Clinical effect of GnRH-α in treatment of patients with endometriosis after laparoscope surgery

In: Zhongguo jiceng yiyao · 2012 · vol. 19(04) , pp. 495–496 · doi:10.3760/cma.j.issn.1008-6706.2012.04.008 · W3032092802
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In 185 post-surgical endometriosis patients, GnRH-α treatment yielded higher symptom improvement and pregnancy rates with lower recurrence compared to gastrinone over a 24-month follow-up.

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Abstract

Objective To study the clinical effect of GnRH-α in treatment of patients with endometriosis after laparoscope surgery.Methods 185 endometriosis patients who got laparoscope surgery were randomly divided into the observation group(93 cases) and the control group(92 cases),and took GnRH-α and gastrinone,respectively.After 24 months follow-up,the outcomes of pelvic cavity symptom improvement,recurrence and pregnancy were observed.Results After treatment,the pelvic cavity symptom improvement (87.1% ) and pregnancy rate (79.3 % ) in the observation group was higher than those of the control group(70.7%,52.4% ) (x2 =7.517,4.059,all P <0.05),and the recurrence rate( 19.4% ) in the observation group was lower than that of the control group(34.8% )(x2 =5.581,P <0.05).Conclusion The treatment of endometriosis with GnRH-α combined with laparoscope surgery could attain desirable effect.Compared with gastrinone,it could effectively improve pelvic cavity symptom,decrease recurrence and increase the rate of pregnancy. Key words: Laparoscope; GnRH-α; Endometriosis

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endometriosis

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