e","owner":[],"postedDate":"October 20th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"in-revision","subjectAreas":[{"id":56503441,"name":"Health sciences/Cardiology"},{"id":56503442,"name":"Health sciences/Diseases"},{"id":56503443,"name":"Health sciences/Health care"},{"id":56503444,"name":"Health sciences/Medical research"}],"tags":[],"updatedAt":"2025-12-08T05:08:29+00:00","versionOfRecord":[],"versionCreatedAt":"2025-10-20 12:49:28","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7370992","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7370992","identity":"rs-7370992","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}