Vitamin D: the tricky hormone.

<!-- Brazil - Vitamin D: the tricky hormone Vitamin D: the tricky hormone window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-MKLVK7B5B6'); (function() { function getCookie(name) { const cookieName = encodeURIComponent(name) + "="; const cookies = document.cookie ? document.cookie.split("; ") : []; const cookie = cookies.find(function(item) { return item.indexOf(cookieName) === 0; }); return cookie ? decodeURIComponent(cookie.substring(cookieName.length)) : null; } function getStoredValue(storage, legacyStorage) { const cookieValue = getCookie(storage); if (cookieValue !== null) return cookieValue; return legacyStorage && sessionStorage.getItem(legacyStorage) ? sessionStorage.getItem(legacyStorage) : null; } const fontSize = parseFloat(getStoredValue("scieloAccessibilityFontSize", "fontSizeState")); if (!Number.isNaN(fontSize) && fontSize !== 100) { const htmlFontSize = parseFloat( getComputedStyle(document.documentElement).getPropertyValue("font-size") ); document.documentElement.style.fontSize = (fontSize / 100) * htmlFontSize + "px"; } document.body.classList.toggle( "contrast", getStoredValue("scieloAccessibilityContrast", "contrastState") === "true" ); document.body.classList.toggle( "scielo__theme--dark", getStoredValue("scieloAccessibilityDarkMode", "darkState") === "true" ); document.body.classList.toggle( "accessibility_readingLine", getStoredValue("scieloAccessibilityReadingLine") === "true" ); document.body.classList.toggle( "accessibility_markerLine", getStoredValue("scieloAccessibilityMarkerLine") === "true" ); })(); .articleTxt{ top: -16px; } .scielo__border-top{ border-top: 1px solid #ccc !important; } @media (max-width: 575.98px) { .articleCtt > .container{ padding-left: 0; padding-right: 0; } .articleCtt .articleTxt{ padding-left: 16px !important; padding-right: 16px !important; } } @media (min-width: 768px){ .scielo__truncate{ display: block; max-width: 285px; } } menu Menu Brazil Journal list by title Journal list by subject area Search Metrics (abre em nova aba) Sobre o SciELO Brazil Contacts Report error SciELO.org - The SciELO Network (abre em nova aba) National and thematic collections (abre em nova aba) Journal list by title (abre em nova aba) Journal list by subject (abre em nova aba) Search (abre em nova aba) Metrics (abre em nova aba) OAI and RSS (abre em nova aba) About the SciELO Network (abre em nova aba) Contacts (abre em nova aba) Blog SciELO in Perspective (abre em nova aba) document.addEventListener('DOMContentLoaded', function () { const wrapper = document.getElementById('scieloMainMenu'); const toggle = document.getElementById('scieloMainMenuToggle'); const panel = document.getElementById('scieloMainMenuNav2'); if (!wrapper || !toggle || !panel) return; const icon = toggle.querySelector('.material-icons-outlined'); const focusableSelector = [ 'a[href]', 'button:not([disabled])', 'input:not([disabled])', 'select:not([disabled])', 'textarea:not([disabled])', '[tabindex]:not([tabindex="-1"])' ].join(','); function setIcon(iconName) { if (icon) { icon.textContent = iconName; } } function getFocusableItems() { return Array.prototype.slice.call(panel.querySelectorAll(focusableSelector)) .filter(function (item) { return item.offsetParent !== null; }); } function openMenu() { panel.hidden = false; toggle.setAttribute('aria-expanded', 'true'); wrapper.classList.add('is-open'); setIcon('close'); const focusableItems = getFocusableItems(); if (focusableItems.length) { focusableItems[0].focus(); } } function closeMenu(options) { const settings = options || {}; panel.hidden = true; toggle.setAttribute('aria-expanded', 'false'); wrapper.classList.remove('is-open'); setIcon('menu'); if (settings.restoreFocus) { toggle.focus(); } } function isMenuOpen() { return toggle.getAttribute('aria-expanded') === 'true'; } toggle.addEventListener('click', function (event) { event.preventDefault(); event.stopPropagation(); if (isMenuOpen()) { closeMenu({ restoreFocus: true }); } else { openMenu(); } }); panel.addEventListener('click', function (event) { event.stopPropagation(); }); document.addEventListener('click', function (event) { if (isMenuOpen() && !wrapper.contains(event.target)) { closeMenu(); } }); document.addEventListener('keydown', function (event) { if (!isMenuOpen()) return; if (event.key === 'Escape') { event.preventDefault(); closeMenu({ restoreFocus: true }); return; } if (event.key !== 'Tab') return; const focusableItems = getFocusableItems(); if (!focusableItems.length) return; const firstItem = focusableItems[0]; const lastItem = focusableItems[focusableItems.length - 1]; if (event.shiftKey && document.activeElement === firstItem) { event.preventDefault(); toggle.focus(); return; } if (!event.shiftKey && document.activeElement === toggle) { event.preventDefault(); firstItem.focus(); return; } if (!event.shiftKey && document.activeElement === lastItem) { closeMenu(); } }); }); Brazil language en English Português Español Archives of Endocrinology and Metabolism Mostrar opções launch Submission of manuscripts info About the journal help_outline Editorial Policy people Editorial Board help_outline Instructions to authors email Contact show_chart Metrics home Table of contents navigate_before previous current next navigate_next Text (EN) Text (English) PDF Download PDF (English) article Conteúdo: Text (EN) Text (English) Download PDF (English) (abre em nova aba) share Whatsapp BlueSky Mastodon Facebook Mais home Table of contents share Whatsapp BlueSky Mastodon Facebook Mais Text (EN) Text (English) PDF Download PDF (English) (abre em nova aba) editorial • Arch. Endocrinol. Metab. 61 (1) • Jan-Feb 2017 • https://doi.org/10.1590/2359-3997000000250 link copy Vitamin D: the tricky hormone Authorship SCIMAGO INSTITUTIONS RANKINGS In this issue of The Archives of Endocrinology and Metabolism two papers investigated the impact of vitamin D in two different health conditions: one showed a negative result investigating the association of vitamin D levels with infertility and the other one the positive effect of vitamin D supplementation in the physiological lung function. Vitamin D, a pre-hormone produced in the skin under sunlight exposure, undergoes various metabolic steps until its active form, 1,25-dihydroxyvitamin D3, is formed. The intermediary form, 25-hydroxyvitamin D (25OHD), is the recommended form for monitoring vitamin D status. The presence of 1α-hydroxylase (CYP27B1) and the vitamin D receptor (VDR) in many cells indicates a possible local ability to synthesize 1,25-dihydroxyvitamin D3, the active metabolite of vitamin D, which has turned the attention of the medical community to the noncalcemic effects of vitamin D ( 1 ). In recent decades, several studies have demonstrated the association of circulating 25OHD levels with different diseases, their activity, and health conditions. A positive association was found in several disorders such as systemic lupus erythematosus (SLE) and its activity ( 2 ); chronic obstructive pulmonary disease (COPD) ( 3 ); inflammatory bowel disease (IBD) ( 4 ); systemic sclerosis; endocrine disorders; cancer; immune; cardiovascular and other chronic diseases ( 1 , 5 ); despite the presence of numerous positive observational studies, causation studies are lacking. A few good-quality randomized controlled studies on vitamin D supplementation in diverse disease endpoints show a modest effect on blood pressure, glycemic control, cancer, and immune response ( 5 , 6 ). Hypovitaminosis D is highly frequent worldwide and in Brazil, the prevalence ranges from 16% to 80% depending on the latitude and the population studied ( 1 , 7 ). Although low levels of vitamin D are present in different diseases, infertile women studied in the article by Lopes and cols. ( 8 ) and also by others ( 9 ) did not show lower levels compared to controls. The literature in the field is ambiguous, showing both the importance of its adequate level and the lack of effect in infertility issues, such as polycystic ovary syndrome, endometriosis, myoma-induced infertility, male infertility, premature ovary failure and in vitro fertilization techniques ( 10 , 11 ). Interestingly, however, Lopes and cols. ( 8 ) pointed out the high prevalence of hypovitaminosis D in a young premenopausal population, which is in agreement with the low vitamin D levels described for postmenopausal and older women in Brazil. Vitamin D and its level of impact on fertility is a matter to be defined. This controversy points out the wide effect of vitamin D and the need for a better understanding of its metabolism. Nolasco and cols. ( 12 ) showed a positive effect of vitamin D on pulmonary function in healthy postmenopausal women participating in an aquatic exercise program. Low vitamin D levels were previously described in pulmonary diseases as well as their impact in the beginning and disease progression ( 13 ). However, studies examining the effect of vitamin supplementation on pulmonary diseases have shown diverse results. The response to tuberculosis treatment with and without vitamin D was not different ( 14 , 15 ). Even though low vitamin D levels was associated with impaired lung function and to an inadequate response to treatment in patients with asthma, the addition of vitamin D did not modify the progression of the disease, compared to controls ( 16 , 17 ). The study published in this issue, showing improvement in pulmonary function with vitamin D, confirms once again the controversy around vitamin D. The controversy could be explained by diverse factors such as the lack of assessment of long-term, overall vitamin D intake as a dietary source, or a long-term evaluation of vitamin D levels; the sometimes unavailable measurement of inactive and active metabolites; the complexity of vitamin D metabolism and the variation of the methodology of measurement; and the high inter-individual variability in vitamin distribution between carrier proteins and target receptors ( 18 ). Many trials are ongoing in an attempt to clarify the impact of vitamin D in different physiological or medical aspects. Whether or not they succeed is a matter of debate due to the variability of protocols. Considering all these aspects, we can give Vitamin D the title “The Tricky Hormone”, as the medical community is challenged to clarify the real impact of this complex hormone. REFERENCES 1 Maeda SS, Borba VZ, Camargo MB, Silva DM, Borges JL, Bandeira F, et al.; Brazilian Society of Endocrinology and Metabology (SBEM). Recommendations of the Brazilian Society of Endocrinology and Metabology (SBEM) for the diagnosis and treatment of hypovitaminosis D. Arq Bras Endocrinol Metabol. 2014;58(5):411-33. 2 Borba VZ, Vieira JG, Kasamatsu T, Radominski SC, Sato EI, Lazaretti-Castro M. Vitamin D deficiency in patients with active systemic lupus erythematosus. Osteoporos Int. 2009;20(3):427-33. 3 Franco CB, Paz-Filho G, Gomes PE, Nascimento VB, Kulak CA, Boguszewski CL, et al. Chronic obstructive pulmonary disease is associated with osteoporosis and low levels of vitamin D. Osteoporos Int. 2009;20(11):1881-7. 4 Souza HN, Lora FL, Kulak CA, Mañas NC, Amarante HM, Borba VZ. [Low levels of 25-hydroxyvitamin D (25OHD) in patients with inflammatory bowel disease and its correlation with bone mineral density]. Arq Bras Endocrinol Metabol. 2008;52(4):684-91. 5 Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012;33(3):456-92. 6 Forouhi NG, Menon RK, Sharp SJ, Mannan N, Timms PM, Martineau AR, et al. Effects of vitamin D2 or D3 supplementation on glycaemic control and cardiometabolic risk among people at risk of type 2 diabetes: results of a randomized double-blind placebo-controlled trial. Diabetes Obes Metab. 2016;18(4):392-400. 7 Arantes HP, Kulak CA, Fernandes CE, Zerbini C, Bandeira F, Barbosa IC, et al. Correlation between 25-hydroxyvitamin D levels and latitude in Brazilian postmenopausal women: from the Arzoxifene Generations Trial. Osteoporos Int. 2013;24(10):2707-12. 8 Lopes VM, Lopes JR, Brasileiro JP, Oliveira I, Lacerda RP, Andrade MR, et al. Highly prevalence of vitamin D deficiency among Brazilian women of reproductive age. Arch Endocrinol Metab. 2017;61(1):21-7. 9 Abadia L, Gaskins AJ, Chiu YH, Williams PL, Keller M, Wright DL, et al.; Environment and Reproductive Health Study Team. Serum 25-hydroxyvitamin D concentrations and treatment outcomes of women undergoing assisted reproduction. Am J Clin Nutr. 2016;104(3):729-35. 10 Dabrowski FA, Grzechocinska B, Wielgos M. The role of vitamin D in reproductive health--a Trojan Horse or the Golden Fleece? Nutrients. 2015;7(6):4139-53. 11 Skowrońska P, Pastuszek E, Kuczyński W, Jaszczoł M, Kuć P, Jakiel G, et al. The role of vitamin D in reproductive dysfunction in women – a systematic review. Ann Agric Environ Med. 2016;23(4):671-6. 12 Nolasco R, Moreira LD, Bocalini DS, Fronza FC, Marin RV, Lazaretti-Castro M. Effects of vitamin D supplementation on pulmonary function in postmenopausal women following an aquatic exercise program. Arch Endocrinol Metab. 2017;61(1):28-35. 13 Hejazi ME, Modarresi-Ghazani F, Entezari-Maleki T. A review of Vitamin D effects on common respiratory diseases: asthma, chronic obstructive pulmonary disease, and tuberculosis. J Res Pharm Pract. 2016;5(1):7-15. 14 Tukvadze N, Sanikidze E, Kipiani M, Hebbar G, Easley KA, Shenvi N, et al. High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial. Am J Clin Nutr. 2015;102(5):1059-69. 15 Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, Claxton AP, et al. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double blind randomized controlled trial. Lancet. 2011;377(9761):242-50. 16 Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, et al.; National Heart, Lung, and Blood Institute’s AsthmaNet. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014;311(20):2083-91. 17 Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med. 2010;181(7):699-704. 18 Musteata FM. Making sense of vitamin D concentrations. Future Sci OA. 2016;2(1):FSO90. Publication Dates Publication in this collection Jan-Feb 2017 History Received 25 Jan 2017 Accepted 25 Jan 2017 This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Authorship .author-card { border-bottom: 1px solid #ccc; padding: 1rem 0; } .author-card:last-child { border-bottom: 0px; } .author-name { font-weight: 600; } .orcid-button { padding-left: 2.5rem; } .modal-body { padding-bottom: 3rem; } .orcid-button::before { content: ""; position: absolute; background-image: url(https://ds.scielo.org/img/logo-orcid.svg); background-repeat: no-repeat; background-size: 1.5em auto; background-position: .5em center; display: block; width: 60px; height: 60px; top: -10px; left: 0; } person Victória Zeghbi Cochenski Borba school Department of Internal Medicine, Universidade Federal do Paraná (UFPR); Serviço de Endocrinologia e Metabologia do Hospital de Clínicas da Universidade Federal do Paraná (SEMPR) Universidade Federal do Paraná Brasil Brasil Department of Internal Medicine, Universidade Federal do Paraná (UFPR); Serviço de Endocrinologia e Metabologia do Hospital de Clínicas da Universidade Federal do Paraná (SEMPR) Correspondence to: Victória Zeghbi Cochenski Borba. Av. Agostinho Leão Junior, 285. 80030-110 – Curitiba, PR, Brasil. [email protected] Disclosure: no potential conflict of interest relevant to this article was reported. SCIMAGO INSTITUTIONS RANKINGS Department of Internal Medicine, Universidade Federal do Paraná (UFPR); Serviço de Endocrinologia e Metabologia do Hospital de Clínicas da Universidade Federal do Paraná (SEMPR) Universidade Federal do Paraná Brasil Brasil Department of Internal Medicine, Universidade Federal do Paraná (UFPR); Serviço de Endocrinologia e Metabologia do Hospital de Clínicas da Universidade Federal do Paraná (SEMPR) How to cite link copy function currentDate() { var today = new Date(); var months = ['January', 'February', 'March', 'April', 'May', 'June', 'July', 'August', 'September', 'October', 'November', 'December'] today.setTime(today.getTime()); return today.getDate() + " " + months[today.getMonth()] + " " + today.getFullYear(); } var citation = 'Borba, Victória Zeghbi Cochenski. Vitamin D: the tricky hormone. Archives of Endocrinology and Metabolism [online]. 2017, v. 61, n. 1 [Accessed CURRENTDATE], pp. 5-6. Available from: . ISSN 2359-4292. https://doi.org/10.1590/2359-3997000000250.'.replace('CURRENTDATE', currentDate()); document.getElementById('citation').innerHTML = citation; document.getElementById('citationCut').value = citation.replace('<', ' "); more_horiz Ferramentas do artigo file_download PDFs show_chart Metrics image Figuras e tabelas translate Versions and translations link How to cite this article article Related articles location_on Sociedade Brasileira de Endocrinologia e Metabologia Rua Botucatu, 572 - Conjuntos 81/83, CEP: 04023-061 , Tel: +55 (11) 5575-0311 / +55 (11) 9 9768-6933 - São Paulo - SP - Brazil E-mail: [email protected] rss_feed Stay informed of issues for this journal through your RSS reader PDF version for download PDF English Related articles Lista de links para artigos relacionados. Os links abrem em nova aba. Google (abre em nova aba) Google Scholar (abre em nova aba) Versões e tradução automática Escolha a versão original do texto ou utilize um serviço de tradução automática. Versão original do texto English Tradução automática Google Translator (abre serviço externo de tradução) Microsoft Translator (abre serviço externo de tradução) pre { display: block; padding: 9.5px; margin: 0 0 10px; font-size: 11px; line-height: 1; word-break: break-all; word-wrap: break-word; background-color: #f5f5f5; border: 1px solid #ccc; border-radius: 4px; white-space: pre-wrap; word-break: break-word; } Como citar Escolha um formato para exportar ou selecione um estilo de citação. O conteúdo abaixo pode ser atualizado após a seleção. Baixar em RIS Baixar em BIBTEX Outros formatos de citação e exportação: Enter references manager format or citation style (e.g., "APA", "AMA", "MLA", "Vancouver") vertical_align_top Go to top // Mostrar o botão ao rolar const btnTop = document.getElementById("btnTop"); window.addEventListener("scroll", () => { if (window.scrollY > 200) { btnTop.style.display = "block"; } else { btnTop.style.display = "none"; } }); // Rolar suavemente até o topo ao clicar btnTop.addEventListener("click", () => { window.scrollTo({ top: 0, behavior: "smooth" }); }); .scielo__logo-partner{ max-height: 50px; max-width: 170px; } .scielo__logo-partner--dark{ display:none; } .scielo__theme--dark .scielo__logo-partner--light{ display:none; } .scielo__theme--dark .scielo__logo-partner--dark{ display:inline-block; } Brazil Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil E-mail: [email protected] Read our Open Access Statement Metrics SciELO Analytics Dimensions Altmetric Scite_ Vitamin D: the tricky hormone PlumX × Close Message × Close Message Report error // Variáveis para tradução da barra de acessibilidade window.accessibilityTranslations = { darkMode: "Dark mode", increaseText: "Increase text", decreaseText: "Decrease text", originalText: "Original text", markerLine: "Marker", readingLine: "Guide line", reset: "Reset", accessibilityMenu: "Accessibility menu", skipLinkText: "Ir para o conteúdo principal" }; $(document).ready(function() { // Add rows article search let addRowBtn = $('.addRowBtn'); let placeRow = $('.scielo__dinamic-row'); let newFormRow = ' clear AND OR AND NOT All indexes Year Author Funder Journal Abstract Title '; let btnRemoveRow = $('.btn-danger'); addRowBtn.on( "click", function() { placeRow.append( newFormRow ); }) // Remove as linhas inseridas dinamicamente e as que já estavam lá. placeRow.on( "click", ".btn-danger", function() { $(this).parent().parent().animate({'opacity':0},300).hide(1); }) }); <!-- var insertScript = function(url, callback, parentNode) { var scriptNode = document.createElement("script"); scriptNode.src = url; scriptNode.onload = callback; parentNode.appendChild(scriptNode) } var headNode = document.getElementsByTagName("head")[0]; setTimeout(MathJax.Callback([insertScript, "//badge.dimensions.ai/badge.js", console.log, headNode]), 1500); --> affiliations = {}; function add_scimago_image(selector, remove_br=true, add_br_after=true, find_div=false){ $(selector).each( function () { if (remove_br){ $(this).find("br").remove() } internal_items = find_div ? $(this).find('div').not(".clearfix") : $(this).not(".clearfix") internal_items.each(function () { self = $(this); affiliation_name = $('span:first', self).text(); if (affiliation_name){ scimago_link = ' '; self.append(scimago_link); } }); if (add_br_after){ $(this).after(" ") } }); } add_scimago_image('#ModalScimago .info div') add_scimago_image('.tutors', remove_br=false, add_br_after=false, find_div=true) $(".scimago_link").click(function(e){ e.preventDefault(); affiliation_name = $(this).data("affiliation"); if (affiliation_name){ if (affiliations[affiliation_name]) { window.open(affiliations[affiliation_name], '_blank'); } else { $.ajax({ type: "GET", async: false, url: "/scimago/query?ilang=en", data: 'q=' + encodeURI(affiliation_name), success: function (data) { if (data) { affiliations[affiliation_name] = 'https://www.scimagoir.com/' + data window.open(affiliations[affiliation_name], '_blank'); }else{ toastr.options = { positionClass: 'toast-top-center' }; toastr.error('Link temporariamente indisponível'); } } }); } } }); var howcite_initialized = false; var citeCslBase = "/citation/zYKPc7h95F8tB567PM5Mcrr/?ilang=en"; $('#ModalHowcite').on('shown.bs.modal', function () { if (!howcite_initialized) { initial = { "American Psychological Association": "apa", "Vancouver": "vancouver" } $.each(initial, function (key, value) { $.ajax({ url: citeCslBase + (citeCslBase.indexOf('?') >= 0 ? '&' : '?') + 'style=' + value, dataType: 'html', delay: 250, async: true }) .done(function (html) { $(" " + key + " " + " " + html + " ").insertBefore($("#select_label")); }) }); howcite_initialized = true; } $(".js-data-example-ajax").select2({ ajax: { url: "/citation/list?ilang=en", dataType: 'json', delay: 250, data: function (params) { return { q: params.term, // search term }; }, processResults: function (data, params) { return { results: data.results }; }, cache: true }, escapeMarkup: function (markup) { return markup; }, minimumInputLength: 1, dropdownParent: $('#ModalHowcite') }); $(document).on('select2:open', () => { document.querySelector('.select2-search__field').focus(); }); $(".js-data-example-ajax").on('select2:select', function (e) { var data = e.params.data; $.ajax({ url: citeCslBase + (citeCslBase.indexOf('?') >= 0 ? '&' : '?') + 'style=' + data.id, dataType: 'html', delay: 250 }) .done(function (html) { if ($('#citation_text').css('display') == 'none') { $('#citation_text').show() } $("#citation_text").html(html); }) .fail(function () { alert("Erro ao tentar obter esse estilo de citação"); }) }); }); // Garante que o valor do campo share_url é a URL corrente. $('#share_url').val(window.location.href); //moment.locale('en'); //$("#date").text(moment().format("L HH:mm:ss ZZ"));