Chemerin as a Diagnostic Marker for Fmf in Egyptian Patients

Abstract Familial Mediterranean fever (FMF) is the most common autoinflammatory disorder characterized by chronic subclinical inflammation. The aim of the work is to access if chemerin can be used as a diagnostic index in FMF patients. Methods: A total of 66 FMF patients and 60 controls matching age and sex were enrolled in the study. Serum chemerin, lipid profile and vitamin D were determined by ELISA assay. Results: Chemerin level which suggested chronic inflammation was significantly elevated as compared to the controls. The FMF patients had highly significant levels of total cholesterol, total triglycerides and LDL, while the HDL significantly inversely correlated in the FMF patients compared to controls. Moreover, the vitamin D level was significantly lower in FMF patients. Conclusion: chemerin that acts as a pro-inflammatory adipokine, could be used as a biomarker reflecting the chronic pro-inflammatory status in the FMF patients. Vitamin D supplementation is recommended in the FMF patients.