Round Cell Vaginal Malignant Melanoma: A rare entity.

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This case report describes a rare round cell vaginal malignant melanoma initially misdiagnosed as a urethral caruncle, highlighting the condition's poor prognosis and low survival rates associated with tumor size.

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Abstract

Malignant melanoma is predominantly a skin disease but in rare instances it may occur at other sites. A vaginal melanoma is a rare clinical entity and the round cell type is an uncommon variant. Although the present case was clinically diagnosed as a urethral caruncle, on histopathological examination and immunostaining it was diagnosed as a round cell pigmented malignant melanoma. The patient refused radical surgery and was given a full course radiotherapy treatment but died a year later. Malignant vaginal melanoma carries a very poor prognosis even when lesion is localised at the time of presentation. The five-year survival rate ranges from 10-20% with the prognosis being influenced by tumour size. A tumour size ≥3cm has a poor prognosis. Age, mitotic count, stage, and location of the lesion do not influence survival rates.
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europepmc
last seen: 2026-09-27T09:11:36.575535+00:00
unpaywall
last seen: 2026-08-15T06:29:46.044917+00:00
License: CC-BY-4.0