PAGE2B is a prognostic marker for colorectal adenocarcinoma: bioinformatics analysis after correction for thyroid papillary carcinoma

PAGE2B is a prognostic marker for colorectal adenocarcinoma: bioinformatics analysis after correction for thyroid papillary carcinoma | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article PAGE2B is a prognostic marker for colorectal adenocarcinoma: bioinformatics analysis after correction for thyroid papillary carcinoma Yanyan Zhang, Li Li, Huihui Zheng, Tiantian Zheng, Liping Xu, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3995492/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Globally, Colon cancer has a high incidence and mortality rate, adenocarcinoma s is the most common pathological type. In this study, our objective was to explore a new biomarker for early diagnosis and prognosis in colorectal adenocarcinoma (COAD) patients. We downloaded mRNA data related to colorectal adenocarcinoma and thyroid papillary carcinoma through The Cancer Genome Atlas (TCGA) database, and used PTC as the mediator to explore the key genes causing the adverse prognosis of COAD. Univariate and multivariate Cox regression models were used, along with clinical information from COAD patients, to analyze the prognostic value of the target gene in COAD patients. Functional enrichment analysis was subsequently performed to elucidate the molecular mechanisms underlying the regulatory effects of the target gene on colorectal adenocarcinoma. We explore whether methylation is one of the causes of the high expression of target genes. Additionally, we calculated the percentage of infiltrating immune cells in COAD patients and evaluated their correlation with target gene expression. The potential sensitive drugs of target genes were explored by drug sensitivity analysis. Compared with those normal tissue, the gene expression levels of PAGE2B were found to be elevated in Compared with those colorectal adenocarcinoma tissues. Furthermore, the expression of PAGE2B in colorectal adenocarcinoma exhibited significant correlations with M stage. The results of functional enrichment analysis suggested the potential involvement of PAGE2B in the regulation of DAN methylation and cell cycle. Additionally, there were significant correlations between the expression level of the PAGE2B gene and the infiltration of various immune cells within the colon tumor microenvironment. PAGE2B can be used as a prognostic biomarker in patients with COAD could potentially be therapeutic target for COAD. Health sciences/Biomarkers Health sciences/Oncology Colonic adenocarcinoma thyroid papillary carcinoma bioinformatics machine learning Full Text Additional Declarations No competing interests reported. Supplementary Files data.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3995492","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":279987421,"identity":"4902c160-beb6-401b-ba2c-0d944782e06d","order_by":0,"name":"Yanyan Zhang","email":"","orcid":"","institution":"The First Affiliated Hospital of Henan Polytechnic University","correspondingAuthor":false,"prefix":"","firstName":"Yanyan","middleName":"","lastName":"Zhang","suffix":""},{"id":279987422,"identity":"e75f880a-61ca-4b40-8174-192235c24c74","order_by":1,"name":"Li Li","email":"","orcid":"","institution":"The First Affiliated Hospital of Henan 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In this study, our objective was to explore a new biomarker for early diagnosis and prognosis in colorectal adenocarcinoma (COAD) patients. We downloaded mRNA data related to colorectal adenocarcinoma and thyroid papillary carcinoma through The Cancer Genome Atlas (TCGA) database, and used PTC as the mediator to explore the key genes causing the adverse prognosis of COAD. Univariate and multivariate Cox regression models were used, along with clinical information from COAD patients, to analyze the prognostic value of the target gene in COAD patients. Functional enrichment analysis was subsequently performed to elucidate the molecular mechanisms underlying the regulatory effects of the target gene on colorectal adenocarcinoma. We explore whether methylation is one of the causes of the high expression of target genes. Additionally, we calculated the percentage of infiltrating immune cells in COAD patients and evaluated their correlation with target gene expression. The potential sensitive drugs of target genes were explored by drug sensitivity analysis. Compared with those normal tissue, the gene expression levels of PAGE2B were found to be elevated in Compared with those colorectal adenocarcinoma tissues. Furthermore, the expression of PAGE2B in colorectal adenocarcinoma exhibited significant correlations with M stage. The results of functional enrichment analysis suggested the potential involvement of PAGE2B in the regulation of DAN methylation and cell cycle. Additionally, there were significant correlations between the expression level of the PAGE2B gene and the infiltration of various immune cells within the colon tumor microenvironment. 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