Change of Reproductive Hormone in Infertile Women with Endometriosis

To identify the role of reproductive endocrinology on infertility caused by endometriosis(EM) by detecting reproductive hormones in blood and peritoneal fluid. During follicular phase,reproductive hormones in blood and peritoneal fluid were measured by MEIA in 78 patients(32 infertile women with pelvic EM, of whom 19 cases had abnormal menstruation, 20 women with EM only and 26 infertile women with uncertain causes).The control group were 14 healthy women who underwent tubal ligation. The levels of PRL?E2 and T in blood were higher in patients with EM than in infertile women without EM and in the control group, these hormones were higher in severe cases of EM than in moderate and mild cases(P0 05); the levels of PRL and T were higher in EM patients with infertility than in those patients without infertility;the level of LH was higher in infertile women without EM than in the control group(P0 05); there was no difference in the levels of FSH and P in blood among all groups(P0 05).The levels of PRL?LH?E2 and T in peritoneal fluid were higher in infertile patients with EM than in the other groups(P0 05),but there was no difference in the levels of FSH and P between them(P0 05). The level of PRL was higher in EM patients without infertility than in infertile women without EM and in normal control, but LH was higher in infertile women without EM than in EM patients without infertility and in normal control(P0 05). There was no difference in the levels of FSH?E2 and P among these three groups(P0 05). All hor mones except FSH appeared higher in severe cases than in moderate cases, and higher in moderate than in mild cases(P0 05). [Conclusion] Endometriosis patients especially those with infertility have higher levels of PRL and T in blood and peritoneal fluid which may be one of the causes of infertility.