Two cases of successful pregnancy with in vitro fertilization after laparoscopic surgery following repeated unsuccessful in vitro fertilization

Akiko Kawasaki, Kanako Abe, Naoki Kita, Tomoko Tanaka, Kazunari Kondo, Yoko Ainoya, Atsushi Wada, Takatoshi Kondo, Yukiko Hara, Naoko Edamoto, Hajime Okamoto
In: JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY · 2009 · vol. 25(1) , pp. 236–239 · doi:10.5180/jsgoe.25.236 · W2329604016
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-04 ⓘ

Laparoscopic surgery for mild endometriosis improved IVF success rates in two women with repeated implantation failures.

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This 2009 case report describes two women with functional infertility who experienced repeated unsuccessful IVF-ET or frozen-thawed embryo transfers despite transfer of good-quality embryos. In both cases, the authors performed diagnostic/laparoscopic surgery and treated mild endometriosis, after which each patient achieved pregnancy on a subsequent IVF-ET attempt about 2 months later (one resulted in miscarriage after an earlier post-surgery trial, while the other achieved pregnancy after the next frozen-thawed transfer). The main limitation is that the evidence is based on only two cases, without a control group, so causality and generalizability cannot be established. This paper is centrally about endometriosis — it reports successful pregnancies after laparoscopic detection and treatment of mild endometriosis following repeated IVF failures.

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Abstract

We performed laparoscopic surgery for two women after repeated failure of in vitro fertilization with intent to increase the possibility of pregnancy. First case was a 32-year-old woman with functional infertility. She underwent diagnostic laparoscopy and mild endometriosis was detected. She became pregnant with her second IVF-ET trial after the surgery, but miscarried. She failed to become pregnant with following 5 trials of IVF-ET although good quality embryos were transferred in all trials. We performed laparoscopic surgery and treated her for mild endometriosis. She became pregnant with the next IVF-ET 2 months after the surgery. The other case was a 34-year-old woman with functional infertility. She underwent embryo transfer 4 times including 2 frozen-embryo-thawed transfers. She could not become pregnant even though good quality embryos were transferred in all trials. We performed laparoscopic surgery and treated her for mild endometriosis. She finally became pregnant with the next frozen-thawed-embryo transfer 2 months after the surgery. IVF-ET is regarded as the final treatment for infertility. But even after repeated failure of IVF-ET, laparoscopic surgery will able to be an effective treatment for some patients with functional infertility.
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Case report Two cases of successful pregnancy with in vitro fertilization after laparoscopic surgery following repeated unsuccessful in vitro fertilization 2009 Volume 25 Issue 1 Pages 236-239 Details Abstract We performed laparoscopic surgery for two women after repeated failure of in vitro fertilization with intent to increase the possibility of pregnancy. First case was a 32-year-old woman with functional infertility. She underwent diagnostic laparoscopy and mild endometriosis was detected. She became pregnant with her second IVF-ET trial after the surgery, but miscarried. She failed to become pregnant with following 5 trials of IVF-ET although good quality embryos were transferred in all trials. We performed laparoscopic surgery and treated her for mild endometriosis. She became pregnant with the next IVF-ET 2 months after the surgery. The other case was a 34-year-old woman with functional infertility. She underwent embryo transfer 4 times including 2 frozen-embryo-thawed transfers. She could not become pregnant even though good quality embryos were transferred in all trials. We performed laparoscopic surgery and treated her for mild endometriosis. She finally became pregnant with the next frozen-thawed-embryo transfer 2 months after the surgery. IVF-ET is regarded as the final treatment for infertility. But even after repeated failure of IVF-ET, laparoscopic surgery will able to be an effective treatment for some patients with functional infertility. © 2009 Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy Favorites & Alerts Recently viewed articles

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