Efficacy of GnRH-a and gestrinone used laparoscopic endometriosis surgery

Objective To compare the effect of GnRH-a and Gestrinone applied separately laparoscopic surgery for endometriosis.Methods 100 patients EM were divided into 50 patients in each group,Ⅰ group was given GnRH-a,Ⅱgroup was given Gestrinone,compared the clinical remission rate after 6 months,relapse rate and two groups of patients before and after sex hormones FSH,LH,E2 level changes,adverse reactions.Results The complete remission rate,partial remission rate of Ⅰ group was significantly higher than that group Ⅱ(P0.05);but the recurrence rate of had no significant difference between two groups(P0.05).After treatment,FSH,LH and E2 was significantly lower than before treatment,and the Group Ⅰ lowered more obviously than Group Ⅱ(P0.05).Group Ⅰ and Ⅱ all had irregular vaginal bleeding,loss of libido,weight gain,night sweats,hot flashes,impaired liver function,the difference was not significant(P0.05).Conclusion GnRH-a and Gestrinone applied separately laparoscopic en-dometriosis surgery have no significant adverse reactions,have good security,but the efficacy of GnRH-a has more advantages than Gestrinone.