Clinical uses of antiprogestogens

Baird DT, DavidT. Baird, D. T. Baird
Journal of the Society for Gynecologic Investigation · 2000 · vol. 7(2) , pp. 49–52 · doi:10.1016/s1071-5576(99)00063-5 · PMID:10732330 · W2027666309
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Antiprogestogens, which inhibit progesterone synthesis or action, are used for abortion, labor induction, contraception, cervical ripening, and treating endometriosis, fibromyomata, meningiomas, Cushing syndrome, and glaucoma.

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Abstract

Progesterone is essential to the establishment and maintenance of pregnancy. Compounds that inhibit the synthesis of progesterone, or antagonize progesterone action, have multiple effects including the induction of abortion, labor induction, contraception, and cervical ripening. They also may be used in the treatment of endometriosis, fibromyomata, meningiomas, Cushing syndrome, and glaucoma. Antiprogesterone compounds will play important roles in manipulating reproductive function for fertility control and in the treatment of hormone-dependent disease. This article reviews the potential of antiprogesterone compounds.

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MeSH descriptors

Hormone Antagonists Progestins Abortion, Induced Contraceptive Agents, Female Female Genital Diseases, Female Genital Diseases, Female Hormone Antagonists Humans Labor, Induced Pregnancy Progestins

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