Correlation between morphology and immunohistochemical expressions and prognosis in clear cell carcinoma of ovary

Objective To study the features of pathologic morphology and the expressions of p53,cyclin E,CD44_(V6)in clear cell carcinoma,and their relationship with patients' survival.Methods Twenty-four patients with clear cell carcinoma of ovary (CCCO)were studied by clinical data analysis,pathologic morphology and p53,CyclinE,CD44_(V6)of immunohistochemical staining.The follow-up information was also analyzed.Results Among the 24 patients with CCCO the 5-year survival rate was 49.24%.The prognosis of patients in stage Ⅰ and Ⅱ was better than that of patients in stage Ⅲ(P0.001).The prognosis of tumor size12 cm was better than that of tumor size12 cm(P=0.023).The prognosis of CCCO with endometriosis was better than that of CCCO without endometriosis(P=0.009).Two of the nine(22%)patients with predominant clear cells died and ten of the fifteen patients(66%) with hobnail cells and mixed clear-hobnail cells died.There was significant diffirenee between the two groups in survival time(P= 0.05),but not between the patieuts with and without the expression of p53(P=0.885).All the twenty-four cases of CCCO expressed cyclin E.There was significant difference in prognosis between the patients with and without expression of CD44_(V6),The prognosis of patients with positive CD44_(V6)was worse than that of patients with negative CD44_(V6).(P=0.001).Conclusions The worse prognosis in patients with CCCO is correlated with tumor size,presence of endometriosis and the hobnail tumor cell type.There is no prognostic significance for expression of p53.Cyclin E is a better marker for pathologic diagnosis of CCCO.The expression of CD44_(V6) correlates with survival and prognosis.