Utilization of Pelvic Ultrasonography and CA125 Level to Diagnose Uterine Myoma and Adenomyosis

Nadia Khairy Fathi Abou Elela, Mohamed Mohamed Abd Alsalam Suliman, Dina Mohamed Gamal Eldin Soliman, Sara Atef Zaki, Ragab Alsayed Amin Ibrahim, Mostafa Gamal Abdelhaleem Mohammed
In: The Egyptian Journal of Hospital Medicine · 2022 · vol. 88(1) , pp. 3206–3212 · doi:10.21608/ejhm.2022.246932 · W4283769198
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Transvaginal ultrasonography accurately detected uterine myoma (100%), while CA125 was more specific (77%) and sensitive (87.5%) for adenomyosis, with combined use improving adenomyosis detection accuracy.

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Abstract

Background: Preoperative diagnosis of adenomyosis and uterine myoma can be aided by pelvic ultrasonography and cancer antigen 125 (CA125). Objective: This study aimed to evaluate the usefulness of CA125 level and transvaginal ultrasonography in diagnosis of uterine myoma and adenomyosis and to differentiate both lesion. Patients and Methods: One hundred patients complaining of abnormal uterine bleeding were included in this study. They were attending the Obstetrics and Gynecology Departments at Zagazig University Hospitals and Al-Ahrar Teaching Hospital for hysterectomy. Transvaginal ultrasonography (TVS) was done for all selected cases to examine the pelvis for detecting any pathology. CA 125 level was measured. Hysterectomy specimens were histopathologically examined. Results: The combination of serum CA125 level and TVS showed that it was useful in adenomyosis group as CA125 level increased the accuracy of TVS from 77% to 80.2%, while in myoma group the combination was not useful as CA 125 decreased the accuracy of TVS from 100% to 83.3%. Conclusion: Transvaginal ultrasonography is the most sensitive for myoma (100%) & CA125 level is the most specific (77%) for adenomyosis. CA125 level had the highest sensitivity (87.5%) for adenomyosis than transvaginal ultrasonography (80.1%). Combining both TVS and CA125 level increased the accuracy for detection of adenomyosis to 80.2% but decreased it to 83.3% in detection of uterine myoma.

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adenomyosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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