A possible involvement of adrenaline in the facilitation of lordosis behavior in the ovariectomized rat

Masahiro Yanase, M Yanase
Endocrinologia japonica · 1977 · vol. 24(5) , pp. 507–512 · doi:10.1507/endocrj1954.24.507 · PMID:590202 · W2048798823
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In ovariectomized rats, adrenaline pretreatment with estradiol benzoate enhanced lordosis behavior induced by progesterone, indicating that adrenaline modifies estrogen sensitivity in the brain to facilitate this reproductive response.

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This 1977 study investigated the role of adrenaline in modulating lordosis behavior within ovariectomized rats treated with estradiol benzoate. The researchers found that administering adrenaline alongside estrogen significantly enhanced the lordosis quotient compared to estrogen treatment alone, an effect not observed with noradrenaline. The paper notes that this facilitation required simultaneous pretreatment with both hormones, suggesting that adrenaline alters brain sensitivity to estrogen. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

In order to examine a possible role of adrenaline (AD) or noradrenaline (NA) in the control of lordosis behavior, lordosis quotient (LQ) was observed daily for 8 consecutive days in the ovariectomized rat given daily 1 or 2 microgram/0.1 ml oil of estradiol benzoate (EB) alone or together with 100 microgram/0.1 ml saline of AD or NA. AD but not NA treated together with EB caused a greater change in the daily LQ than the same dose of EB alone and the change in the daily LQ by daily treatment with both 1 microgram EB and 100 microgram AD was equivalent to that by daily treatment with 2 microgram EB alone. A half mg progesterone (P) could induce the lordosis behavior in the ovariectomized rat treated 48 hr prior with both 1 microgram EB and 50 or 100 microgram AD, but not in the one treated with 1 microgram EB alone. While 50, 100 or 200 microgram NA or 10 microgram AD had no effect, 50 or 100 microgram AD pretreated together with 2 microgram EB produced a markedly higher LQ after P than 2 microgram EB alone in the ovariectomized rat. This effect of AD on the induction of lordosis behavior was produced only when AD was pretreated simultaneously with EB and AD priming 24 or 43 hr after EB failed to elicit the effect. Therefore, it is suggested that a change of the brain target site in the estrogen sensitivity produced by AD plays a part in the control of lordosis behavior.
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A Possible Involvement of Adrenaline in the Facilitation of Lordosis Behavior in the Ovariectomized Rat 1977 Volume 24 Issue 5 Pages 507-512 Details Abstract In order to examine a possible role of adrenaline (AD) or noradrenaline (NA) in the control of lordosis behavior, lordosis quotient (LQ) was observed daily for 8 consecutive days in the ovariectomized rat given daily 1 or 2μg/0.1ml oil of estradiol benzoate (EB) alone or together with 100μg/0.1ml saline of AD or NA. AD but not NA treated together with EB caused a greater change in the daily LQ than the same dose of EB alone and the change in the daily LQ by daily treatment with both 1μg EB and 100μg AD was equivalent to that by daily treatment with 2μg EB alone. A half mg progesterone (P) could induce the lordosis behavior in the ovariectomized rat treated 48 hr prior with both 1μg EB and 50 or 100μg AD, but not in the one treated with 1μg EB alone. While 50, 100 or 200μg NA or 10μg AD had no effect, 50 or 100 pg AD pretreated together with 2 pg EB produced a markedly higher LQ after p than 2μg EB alone in the ovariectomized rat. This effect of AD on the induction of lordosis behavior was produced only when AD was pretreated simultaneously with EB and AD priming 24 or 43 hr after EB failed to elicit the effect. Therefore, it is suggested that a change of the brain target site in the estrogen sensitivity produced by AD plays a part in the control of lordosis behavior. © The Japan Endocrine Society Favorites & Alerts Recently viewed articles Successor

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MeSH descriptors

Castration Epinephrine Posture Sexual Behavior, Animal Animals Epinephrine Epinephrine Estradiol Estradiol Female Norepinephrine Norepinephrine Norepinephrine Progesterone Progesterone Rats Sexual Behavior, Animal

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