Post-Bragg Peak keV-Secondary Electron Radiolysis Revealed by Track-Ends Imaging of High-Energy Protons.

Post-Bragg Peak keV-Secondary Electron Radiolysis Revealed by Track-Ends Imaging of High-Energy Protons. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Post-Bragg Peak keV-Secondary Electron Radiolysis Revealed by Track-Ends Imaging of High-Energy Protons. Julien Audouin, Petter Hofverberg, Yvette Ngono-Ravache, Laurent Desorgher, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-2752706/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 19 Sep, 2023 Read the published version in Scientific Reports → Version 1 posted 12 You are reading this latest preprint version Abstract Upstream of the efficiency of proton or carbon ion beams in cancer therapy, and to optimize hadrontherapy results, we analysed the chemistry of Fricke solutions in track-end of 64-MeV protons and 1.14-GeV carbon ions. An original optical setup is designed to determine the primary track-segment yields along the last millimetres of the ion track with a sub-millimetre resolution. The Fe 3+ -yield falls in the Bragg peak to (4.9±0.4)×10 -7 mol/J and 1.9×10 -7 mol/J, under protons and carbon ions respectively. Beyond the proton Bragg peak, a yield recovery is observed over 1 mm. It is attributed to the proton beam straggling. Since a dose rate effect is ruled out in this region, keV secondary electrons are hypothesized to produce this intermediate LET effect. They might also provide DNA lesions during proton exposure, potentially at the origin of delayed radio-induced carcinogenesis. Health sciences/Oncology/Cancer/Cancer therapy/Radiotherapy Physical sciences/Chemistry/Physical chemistry/Energy transfer Physical sciences/Chemistry/Physical chemistry/Kinetics and dynamics Physical sciences/Chemistry/Physical chemistry/Spectroscopy/Spectrophotometry Physical sciences/Optics and photonics/Optical techniques/Imaging and sensing Water radiolysis high LET primary track-segment yield Bragg peak proton track carbon track Fricke solution real time absorption spectroscopy sub-millimetre resolution imaging Hadrontherapy Full Text Additional Declarations No competing interests reported. Supplementary Files ScientificReportsSI.docx Cite Share Download PDF Status: Published Journal Publication published 19 Sep, 2023 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Major revision 16 Aug, 2023 Reviews received at journal 14 Aug, 2023 Reviewers agreed at journal 04 Aug, 2023 Reviewers agreed at journal 21 Jul, 2023 Reviews received at journal 18 Apr, 2023 Reviewers agreed at journal 14 Apr, 2023 Reviewers agreed at journal 13 Apr, 2023 Reviewers invited by journal 11 Apr, 2023 Editor assigned by journal 11 Apr, 2023 Editor invited by journal 04 Apr, 2023 Submission checks completed at journal 04 Apr, 2023 First submitted to journal 29 Mar, 2023 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-2752706","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":189098592,"identity":"dcd12aea-bd3c-4e47-8e9f-24bb8bdcc73f","order_by":0,"name":"Julien Audouin","email":"","orcid":"","institution":"CEA Paris Saclay","correspondingAuthor":false,"prefix":"","firstName":"Julien","middleName":"","lastName":"Audouin","suffix":""},{"id":189098593,"identity":"d996931a-8556-48a6-b673-f70946afd2b8","order_by":1,"name":"Petter Hofverberg","email":"","orcid":"","institution":"Centre Antoine 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