The influencing factors of cognitive function in breast cancer patients after treatment are assessed using the CANTAB test system and the FACT-Cog test indicators

The influencing factors of cognitive function in breast cancer patients after treatment are assessed using the CANTAB test system and the FACT-Cog test indicators | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The influencing factors of cognitive function in breast cancer patients after treatment are assessed using the CANTAB test system and the FACT-Cog test indicators Lei Zhang, Yi Wang, Xiaochen Mo, Qingyin Zhang, Xiaoling Yuan, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8130287/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objective To evaluate the role and influencing factors of the CANTAB test system and the FACT-Cog test indicators in cancer-related cognitive impairment (CRCI) among breast cancer patients after treatment, and to provide strategies for constructing personalized interventions for high-risk populations with cognitive impairment. Methods The memory, attention, and executive function of 144 breast cancer patients after treatment were assessed using seven indicators from the CANTAB system: RVP, RVPMDL, SWMBE-T, SWMBE4, SWMBE6, SEMBE8, and OTSPSFC. Correlation analyses were conducted between these seven indicators and variables including marital age, family income, FACT-Cog test indicators, fatigue scores, hormone therapy status, menopausal status, and appropriate exercise level. Results CANTAB test indicators showed no correlation with marital status, sleep scores, self-efficacy scores, or anxiety scores, but were associated with menopausal status. FACT-Cog indicators were not correlated with menopausal status or anxiety scores, but were correlated with marital status, sleep scores, and self-efficacy scores. Both systems showed consistent correlations with age, education level, family income, depression scores, fatigue scores, hormone therapy status, and appropriate exercise duration. Conclusion The CANTAB test system and the FACT-Cog test indicators play complementary roles in assessing cognitive impairment in breast cancer patients, comprehensively covering the functional assessment of cognitive impairment. Interventions aimed at improving fatigue, depression, and sleep disorders can effectively mitigate cognitive impairment in breast cancer patients after treatment. Breast cancer Cognitive impairment CANTAB FACT-Cog Moderate physical activity Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8130287","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":545956581,"identity":"47da4bb6-bff1-4b50-af4e-5777d1371ab3","order_by":0,"name":"Lei Zhang","email":"","orcid":"","institution":"Minhang Branch, Fudan University Shanghai Cancer Center","correspondingAuthor":false,"prefix":"","firstName":"Lei","middleName":"","lastName":"Zhang","suffix":""},{"id":545956582,"identity":"86e3be2c-7e5e-40c7-b9ff-6f3762e39a44","order_by":1,"name":"Yi Wang","email":"","orcid":"","institution":"Shidong Hospital of Yangpu District","correspondingAuthor":false,"prefix":"","firstName":"Yi","middleName":"","lastName":"Wang","suffix":""},{"id":545956583,"identity":"ce2e8af7-4d04-4e54-a2ac-fb8a8fece9ac","order_by":2,"name":"Xiaochen Mo","email":"","orcid":"","institution":"Minhang Branch, Fudan University Shanghai Cancer Center","correspondingAuthor":false,"prefix":"","firstName":"Xiaochen","middleName":"","lastName":"Mo","suffix":""},{"id":545956584,"identity":"f70868e2-627a-4b4c-9a7e-cfd9ed1cdef9","order_by":3,"name":"Qingyin Zhang","email":"","orcid":"","institution":"Minhang Branch, Fudan University Shanghai Cancer Center","correspondingAuthor":false,"prefix":"","firstName":"Qingyin","middleName":"","lastName":"Zhang","suffix":""},{"id":545956585,"identity":"c80f019c-411c-493e-aa18-c1bbf0747111","order_by":4,"name":"Xiaoling Yuan","email":"","orcid":"","institution":"Shanghai Jiao Tong University","correspondingAuthor":false,"prefix":"","firstName":"Xiaoling","middleName":"","lastName":"Yuan","suffix":""},{"id":545956586,"identity":"245cf552-7a3f-4f19-951e-96aa7747818f","order_by":5,"name":"Yinghua li","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA5klEQVRIiWNgGAWjYDACCQbGA4kNDAz8zAeAbBA4QFgLA1iLZFsCKVoYgVoMjhGrRX52j8GBhzvs8oyP8Rje+LmDQY7vRgLj5wI8WhjnnDE4kHgmudjsGI+xZe8ZBmPJGwnM0jPwaGGWyAFqaWNO3Ha/x0yCt40hccONBDZmHjxa2CBa6hM3t/GYSf5tY6gnqIUHouVw4gY2HjNpoC0JBoS0SEikFQC1HE+ccYyt2Fq2TcJw5pmHzdL4tMjPSN748GdbdWJ/G/PGm2/bbOT5jicf/IxPC4atQAyKplEwCkbBKBgFFAEAIQVNsCsRjm4AAAAASUVORK5CYII=","orcid":"","institution":"Shanghai Fifth People's Hospital Affiliated with Fudan University","correspondingAuthor":true,"prefix":"","firstName":"Yinghua","middleName":"","lastName":"li","suffix":""}],"badges":[],"createdAt":"2025-11-17 02:23:16","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-8130287/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8130287/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":96147394,"identity":"2adc1c30-fec1-4c16-9fb6-db371bdac395","added_by":"auto","created_at":"2025-11-18 06:47:32","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":85740,"visible":true,"origin":"","legend":"","description":"","filename":"CRCIarticle20251112F.docx","url":"https://assets-eu.researchsquare.com/files/rs-8130287/v1/f230abd5ffd6bce9e55f936b.docx"},{"id":96147398,"identity":"858623b1-fdfc-4fcc-8666-9b866a373323","added_by":"auto","created_at":"2025-11-18 06:47:32","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":56413,"visible":true,"origin":"","legend":"","description":"","filename":"CRCIarticle20251112Ftables.docx","url":"https://assets-eu.researchsquare.com/files/rs-8130287/v1/3e6eb37b49234e28eb675083.docx"},{"id":96249591,"identity":"ab4a1313-8c99-409e-a72b-5a3685a5a040","added_by":"auto","created_at":"2025-11-19 07:35:27","extension":"json","order_by":2,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":7903,"visible":true,"origin":"","legend":"","description":"","filename":"00f221889d734d61ac21983bfe7f2e7c.json","url":"https://assets-eu.researchsquare.com/files/rs-8130287/v1/6cef9632909ff08c6833cfcb.json"},{"id":96250489,"identity":"2bc05778-0688-4c1d-bd11-0c3b731cbf77","added_by":"auto","created_at":"2025-11-19 07:38:27","extension":"xml","order_by":3,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":276385,"visible":true,"origin":"","legend":"","description":"","filename":"00f221889d734d61ac21983bfe7f2e7c1enriched.xml","url":"https://assets-eu.researchsquare.com/files/rs-8130287/v1/1279bed957cd57eee8514f5b.xml"},{"id":96147393,"identity":"e8dfbfdf-6a78-4aa1-b267-99cb1d77f6fe","added_by":"auto","created_at":"2025-11-18 06:47:31","extension":"xml","order_by":4,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":272823,"visible":true,"origin":"","legend":"","description":"","filename":"00f221889d734d61ac21983bfe7f2e7c1structuring.xml","url":"https://assets-eu.researchsquare.com/files/rs-8130287/v1/035cb89e75d329f220cca02a.xml"},{"id":96147397,"identity":"5c2cdbb2-fb30-41e3-9a6f-b1341f48c459","added_by":"auto","created_at":"2025-11-18 06:47:32","extension":"html","order_by":5,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":281214,"visible":true,"origin":"","legend":"","description":"","filename":"earlyproof.html","url":"https://assets-eu.researchsquare.com/files/rs-8130287/v1/206e2de203f76c19672946be.html"},{"id":108977957,"identity":"1500d37e-b17d-417c-a67d-427e01d0519c","added_by":"auto","created_at":"2026-05-11 11:33:30","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":397193,"visible":true,"origin":"","legend":"","description":"","filename":"CRCIarticle20251112F.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8130287/v1_covered_02d48ac0-3b51-4ca9-8fbf-3e49bcff8981.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"The influencing factors of cognitive function in breast cancer patients after treatment are assessed using the CANTAB test system and the FACT-Cog test indicators","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Breast cancer, Cognitive impairment, CANTAB, FACT-Cog, Moderate physical activity","lastPublishedDoi":"10.21203/rs.3.rs-8130287/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8130287/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eObjective\u003c/h2\u003e\u003cp\u003eTo evaluate the role and influencing factors of the CANTAB test system and the FACT-Cog test indicators in cancer-related cognitive impairment (CRCI) among breast cancer patients after treatment, and to provide strategies for constructing personalized interventions for high-risk populations with cognitive impairment.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e\u003cp\u003eThe memory, attention, and executive function of 144 breast cancer patients after treatment were assessed using seven indicators from the CANTAB system: RVP, RVPMDL, SWMBE-T, SWMBE4, SWMBE6, SEMBE8, and OTSPSFC. Correlation analyses were conducted between these seven indicators and variables including marital age, family income, FACT-Cog test indicators, fatigue scores, hormone therapy status, menopausal status, and appropriate exercise level.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e\u003cp\u003eCANTAB test indicators showed no correlation with marital status, sleep scores, self-efficacy scores, or anxiety scores, but were associated with menopausal status. FACT-Cog indicators were not correlated with menopausal status or anxiety scores, but were correlated with marital status, sleep scores, and self-efficacy scores. Both systems showed consistent correlations with age, education level, family income, depression scores, fatigue scores, hormone therapy status, and appropriate exercise duration.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e\u003cp\u003eThe CANTAB test system and the FACT-Cog test indicators play complementary roles in assessing cognitive impairment in breast cancer patients, comprehensively covering the functional assessment of cognitive impairment. Interventions aimed at improving fatigue, depression, and sleep disorders can effectively mitigate cognitive impairment in breast cancer patients after treatment.\u003c/p\u003e","manuscriptTitle":"The influencing factors of cognitive function in breast cancer patients after treatment are assessed using the CANTAB test system and the FACT-Cog test indicators","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-18 06:47:25","doi":"10.21203/rs.3.rs-8130287/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"0549a56e-3674-48dc-8608-a027640799c6","owner":[],"postedDate":"November 18th, 2025","published":true,"recentEditorialEvents":[{"type":"decision","content":"Rejected","date":"2026-05-11T00:27:25+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-07T11:28:26+00:00","index":34,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-05T07:31:11+00:00","index":33,"fulltext":""}],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-05-11T00:39:38+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-18 06:47:25","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8130287","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8130287","identity":"rs-8130287","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}