Chromosomal polymorphisms and susceptibility to menstrual disorders: a retrospective analysis of 24,578 wemen

Abstract Purpose To evaluate the association between the polymorphic variants of chromosomes and menstrual disorders.Methods The data from our previous retrospective, single-center cohort study were re-analyzed. Women with regular menstruation were included as controls. Women with menstrual cycle abnormalities were subgrouped according to reproductive causes. Frequency of chromosomal polymorphisms were compared between groups. Regression analysis were used to adjust for potential confounding variables.Result A total of 24,578 women composing of 8,062 women with regular cycles as the control group and 16,516 women as the menstrual cycle irregularity group were included. When compared with control group, the incidence of chromosomal polymorphisms in the total menstrual cycle irregularity group, Polycystic ovary syndrome group and Primary ovarian insufficiency group were significantly higher (4.49% versus 5.34%, P = 0.004, 4.49% versus 5.35%, P = 0.018 and 4.49% versus 5.94%, P = 0.002, respectively). The incidences of inv(9) in Primary ovarian insufficiency group were significantly higher than that in the control individuals (1.0% versus 1.6%, P = 0.024). Logistic regression analysis showed an effect of chromosomal polymorphisms on menstrual cycle irregularity (OR: 1.62, 95%CI: 1.234–2.187, P = 0.007; adjusted OR: 1.46, 95%CI: 1.153–1.819, P < 0.001). The result demonstrated an effect of chromosomal polymorphisms on Primary ovarian insufficiency group (OR: 2.52, 95%CI: 1.307–5.177, P < 0.001; adjusted OR: 2.61, 95%CI: 1.371–4.605, P < 0.001).Conclusion The study suggests chromosomal polymorphisms adversely affect female menstrual cycle irregularity.